Gliosis in neonatal SUDI cases

Chiu, May; Elder, Dawn; Zuccollo, Jane

doi:10.1111/j.1651-2227.2011.02413.x

Cited by 3 publications

(4 citation statements)

References 17 publications

(20 reference statements)

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“…This in agreement with Poets et al who, based on their 31 cases and 93 “controls,” estimated an odds ratio of 6.4 for SUPC to occur in prone or “potentially asphyxiating position” when an identified cause could not be identified [12]. Moreover, SUDI occurring in the first month of life is associated with bed sharing [14]. …”

Section: Discussionsupporting

confidence: 85%

“…One article refers only to one case of a female newborn where SUPC occurred at 2 days of life, in a cohort of infants in whom an anomaly of the pulmonary artery was found [13]. The other excluded article retrospectively reviews autopsies of neonatal SUDI cases occurring before 28 days of life, to look for brain lesions, and reports only one case of death that occurred in the first week of life, when “the infant was still in the neonatal ward,” but with no other perinatal information described [14]. Tables 1 and 2 give an overview of the remaining 398 cases of SUPC reported in 26 different studies.…”

Section: Resultsmentioning

confidence: 99%

“…They suggest that impaired cardiorespiratory control due to hypoxic ischemic insults occurring several days before death could contribute to these SUPC cases. A white matter gliosis was also found in 10 out of 16 unexplained SUDI cases, occurring mostly between days 8 and 28 of life [14]. However, these authors hypothesized that these lesions suggest that these infants could have experienced a previous prenatal or early postnatal central nervous system insult, thus making them vulnerable for known SIDS risk factors such as bed sharing.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Sudden Unexpected Postnatal Collapse of Newborn Infants: A Review of Cases, Definitions, Risks, and Preventive Measures

Herlenius

Kuhn

2013

Transl. Stroke Res.

102

100

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This study aimed to review available published reports concerning sudden unexpected postnatal collapse (SUPC) of apparently healthy infants within the first days of postnatal life, establish a structured presentation and delineate recommendations for preventive measures. All published reports of SUPC cases were retrospectively analyzed, and three not previously published SUPC cases at Karolinska University Hospital were detailed to exemplify the varying presentations and outcomes of SUPC. We found 398 published cases of SUPC occurring during first postnatal week. Estimated incidence of the SUPC of a presumably healthy infant after birth differs widely, ranging from 2.6 cases to 133 cases/100,000. However, definition, inclusion, and exclusion criteria vary substantially between reports. Our summary indicates that reported SUPC occurs more frequently than expected from recent surveys. About half of the infants die, and of the remaining survivors, half have neurological sequela. Of the 233 cases of sudden unexpected death described, no etiology was found in 153 cases. When a defined time for the SUPC event is described, approximately one third of reported events occur during the first 2 h, between 2 and 24 h and between 1 and 7 days after birth, respectively. Adequate education of caregivers and appropriate surveillance during the first days of newborns should enable us to save hundreds of lives.

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Section: Discussionsupporting

confidence: 85%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Sudden Unexpected Postnatal Collapse of Newborn Infants: A Review of Cases, Definitions, Risks, and Preventive Measures

Herlenius

Kuhn

2013

Transl. Stroke Res.

102

100

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“…In this context these channels may be critical for water homeostasis and edema clearing (Zador et al, 2009; Saadoun and Papadopoulos, 2010). Gliosis is an important hallmark of SIDS (Kinney, 2009; Chiu et al, 2012). TNFa and various cytokines have also been linked to SIDS in several studies (Kadhim et al, 2003; Perskvist et al, 2008; Ferrante et al, 2010a,b; Vennemann et al, 2012); Disturbances in the pro-inflammatory cytokines could affect the homeostatic response of the respiratory network.…”

Section: Sids and Central Cardio-respiratory Controlmentioning

confidence: 99%

The physiological determinants of Sudden Infant Death Syndrome

Garcia¹,

Koschnitzky²,

Ramirez

2013

Respiratory Physiology & Neurobiology

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It is well-established that environmental and biological risk factors contribute to Sudden Infant Death Syndrome (SIDS). There is also growing consensus that SIDS requires the intersection of multiple risk factors that result in the failure of an infant to overcome cardio-respiratory challenges. Thus, the critical next steps in understanding SIDS are to unravel the physiological determinants that actually cause the sudden death, to synthesize how these determinants are affected by the known risk factors, and to develop novel ideas for SIDS prevention. In this review, we will examine current and emerging perspectives related to cardio-respiratory dysfunctions in SIDS. Specifically, we will review: (1) the role of the preBötzinger complex (preBötC) as a multi-functional network that is critically involved in the failure to adequately respond to hypoxic and hypercapnic challenges; (2) the potential involvement of the pre-BötC in the gender and age distributions that are characteristic for SIDS; (3) the link between SIDS and prematurity; and (4) the potential relationship between SIDS, auditory function, and central chemosensitivity. Each section underscores the importance of marrying the epidemiological and pathological data to experimental data in order to understand the physiological determinants of this syndrome. We hope that a better understanding will lead to novel ways to reduce the risk to succumb to SIDS.

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