Glioneuroma of Iris and Ciliary Body

Addison, David J.; Font, Ramon L.

doi:10.1001/archopht.1984.01040030337032

Cited by 16 publications

(4 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From a histological viewpoint, choroidal schwannoma should be differentiated from malignant melanoma [8], leiomyoma (mesectodermal leiomyoma) [8, 9]and glioneuroma [10]. The distinction from malignat melanoma is crucial, because an improper diagnosis would give rise to a serious problem for patient management.…”

Section: Discussionsupporting

confidence: 43%

“…Such findings are absent in the present case, in addition to the absence of other immunohistochemical markers for smooth muscle, α-smooth-muscle actin and desmin. Glioneuroma is a rare tumor which usually arises in the younger generation [10]. Histological examination reveals obvious neuronal and glial components, which are not evident in our case morphologically, immunohistochemically or ultrastructurally.…”

Section: Discussionsupporting

confidence: 41%

See 1 more Smart Citation

Choroidal Schwannoma: Immunohistochemical and Electron-Microscopic Study

Matsuo

Notohara

2000

Ophthalmologica

View full text Add to dashboard Cite

Schwannoma (neurilemoma) arising from the ciliary body and choroid is a rare form of intraocular tumor and usually misdiagnosed clinically as amelanotic melanoma. This case report describes a 73-year-old woman who developed a large nonpigmented intraocular tumor of the choroid in the left eye and underwent enucleation with a clinical diagnosis of malignant melanoma. The tumor consisted of spindle-shaped cells with an indefinite cytoplasm and twisted nuclei, which had positive immunoreactivity for S-100 protein, vimentin, glial fibrillary acidic protein and neural cell adhesion molecule. A continuous basal lamina encompassing the tumor cells was demonstrated by immunostaining for laminin and type IV collagen. Ultrastructurally, tumor cells with scant organelles had delicate cytoplasmic processes apposing each other, all indicative of Schwann cell origin. In reexamination of fluorescein angiograms, ultrasonograms and magnetic resonance images, no findings were incompatible with a diagnosis of choroidal melanoma. Histopathological studies showed that the tumor was a schwannoma. At present, we do not have a benchmark for the clinical diagnosis of intraocular schwannoma.

show abstract

Section: Discussionsupporting

confidence: 43%

Section: Discussionsupporting

confidence: 41%

Choroidal Schwannoma: Immunohistochemical and Electron-Microscopic Study

Matsuo

Notohara

2000

Ophthalmologica

View full text Add to dashboard Cite

show abstract

“…3 Glioneuromas composed of admixed glial and neuronal cells have also been reported in patients without a diagnosis of NF1. 4,5 To our knowledge, this is the first report of a retinal glioneuronal hamartoma in NF1. While ocular findings such as iris Lisch nodules, ciliary body and diffuse choroidal neurofibromas, optic nerve gliomas, sphenoid bone dysplasia, and eyelid plexiform neuromas have frequently been noted in patients with NF1, [6][7][8] retinal tumors have rarely been described.…”

mentioning

confidence: 75%

Retinal Glioneuronal Hamartoma in Neurofibromatosis Type 1

Lad¹,

Karamchandani²,

Alcorn³

et al. 2012

Arch Ophthalmol

View full text Add to dashboard Cite

“…This rare congenital embryonic tumor is reported in pediatric or young human patients. 1,14,19,31 Medulloepithelioma is a very rare tumor in dogs 2,8,15,26 and horses, 18 and is extremely rare in cats. 12 Isolated cases have been reported in other species, including birds 5 and llamas.…”

mentioning

confidence: 99%

Ocular glioneuroma with medulloepitheliomatous differentiation in a goldfish (Carassius auratus)

et al. 2014

View full text Add to dashboard Cite

Brief communicationSpontaneous ocular tumors arising from the retina are rare in fish. Reported lesions include adenocarcinoma of the retinal pigment epithelium in a guppy (Poecilia reticulata) and retinoblastoma in a spring cavefish (Forbesichthys agassizii; syn. Chologaster agassizi), porkfish (Anisotremus virginicus), and brown bullhead (Ameiurus nebulosus; syn. Ictalurus nebulosus).9,10,27 Two medulloepithelioma have been described in a goldfish (Carassius auratus) 17 and in a tinfoil barb (Barbonymus schwanenfeldii; syn. Barbodes subwanefeldi).13 Among other primitive ocular neoplasms with an ectodermic origin, a primitive neuroectodermal tumor was reported in a telescope goldfish. 3In veterinary medicine, there are no reports of glioneuroma to the authors' knowledge. This rare congenital embryonic tumor is reported in pediatric or young human patients. 1,14,19,31 Medulloepithelioma is a very rare tumor in dogs 2,8,15,26 and horses, 18 and is extremely rare in cats. 12 Isolated cases have been reported in other species, including birds 5 and llamas. 30 The present study describes the histomorphological and immunohistochemical features of a spontaneous intraocular tumor suggestive of a glioneuroma with medulloepitheliomatous differentiation in an adult goldfish (Carassius auratus).Glioneuroma and medulloepithelioma may arise from either the outer or the inner layer of the optic cup and from primitive medulloepithelium. 24 It is generally thought that medulloepithelioma is a true neoplasm originating from developing embryonal retinal cells, while glioneuroma is regarded as a choristomatous malformation consisting of glial and neuronal cells without obvious neoplastic potential. 14 An adult female goldfish living in a 50-liter hobbyist aquarium was presented with unilateral progressive exophthalmos of the left eye. While the animal's body condition deteriorated and the left eye continually enlarged, the fish maintained an appropriate body position in the water column for the several months prior to death. Only a few days before death, the fish listed to the left and its head dragged along the bottom. The right eye was normal in size and had a red pigmentation of the limbus. Neither medical treatment of the eye nor disinfection of the aquarium was carried out. The fish shared the aquarium with another goldfish found dead with gross and microscopic lesions of mycobacteriosis. Abstract. An intraocular mass in the left eye causing chronic severe exophthalmia in an adult female goldfish (Carassius auratus) is described. The fish shared an aquarium with another goldfish found dead with gross and microscopic lesions consistent with mycobacteriosis. Histological examination of the left eye, histochemical (periodic acid-Schiff [PAS], Alcian blue, Ziehl-Neelsen) and immunohistochemical tests (glial fibrillary acidic protein, human neuronal protein, vimentin, and cytokeratin AE1/AE3) were carried out on the intraocular mass. Neoplastic cells forming an unencapsulated highly cellular proliferation partially covered by a...

show abstract

Glioneuroma of Iris and Ciliary Body

Cited by 16 publications

References 3 publications

Choroidal Schwannoma: Immunohistochemical and Electron-Microscopic Study

Choroidal Schwannoma: Immunohistochemical and Electron-Microscopic Study

Retinal Glioneuronal Hamartoma in Neurofibromatosis Type 1

Ocular glioneuroma with medulloepitheliomatous differentiation in a goldfish (Carassius auratus)

Contact Info

Product

Resources

About