Gliosarcoma: MR Features

Dwyer, K W; Naul, L. Gill; Hise, Joseph

doi:10.1097/00004728-199609000-00006

Cited by 23 publications

(13 citation statements)

References 8 publications

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“…GSC is a rare primary high‐grade primary brain neoplasm which characteristically abuts a dural surface and can demonstrate both extracranial extension and extracranial metastases . Both imaging findings and genetic findings overlap with GBM.…”

Section: Discussionmentioning

confidence: 99%

“…GSC is a rare primary high-grade primary brain neoplasm which characteristically abuts a dural surface and can demonstrate both extracranial extension and extracranial metastases. 10,[13][14][15] Both imaging findings and genetic findings overlap with GBM. While separate imaging and histologic case series have been performed, a large series correlating these findings has never been reported.…”

Section: Discussionmentioning

confidence: 99%

“…Typical imaging characteristics of GSC are that of a supratentorial intracranial lesion which most often abuts a dural surface, is peripherally located, and demonstrates irregular rim enhancement . Though multiple imaging‐based case series of varying sizes have been reported, correlative IDH immunostaining has not been incorporated.…”

Section: Introductionmentioning

confidence: 99%

“…8 Typical imaging characteristics of GSC are that of a supratentorial intracranial lesion which most often abuts a dural surface, is peripherally located, and demonstrates irregular rim enhancement. 7,[9][10][11][12][13] Though multiple imaging-based case series of varying sizes have been reported, correlative IDH immunostaining has not been incorporated. We present the largest known radiologic case series with immunohistochemical and histologic correlation and delineate their imaging spectrum.…”

Section: Introductionmentioning

confidence: 99%

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Gliosarcoma: Neuroimaging and Immunohistochemical Findings

Peckham

Osborn

Palmer

et al. 2018

Journal of Neuroimaging

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BACKGROUND AND PURPOSE Gliosarcoma (GSC) is an intra‐axial lesion which often abuts a dural margin and is composed of glial and mesenchymal elements. This lesion is considered a variant of isocitrate dehydrogenase (IDH)‐wild type glioblastoma (GBM). The purpose of this study is to evaluate the imaging and molecular features of GSC in a large patient cohort. METHODS Pathology‐proved GSC cases were collected from our quaternary care center spanning the last 16 years and IDH status was documented. Older GSC cases without prior immunohistochemical testing underwent tissue block staining to obtain IDH status. When available, p53, phosphate and tensin (PTEN), MIB‐1, EGFR amplification, and MGMT methylation were recorded and imaging findings tabulated. Logistic regression analyses were performed to determine correlation of molecular markers and imaging characteristics. RESULTS A total of 25 cases were identified (21 de novo, 4 post‐treatment). All lesions contacted a dural, pial, or ependymal surface and were negative for an IDH R132H mutation, including postradiation GSC. In total, 16 of 16 cases showed nonamplification of EGFR/CEP7, 2 of 16 demonstrated MGMT methylation, and multiple lesions demonstrated p53 and PTEN mutations. Imaging features included areas of nodular thickening in necrotic lesions which appeared to abut the site of dural contact. There was no significant correlation of molecular markers with imaging characteristics. CONCLUSION GSC was IDH(–) in all cases, supporting the current understanding of this lesion being a wild‐type GBM variant. Additional molecular markers demonstrated no significant correlation with imaging findings in this cohort.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Gliosarcoma: Neuroimaging and Immunohistochemical Findings

Peckham

Osborn

Palmer

et al. 2018

Journal of Neuroimaging

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show abstract

“…Additional variation is recognized in the mesenchymal component. 101,102 Gliosarcoma should be included in the differential diagnosis of any tumor that appears to be intra-axial but abuts a dural surface and shows imaging characteristics similar to gray matter on T2-weighted images. Fibrosarcoma, with smooth and striated muscle sarcoma, as well as bone or cartilaginous sarcoma, may also be found.…”

Section: Neuro-imaging Of Brain Tumorsmentioning

confidence: 99%