Glioblastoma with deep supratentorial extension is associated with a worse overall survival

Barsouk, Adam; Baldassari, Michael P.; Khanna, Omaditya; Andrews, Carrie E.; Ye, Donald Y.; Velagapudi, Lohit; Saiegh, Fadi Al; Hafazalla, Karim; Cunningham, Erica; Patel, Heli; Malkani, K; Fitchett, Evan; Farrell, Christopher; Judy, Kevin

doi:10.1016/j.jocn.2021.08.025

Cited by 4 publications

(2 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When the HGGs extend over the tentorium, they can involve the thalamus, the basal ganglia, and the corpus collosum, which are deep structures that are difficult to treat surgically, since any damage to them may cause heavy neurological repercussions [ 57 ]. HGG patients, therefore, often have a shorter survival than the others do, due to more limited tumor resection.…”

Section: Advances In Prognosismentioning

confidence: 99%

See 1 more Smart Citation

Recapitulating the Key Advances in the Diagnosis and Prognosis of High-Grade Gliomas: Second Half of 2021 Update

Fròsina

2023

IJMS

View full text Add to dashboard Cite

High-grade gliomas (World Health Organization grades III and IV) are the most frequent and fatal brain tumors, with median overall survivals of 24–72 and 14–16 months, respectively. We reviewed the progress in the diagnosis and prognosis of high-grade gliomas published in the second half of 2021. A literature search was performed in PubMed using the general terms “radio* and gliom*” and a time limit from 1 July 2021 to 31 December 2021. Important advances were provided in both imaging and non-imaging diagnoses of these hard-to-treat cancers. Our prognostic capacity also increased during the second half of 2021. This review article demonstrates slow, but steady improvements, both scientifically and technically, which express an increased chance that patients with high-grade gliomas may be correctly diagnosed without invasive procedures. The prognosis of those patients strictly depends on the final results of that complex diagnostic process, with widely varying survival rates.

show abstract

Section: Advances In Prognosismentioning

confidence: 99%

“…( j ). Involvement of a greater number of deep-seated brain structures is associated with progressively worsening OS by pooled log-rank analysis (reproduced from [ 57 ] with permission). ( k , l ).…”

Section: Figurementioning

confidence: 99%

Recapitulating the Key Advances in the Diagnosis and Prognosis of High-Grade Gliomas: Second Half of 2021 Update

Fròsina

2023

IJMS

View full text Add to dashboard Cite

show abstract

Midline invasion predicts poor prognosis in diffuse hemispheric glioma, H3 G34-mutant: an individual participant data review

Kegoya,

Otani,

Inoue

et al. 2024

J Neurooncol

View full text Add to dashboard Cite

Introduction Diffuse hemispheric glioma, H3 G34-mutant (DHGs), is a newly categorized tumor in pediatric-type diffuse high-grade gliomas, World Health Organization grade 4, with a poor prognosis. Although prognostic factors associated with genetic abnormalities have been reported, few reports have examined the clinical presentation of DHGs, especially from the viewpoint of imaging findings. In this study, we investigated the relationship between clinical factors, including imaging findings, and prognosis in patients with DHGs. Methods We searched Medline through the PubMed database using two search terms: “G34” and “glioma”, between 1 April 2012 and 1 July 2023. We retrieved articles that described imaging findings and overall survival (OS), and added one DHG case from our institution. We defined midline invasion (MI) as invasion to the contralateral cerebrum, brainstem, corpus callosum, thalamus, and basal ganglia on magnetic resonance imaging. The primary outcome was 12-month survival, estimated using Kaplan–Meier curves and logistic regression. Results A total of 96 patients were included in this study. The median age was 22 years, and the proportion of male patients was 48.4%. Lesions were most frequently located in the frontal lobe (52.6%). MI was positive in 39.6% of all patients. The median OS was 14.4 months. Univariate logistic regression analysis revealed that OS was significantly worse in the MI-positive group compared with the MI-negative group. Multivariate logistic regression analysis revealed that MI was an independent prognostic factor in DHGs. Conclusions In this study, MI-positive cases had a worse prognosis compared with MI-negative cases. Previous presentations No portion of this study has been presented or published previously.

show abstract

Surgical resection of glioblastoma in basal ganglia and utility of exoscope: Technical case reports

Kijima¹,

Kinoshita²,

Kagawa³

et al. 2023

Surgical Neurology International

View full text Add to dashboard Cite

Background: Due to the presence of many perforating arteries and the deep location of basal ganglia tumors, dissection of the perforating arteries is critical during tumor resection. However, this is challenging as these arteries are deeply embedded in the cerebrum. Surgeons need to bend their heads for a long time using operative microscope and it is uncomfortable for the operating surgeon. A high-definition (4K-HD) 3D exoscope system can significantly improve the surgeon’s posture during resection and widen the operating view field considerably by adjusting the camera angle. Methods: We report two cases of glioblastoma (GBM) involving basal ganglia. We used a 4K-HD 3D exoscope system for resecting the tumor and analyzed the intraoperative visualization of the operative fields. Results: We could approach the deeply located feeding arteries before successfully resecting the tumor using a 4K-HD 3D exoscope system which would have been difficult with the sole use of an operative microscope. The postoperative recoveries were uneventful in both cases. However, postoperative magnetic resonance imaging showed infarction around the caudate head and corona radiata in one of the cases. Conclusion: This study has highlighted using a 4K-HD 3D exoscope system in dissecting GBM involving basal ganglia. Although postoperative infarction is a risk, we could successfully visualize and dissect the tumors with minimal neurological deficits.

show abstract

Glioblastoma with deep supratentorial extension is associated with a worse overall survival

Cited by 4 publications

References 21 publications

Recapitulating the Key Advances in the Diagnosis and Prognosis of High-Grade Gliomas: Second Half of 2021 Update

Recapitulating the Key Advances in the Diagnosis and Prognosis of High-Grade Gliomas: Second Half of 2021 Update

Midline invasion predicts poor prognosis in diffuse hemispheric glioma, H3 G34-mutant: an individual participant data review

Surgical resection of glioblastoma in basal ganglia and utility of exoscope: Technical case reports

Contact Info

Product

Resources

About