Glioma-Induced Alterations in Excitatory Neurons are Reversed by mTOR Inhibition
Alexander R. Goldberg,
Athanassios Dovas,
Daniela Torres
et al.
Abstract:Gliomas are highly aggressive brain tumors characterized by poor prognosis and composed of diffusely infiltrating tumor cells that intermingle with non-neoplastic cells in the tumor microenvironment, including neurons. Neurons are increasingly appreciated as important reactive components of the glioma microenvironment, due to their role in causing hallmark glioma symptoms, such as cognitive deficits and seizures, as well as their potential ability to drive glioma progression. Separately, mTOR signaling has bee… Show more
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