Glioneuronal tumor with neuropil‐like islands: A new entity

Abstract

Glioneuronal tumor with neuropil-like islands (GTNI) is a distinctive and rare tumor characterized by both glial and neuronal differentiation. However, unlike other mixed glioneuronal tumors, which are characterized by a favorable prognosis, this neoplasm has been found to be potentially aggressive. We report here a case arising in a 60-year old male patient who presented with seizures, forgetfulness and right-sided hemiparesis, due to a left frontal lobe tumor. Unlike most cases described in the literature, the present tumor was unique in its radiological appearance, which was cystic. On microscopic evaluation, the glial component was chiefly gemistocytic punctuated by neuropil-like islands. Strong nuclear immunolabeling of p53 and absence of 1p/19q deletion by fluorescence in situ hybridization assay were consistent with those in previous reports.

Spinal cord glioneuronal tumor with neuropil-like islands with 1p/19q deletion in an adult with low-grade cerebral oligodendroglioma

“…Since this tumor's initial description [3], approximately 25 cases of GTNI have been published (Table 1). With the exception of two spinal cord lesions, one in a 44-year-old woman [4] and one in a 48-year-old man [5], all tumors in adult patients have been intracranial [2,3,[6][7][8][9][10][11][12]. In contrast, all reported pediatric GTNIs have originated in the spinal cord [13][14][15].…”

Disseminated Glioneuronal Tumor with Neuropil-Like Islands of the Spinal Cord: A Distinctive Entity

“…Most of the patients reported in the literature have been treated by partial resection of the tumor due to its diffusely permeative growth pattern. Therefore, they are likely to recur locally and exhibit an unfavorable clinical prognosis, particularly in spinal locations, after a few years of the diagnosis (1,11). Our patient underwent a gross total resection of the spinal tumor followed by a 12-month course of chemotherapy to delay radiotherapy until the age of 3 years.…”

Tumours of the Central Nervous System

“…The neuropil-like islands are decorated (rosetted) by small oligodendrocyte-like cells and atypical neurons (Agarwal et al, 2009). 6.6.9 Rosette-Forming Glioneuronal Tumour of the IV th Ventricle…”