Glioblastoma multiforme y neoplasia endocrina múltiple tipo 2 A

Sánchez-Ortiga, Ruth; Carreño, Evangelina Boix; Moreno-Pérez, Óscar; Alfonso, Antonio Picó

doi:10.1016/j.medcli.2008.06.021

Cited by 7 publications

(2 citation statements)

References 12 publications

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“…Glioblastoma multiforme may also occur in the course of genetic diseases: tuberous sclerosis [ 15 ], Turcot syndrome [ 16 ], multiple endocrine neoplasia type IIA [ 17 ] and neurofibromatosis type I, NF1 [ 18 ]. In addition, acquired head injuries, which occurred as a result of a brain contusion, may predispose to the onset of glioblastoma [ 19 , 20 ].…”

Section: Etiologymentioning

confidence: 99%

Review Glioblastoma multiforme – an overview

Urbańska¹,

Sokołowska²,

Szmidt³

et al. 2014

225

217

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Glioblastoma multiforme is a central nervous system tumor of grade IV histological malignancy according to the WHO classification. Over 90% of diagnosed glioblastomas multiforme cases are primary gliomas, arising from normal glial cells through multistep oncogenesis. The remaining 10% are secondary gliomas originating from tumors of lower grade. These tumors expand distinctly more slowly. Although genetic alterations and deregulations of molecular pathways leading to both primary and secondary glioblastomas formation differ, morphologically they do not reveal any significant differences. Glioblastoma is a neoplasm that occurs spontaneously, although familial gliomas have also been noted. Caucasians, especially those living in industrial areas, have a higher incidence of glioblastoma. Cases of glioblastoma in infants and children are also reported. The participation of sex hormones and viruses in its oncogenesis was also suggested. Progression of glioblastoma multiforme is associated with deregulation of checkpoint G1/S of a cell cycle and occurrence of multiple genetic abnormalities of tumor cells. Metastases of glioblastoma multiforme are rarely described. Treatment of glioblastoma multiforme includes tumor resection, as well as radiotherapy and chemotherapy. Drugs inhibiting integrin signaling pathways and immunotherapy are also employed. Treatment modalities and prognosis depend on the tumor localization, degree of its malignancy, genetic profile, proliferation activity, patient's age and the Karnofsky performance scale score. Although the biology of glioblastoma multiforme has recently been widely investigated, the studies summarizing the knowledge of its development and treatment are still not sufficient in terms of comprehensive brain tumor analysis.

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Section: Etiologymentioning

confidence: 99%

Review Glioblastoma multiforme – an overview

Urbańska¹,

Sokołowska²,

Szmidt³

et al. 2014

225

217

View full text Add to dashboard Cite

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“…The median survival rate after the final diagnosis has been estimated to be 12 to 15 months, despite a variety of therapies available ( 1 , 2 ). Additionally, many genetic disorders have been associated with the development of GB, such as Neurofibromatosis type I, Li Fraumeni syndrome and Multiple Endocrine Neoplasia type IIA ( 3 , 4 ). Global incidence of glioblastoma is less than 10/100,000, i.e.…”

Section: Introductionmentioning

confidence: 99%

Impact of Neurotropic Viruses on Survival of Patients with Surgically Treated Glioblastoma

Koruga

2022

ACC

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Glioblastoma represents the most aggressive tumor of the brain with an estimated survival rate of twelve to fifteen months after the primary diagnosis. The role of neurotropic viruses in pathogenesis of the tumor has remained unclear to date. During the last two decades, many studies were conducted with the aim of confirming viral influence in the development of glioblastoma.Methods: We conducted a retrospective study in a time period of five years using formalin-fixed paraffin-embedded tissues of glioblastoma. Immunohistochemistry was performed for three viruses: CMV, EBV and HSV-1, using an automated staining system.Results: Mean age of patients in our group was 66.7±8.5 years. A slight male dominance was noted. Negative immunohistochemistry results were obtained for CMV and EBV, which were excluded from further investigation. Based on IRS score, we confirmed six HSV-1 samples which were rated as IRS score 2. Five more samples of HSV-1 were rated as IRS score 1 and were excluded from the study.Conclusion: According to our retrospective study and its results, we found no impact of neurotropic viruses in the survival rate of glioblastoma. Further studies should be conducted including a wider range of viral detection methods.

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