Glioblastoma Presenting as Spontaneous Subarachnoid Hemorrhage: Technical Case Note of Combined Endovascular and Microsurgical Vision-Sparing Treatment

Tan, Darius; Daly, Christopher; Xenos, Chris; Lai, Leon T.; Chandra, Ronil V.

doi:10.1016/j.wneu.2019.05.090

Cited by 3 publications

(5 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The clinical features of SAH in patients with active cancer are noticeable 10 , and may be an initial feature of the malignancy, complication of active malignancy or delayed consequence of cancer and its management 11 . In the present study, most SAH in patients with active cancer had common clinical manifestations, such as headache, nausea and vomiting which correlated with the findings of the previous studies 6, 7, 12, 13 . Further, this study represented the largest clinical series of SAH in patients with cancer.…”

Section: Discussionsupporting

confidence: 92%

“…Generally, this study was a retrospective comparison with propensity score-matching to minimize the bias in patient selection, but unobserved confounders remained. On the other hand, further research is needed because previous studies have suggested that factors affecting the occurrence of SAH include histological characteristics of the tumor, tumorous position, cancerous aneurysm and direct invasion of meningeal blood vessels, selective serotonin reuptake inhibitor as well as estrogen replacement therapy 6,[23][24][25][26][27][28][29][30] .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Cancer related subarachnoid hemorrhage: a multicenter retrospective study using propensity score matching analysis

K¹

2022

Preprint

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Cancer related subarachnoid hemorrhage: a multicenter retrospective study using propensity score matching analysis

K¹

2022

Preprint

View full text Add to dashboard Cite

show abstract

“…In the present study, most SAH in patients with active cancer had common clinical manifestations, such as headache, nausea and vomiting which correlated with the findings of the previous studies (Navi et al, 2010;Shibahara et al, 2016;Matsuda et al, 2018;Tan et al, 2019). Further, this study represented the largest clinical series of SAH in patients with cancer.…”

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Cancer Related Subarachnoid Hemorrhage: A Multicenter Retrospective Study Using Propensity Score Matching Analysis

Chen

Zhang

et al. 2022

Front. Cell. Neurosci.

View full text Add to dashboard Cite

ObjectiveTo investigate the clinical features, risk factors and underlying pathogenesis of cancer related subarachnoid hemorrhage (SAH).MethodsClinical data of SAH in patients with active cancer from January 2010 to December 2020 at four centers were retrospectively reviewed. Patients with active cancer without SAH were matched to SAH patients with active cancer group. Logistic regression was applied to investigate the independent risk factors of SAH in patients with active cancer, after a 1:1 propensity score matching (PSM). A receiver operator characteristic curve was configured to calculate the optimal cut-off value of the joint predictive factor for cancer related SAH.ResultsA total of 82 SAH patients with active cancer and 309 patients with active cancer alone were included. Most SAH patients with cancer had poor outcomes, with 30-day mortality of 41.5%, and with 90-day mortality of 52.0%. The PSM yielded 75 pairs of study participants. Logistic regression revealed that a decrease in platelet and prolonged prothrombin time were the independent risk factors of cancer related SAH. In addition, receiver operator characteristic curve of the joint predictive factor showed the largest AUC of 0.8131, with cut-off value equaling to 11.719, with a sensitivity of 65.3% and specificity of 89.3%.ConclusionPatients with cancer related SAH often have poor outcomes. The decrease in platelet and prolonged prothrombin time are the independent risk factors of cancer related SAH, and the joint predictive factor with cutoff value equal to 11.719 should hence serve as a novel biomarker of cancer related SAH.

show abstract

“…[6][7][8][9][10] Multiple reports exist of concurrent cerebral aneurysm and GBM, presumably from tumor involvement and weakening of en passage or feeding vessels. 11 In addition, previous cranial irradiation, certain chemotherapies, and even surgery are known risk factors for cerebral aneurysm formation, with multiple reports of such. 6,7,10,[12][13][14] It is not uncommon for these pseudoaneurysms to present in a delayed fashion, likely because of the total short observation time afforded most patients with glioblastoma; however, case reports of delayed cerebral pseudoaneurysm formation as a result of glioblastoma treatment are particularly rare.…”

Section: Discussionmentioning

confidence: 99%

Delayed cerebral pseudoaneurysm following surgical and combined-modality therapy for glioblastoma multiforme: illustrative case

Krishnakumar

Son

2022

Journal of Neurosurgery: Case Lessons

View full text Add to dashboard Cite

BACKGROUND Post–radiation therapy and chemotherapy cerebral pseudoaneurysms are rare entities. Within previous tumor treatment areas on nonvascular imaging, they are potentially confused as recurrent tumor. OBSERVATIONS A 61-year-old man was a long-term survivor of glioblastoma multiforme whose treatment consisted of open biopsy followed by radiotherapy to 60 Gy and systemic carmustine. On surveillance imaging, enlargement of a posttreatment cyst and new enhancing lateral “mural nodule” was first noticed approximately 16 years after initial treatment. Over 12 months, both continued to enlarge. Initially referred to as recurrence, subsequent angiography showed the mural nodule to be an unruptured distal middle cerebral artery pseudoaneurysm within the previous tumor bed. The patient underwent repeat craniotomy for clipping of the aneurysm and biopsy of the cyst wall, which was negative for malignancy. LESSONS Delayed pseudoaneurysms following radiation therapy and chemotherapy for malignant brain tumors are rare but have been previously reported. Their appearance on cross-sectional imaging can mimic recurrence, and they should be kept in the differential of new, circumscribed enhancement within such treatment areas.

show abstract

Glioblastoma Presenting as Spontaneous Subarachnoid Hemorrhage: Technical Case Note of Combined Endovascular and Microsurgical Vision-Sparing Treatment

Cited by 3 publications

References 15 publications

Cancer related subarachnoid hemorrhage: a multicenter retrospective study using propensity score matching analysis

Cancer related subarachnoid hemorrhage: a multicenter retrospective study using propensity score matching analysis

Cancer Related Subarachnoid Hemorrhage: A Multicenter Retrospective Study Using Propensity Score Matching Analysis

Delayed cerebral pseudoaneurysm following surgical and combined-modality therapy for glioblastoma multiforme: illustrative case

Contact Info

Product

Resources

About