Glioma of the Acoustic Nerve

Kasantikul, Vira; Palmer, James O.; Netsky, Martin G.; Glasscock, Michael E.; Hays, James W.

doi:10.1001/archotol.1980.00790320008003

Cited by 26 publications

(14 citation statements)

References 20 publications

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“…This is a rare phenomenon, with only eleven unique cases reported in the literature prior to 2014. 16–26 All eight cases demonstrated abnormal T2 FLAIR hyperintensity, constrast enhancement, and expansion of a cisternal cranial nerve and its root entry zone contiguous with a brainstem parenchymal lesion.…”

Section: Discussionmentioning

confidence: 98%

“…16–26 Only eight of the cases describe imaging findings as three of the cases predate modern imaging. In eight of the reported patients, patient age is available and reveals a mean age of 36 years with a range of 8 to 70 years.…”

Section: Discussionmentioning

confidence: 99%

“…16–26 Through our MR imaging glioma database we have identified eight additional cases of pathologically confirmed gliomas with imaging findings indicating direct involvement of the cranial nerves. One of our cases (Case 1) has since recently been separately reported in the neurosurgery literature.…”

Section: Introductionmentioning

confidence: 99%

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Direct Cranial Nerve Involvement by Gliomas: Case Series and Review of the Literature

Mabray¹,

Glastonbury²,

Mamlouk³

et al. 2015

American Journal of Neuroradiology

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Malignant gliomas are characterized by infiltrative growth of tumor cells, including along white matter tracts. This may result in clinical cranial neuropathy due to direct involvement of a cranial nerve rather than by leptomeningeal spread along cranial nerves. Gliomas directly involving cranial nerves III-XII are rare with only eleven cases reported in the literature prior to 2014, including eight with imaging. We present eight additional cases demonstrating direct infiltration of a cranial nerve by glioma. Asymmetric cisternal nerve expansion as compared to the contralateral nerve was noted with a mean length of involvement of 9.4 mm. Based on our case series, the key imaging feature to recognize direct cranial nerve involvement by a glioma is the detection of an intra-axial mass in the pons or midbrain that is directly associated with expansion, signal abnormality, and/or enhancement of the adjacent cranial nerve(s).

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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Direct Cranial Nerve Involvement by Gliomas: Case Series and Review of the Literature

Mabray¹,

Glastonbury²,

Mamlouk³

et al. 2015

American Journal of Neuroradiology

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“…Indeed, it may be situated well within the internal auditory meatus. This readily explains the occurrence of various gliomas at this location (13). As an aside, even the leptomeninges may be the primary site of various gliomas, including astrocytoma, oligodendroglioma, ependymoma, and glioblastoma multiforme (15).…”

Section: Figure 3 Immunostaining For Synaptophysin Is Positive (A) mentioning

confidence: 89%

Neurocytoma of the VIIIth Cranial Nerve: Case Report

et al. 2005

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“…To our knowledge, (Table 1). 1,2,6,9,13,17,20,25 Each tumor was completely separate from the brainstem. On the basis of the currently available data, our case appears to be the first report of a primary extraaxial CPA glioblastoma.…”

Section: Discussionmentioning

confidence: 99%

Primary glioblastoma of the cerebellopontine angle in adults

Liu²,

Zhu

et al. 2011

JNS

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Gliomas are rare entities in the cerebellopontine angle (CPA) in adults. The authors present clinical, neuroradiological, serological, and neuropathological findings in a 60-year-old man with an extraaxial CPA glioblastoma arising from the proximal portion of cranial nerve VIII. The patient presented with progressive left-sided deafness and left-sided facial palsy lasting less than 2 months and progressive dysarthria and dysphagia lasting 2 weeks. Preoperative neuroimaging suggested the diagnosis of CPA meningioma with "dural-tail" sign and involvement of the internal auditory canal. Serological examination showed an increase in the malignant markers of ferritin and neuron-specific enolase, which suggested underlying malignancy. The tumor was subtotally removed, and it was confirmed to be completely separated from the brainstem and cerebellum. Cranial nerves VII and VIII were destroyed and sacrificed. Transient severe bradycardia occurred during surgery due to entrapment of the caudal cranial nerve complex by the tumor in such an infiltrative way. The neuropathological examination revealed a glioblastoma. The patient underwent no further treatment and died of cachexia 2 months postoperatively. To the authors' knowledge, this represents the first case of a primary glioblastoma in the CPA in an adult. A high index of suspicion along with reliance on clinical assessment, radiological findings, and serum detection of specific malignant markers is essential to diagnose such uncommon CPA lesions.

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Glioma of the Acoustic Nerve

Cited by 26 publications

References 20 publications

Direct Cranial Nerve Involvement by Gliomas: Case Series and Review of the Literature

Direct Cranial Nerve Involvement by Gliomas: Case Series and Review of the Literature

Neurocytoma of the VIIIth Cranial Nerve: Case Report

Primary glioblastoma of the cerebellopontine angle in adults

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