Glioblastoma of the cerebellum and brainstem

Stark, Andreas M.; Maslehaty, Homajoun; Hugo, Heinz-Hermann; Mahvash, Mehran; Mehdorn, H. Maximilian

doi:10.1016/j.jocn.2010.02.015

Cited by 48 publications

(44 citation statements)

References 13 publications

(11 reference statements)

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“…However, infratentorial GBM is rare, and it accounts for 0.5%-l% of all intracranial GBM [1,2], only a few individual cases are reported [1,[3][4][5][6][7][8][9][10][11][12][13][14][15][16][17]. The largest-scale reports to date are a multicenter clinical retrospective study (including 45 patients) and a single-center (including 21 patients) clinical retrospective study [3,12].…”

Section: Introductionmentioning

confidence: 99%

Cerebellar glioblastoma multiforme: a retrospective study of 28 patients at a single institution

Yang

Liu

Wang

et al. 2013

International Journal of Neuroscience

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Cerebellar glioblastoma multiforme (CGBM) is rare and its treatment is ill defined. To elucidate prognostic factors, we performed a single institutional review of the largest series to date of CGBM. The West China Hospital database was reviewed from 2007 to June 2011, and a total of 28 CGBM patients were collected. Median age of patients was 50 years old, whereas median Karnofsky Performance Status was 80 (range, 30-100). Brainstem invasion was observed in 9 patients. Sixteen patients received total resection and 12 patients received subtotal resection. Postoperative Gamma Knife radiosurgery (GKRS) was administered to 22 patients. After operation, 16 patients received concurrent GKRS and chemotherapy, and 6 patients received chemotherapy after GKRS. In addition, 4 patients only received chemotherapy, and 2 patients did not receive either GKRS or chemotherapy due to various reasons. Median follow-up period was 13.7 months (range, 5.2-28.1 months). Median overall survival (OS) of 28 patients was 14.3 months and median progression-free survival (PFS) was 9.4 months. Univariate log-rank analysis showed that OS and PFS were significantly related to brainstem invasion (p = 0.03, p = 0.04, respectively), extent of resection (p = 0.02, p = 0.04, respectively) and GKRS (p = 0.01, p = 0.02, respectively) of GBM. Multivariate analysis revealed that OS and PFS were also significantly associated with brainstem invasion (p = 0.007, p = 0.014, respectively), extent of resection (p = 0.032, p = 0.045, respectively) and GKRS (p = 0.031, p = 0.046, respectively) of CGBM. According to our study, brainstem invasion, extent of resection and GKRS were major prognostic factors for survival. Combination of postoperative GKRS and chemotherapy had an improved prognosis, and it may be a feasible postoperative adjuvant treatment of CGBM.

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Section: Introductionmentioning

confidence: 99%

Cerebellar glioblastoma multiforme: a retrospective study of 28 patients at a single institution

Yang

Liu

Wang

et al. 2013

International Journal of Neuroscience

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“…These primarily include tetraplegia, paraplegia, sensory dysfunction, and gait ataxia , Shahideh et al 2012. While the vast majority of GBM tumors are found in the frontal, temporal, and parietal lobes of the cerebral cortex, they also occur in the cerebellum and brainstem in a small proportion of patients (Stark et al 2010). Patients with primary cerebellar GBM typically present signs such as headache, vomiting, and ataxia, whereas patients with GBM located at the brainstem present signs such as hemiparesis, vertigo, facial palsy, and difficulty in swallowing , Stark et al 2010.…”

Section: Symptoms Diagnosis and Managementmentioning

confidence: 99%

Drug delivery approaches for the treatment of glioblastoma multiforme

Fakhoury

2015

Artificial Cells, Nanomedicine, and Biotechnology

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“…Although glioblastoma is the most common primary brain tumor in adults, primary glioblastoma in the cerebellum is rare. 66,67 Rarely, an unruptured AVM or aneurysm can present as AVS by compression or displacement of adjacent tissue. 63 Abscesses can also present as mass lesions, and these are described in the next section.…”

Section: Posterior Fossa Neoplasms and Other Mass Lesionsmentioning

confidence: 99%