Glioblastoma-targeted, local and sustained drug delivery system based on an unconventional lipid nanocapsule hydrogel

Sicot, Marion; Gazaille, Claire; Bozzato, Elia; Madadian-Bozorg, Neda; Mellinger, Adélie; Saulnier, Patrick; Eyer, Joël; Bertrand, Nicolas; Préat, Véronique; Bastiat, Guillaume

doi:10.1016/j.bioadv.2023.213549

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Beyond the Surface: Peptide Functionalization Strategies For...2

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2024

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Cited by 4 publications

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“…In vivo studies using a murine model of GBM resection demonstrated that functionalized gemcitabine-loaded LNC targeted nonresected GBM cells, significantly delaying or inhibiting the appearance of recurrences. The median survival with modified hydrogels was prolonged considerably compared to nonfunctionalized hydrogels (74 days vs 44 days, respectively) …”

Section: Beyond the Surface: Peptide Functionalization Strategies For...mentioning

confidence: 98%

“…The median survival with modified hydrogels was prolonged considerably compared to nonfunctionalized hydrogels (74 days vs 44 days, respectively). 254 Kang and colleagues designed an injectable thermoresponsive hydrogel nanocomposite that incorporated DOX-loaded micelles and water-dispersible ferrimagnetic iron oxide nanocubes (wFIONs). To ensure drug targeting to GBM cells while reducing harm to healthy tissues, the backbone of the hydrogel was conjugated with T7 peptide.…”

Section: −•mentioning

confidence: 99%

“…The median survival with modified hydrogels was prolonged considerably compared to nonfunctionalized hydrogels (74 days vs 44 days, respectively). 254 …”

Section: Beyond the Surface: Peptide Functionalization Strategies For...mentioning

confidence: 99%

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