Glioblastoma With Metastasis to the Spleen -Case Report-

Yasuhara, Takao; Tamiya, Takashi; Meguro, Toshinari; Ichikawa, Tomotsugu; Sato, Yumiko; Date, Isao; Nakashima, Hiroyuki; Ohmoto, Takashi

doi:10.2176/nmc.43.452

Cited by 32 publications

(22 citation statements)

References 15 publications

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“…Especially they spread to lymph nodes (51.4%), lungs and pleura (59.7%), bone (30.5%) and rarely to liver (22.2%). Other more rare extracranial metastatic places are spinal cord, skin, small bowel, parotid gland and other organ systems (6,12).…”

Section: öZmentioning

confidence: 99%

Multiple extracranial metastases from secondary glioblastoma: a case report and review of the literature

Taşkapılıoğlu¹,

Aktas²,

Ocak³

et al. 2012

Turkish Neurosurgery

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Glioblastoma represents extreme anaplasia in astrocytic tumors. In spite of this aggressiveness, extracranial metastasis of glioblastoma is very rare and has been documented in only a few patients in the literature. In this article, a 30-year-old woman with secondary glioblastoma associated with extracranial distant metastasis was presented. In September 2008, an intracranial lesion in the left frontal region was diagnosed by magnetic resonance imaging (MRI) after admission to the hospital by headache and seizure and subsequently resected. The histology of the lesion revealed an anaplastic astrocytoma (grade III). Upon recurrence of the tumor 7 months later, the patient underwent a second craniotomy for recurrence tumor resection. The histological diagnosis was glioblastoma. After radiotherapy and chemotherapy, cranial computerized tomography (CT) and whole body scintigraphy revealed metastatic lesions in the right cervical lymph nodes and the left ischium. A neck dissection and parathyroidectomy on the right side was performed. The cytomorphological and histological features of the tumor supported the diagnosis of metastatic glioblastoma. KeywOrds: Glioblastoma, Extracranial metastasis, Secondary glioblastoma, Prognosis ÖZGlioblastom astrositik tümörler içerisinde en fazla anaplaziyi gösterenidir. Bu agresif davranışı yanında ekstrakraniyal metastazları oldukça nadirdir ve literatürde çok az hastada bildirilmiştir. Bu makalede, 30 yaşında sekonder glioblastoma bağlı ekstrakraniyal uzak metastazları bulunan bir bayan hasta sunulmuştur. Eylül 2008 tarihinde baş ağrısı ve nöbet şikayeti ile hastaneye başvuran hastanın çekilen kraniyal manyetik rezonans görüntülemesinde sol frontal bölgede intrakraniyal kitle saptanmıştı. Hasta opere edildi. Patoloji tanısı anaplastik astrositom (grade III)olarak raporlandı. 7 ay sonra rekürrens nedeniyle hasta tekrar opere edildi. Histolojik tanısı glioblastom olarak raporlandı. Radyoterapi ve kemoterapiden sonra çektirilen bilgisayarlı tomografi ve tüm vücut sintigrafisinde sağ servikal lenf nodları ve sol iskiumda metastatik lezyonlar saptandı. Sağ taraflı boyun diseksiyonu ve paratiroidektomi uygulandı. Sitomorfolojik ve histolojik çalışmalar metastatik glioblastomla uyumlu olarak bildirildi.

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Section: öZmentioning

confidence: 99%

Multiple extracranial metastases from secondary glioblastoma: a case report and review of the literature

Taşkapılıoğlu¹,

Aktas²,

Ocak³

et al. 2012

Turkish Neurosurgery

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“…Despite advances in surgical, medical and radiation therapies, the mortality of GBM remains high, with a median survival ranging between 40 and 70 weeks (2). Like other primary brain tumors, the extracranial metastasis of GBM is extremely rare, occurring in <2% of all GBMs (3)(4)(5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Extracranial metastasis of gliobastoma: Three illustrative cases and current review of the molecular pathology and management strategies

Ray

Manjila

Hdeib

et al. 2015

Molecular and Clinical Oncology

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Abstract. Glioblastoma (GBM) is the most common and the most malignant primary brain tumor in adults, accounting for ~12-15% of all intracranial neoplasms. Despite advances in surgical, medical and radiation therapies, the mortality of GBM remains high, with a median survival ranging between 40 and 70 weeks. Similar to other primary brain tumors, the extracranial metastasis of GBM is extremely rare, occurring in <2% of patients. To demonstrate the clinical characteristics of this rare tumor, we herein present three cases of extracranial GBM metastasis: One to the lungs, which represents the longest reported survival of lung metastases from GBM to date; the second to the soft tissue of the posterior neck; and the third to the lumbar intradural space. Unlike tumors elsewhere, there are unique barriers in the brain that prevent the hematogenous and lymphatic spread of intracranial tumors, such as the dura mater and the thickened basement membrane of the blood vessels. In addition, central nervous system tumor cells lack extracellular matrix proteins required to invade surrounding connective tissue, a prerequisite for tumor dissemination. In this study, we aimed to investigate the different possible mechanisms underlying the extracranial metastasis of GBM and determine the biomolecular and genetic characteristics differentiating GBMs that metastasize from those that do not. We also reviewed the role of systemic chemotherapy and bevacizumab in the treatment of disseminated GBMs. Early identification and differentiation of these tumors may enable patients to benefit from surgical resection, radiation and combination chemotherapy prior to developing other comorbidities from metastatic disease, which may translate into prolonged survival with an acceptable quality of life.

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“…Risk factors for extracranial metastasis include previous craniotomy, ventricular systemic shunting, high-grade tumor histology, radiation therapy, long interval since the primary therapy and tumoral relapse 17). In our case, the patient received craniotomy and some residual tumor attached to the sigmoid sinus and the petrosal vein remained.…”

Section: Discussionmentioning

confidence: 73%

Primary Intracranial Malignant Melanoma with Extracranial Metastasis

Hirota

Yoshimura

Kubo

et al. 2017

J Korean Neurosurg Soc

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We report a case of primary intracranial malignant melanoma (PIMM) with extracranial metastases. The patient was an 82-year-old woman diagnosed with PIMM under the left cerebellar tentorium. We performed a tumor resection followed by gamma knife surgery. An magnetic resonance imaging at 11 months after surgery showed a local intracranial recurrence. At 12 months, vertebral metastasis was suspected, and 2-[fluorine-18]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (FDG-PET/CT) showed multiple extracranial metastases. She died at 13 months after surgery. Although extracranial metastases of PIMM are extremely rare, we should carefully follow up extracranial metastases together with intracranial ones, especially by FDG-PET/CT, even at an early asymptomatic stage.

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Glioblastoma With Metastasis to the Spleen -Case Report-

Cited by 32 publications

References 15 publications

Multiple extracranial metastases from secondary glioblastoma: a case report and review of the literature

Multiple extracranial metastases from secondary glioblastoma: a case report and review of the literature

Extracranial metastasis of gliobastoma: Three illustrative cases and current review of the molecular pathology and management strategies

Primary Intracranial Malignant Melanoma with Extracranial Metastasis

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