Glioblastoma multiforme—report of 267 cases treated at a single institution

Stark, Andreas M.; Nabavi, Arya; Mehdorn, H. Maximilian; Blömer, Ulrike

doi:10.1016/j.surneu.2004.01.028

Cited by 224 publications

(156 citation statements)

References 24 publications

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“…The median OS was 11.8 months among 267 GBM patients (median age 61 years, median preoperative KPS 70%) treated at a single institute, but TMZ was used only in 20 patients. 17) The median OS was 12.2 months among 500 GBM patients (median age 60 years, median preoperative KPS 80%) in another institute. 16) The following variables were found to be significant prognostic factors favoring longer survival by multivariate analysis in the subtotal and partial groups: younger age, TMZ therapy, 60 Gy irradiation, MGMT-negative, and more than subtotal resection (Table 2).…”

Section: Discussionmentioning

confidence: 94%

Effectiveness of Maximal Safe Resection for Glioblastoma Including Elderly and Low Karnofsky Performance Status Patients: Retrospective Review at a Single Institute

Uzuka

Aoki

Natsumeda

et al. 2012

Neurol. Med. Chir.(Tokyo)

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Elderly and low Karnofsky performance status (KPS) patients have been excluded from most prospective trials. This retrospective study investigated glioblastoma treatment outcomes, including those of elderly and low KPS patients, and analyzed the prognostic factors using the medical records of 107 consecutive patients, 59 men and 48 women aged from 21 to 85 years (median 65 years), with newly diagnosed glioblastoma treated at our institute. There were 71 high-risk patients with age À70 years and/or KPS º70%. Based on the extent of resection, the patients were classified into 3 groups: more than subtotal resection (subtotal, n ＝ 44), partial resection (partial, n ＝ 29), and biopsy only (biopsy, n ＝ 34). Median overall survival (OS) of all 107 patients was 13.5 months. Median OS was 13.2 months in the high-risk group. Median OSs were 15.8, 12.8, and 12.1 months in the subtotal, partial, and biopsy groups, respectively. Multivariate analysis of 73 patients in the subtotal and partial groups found age Ã65 years (p ＝ 0.047), 60 Gy irradiation (p ＝ 0.009), O 6 -methylguanine-deoxyribonucleic acid methyltransferase-negative (p ＝ 0.027), and more than subtotal removal (p ＝ 0.003) were significant prognostic factors. The median postoperative KPS score tended to be better than the preoperative score, even in the high-risk group. We recommend maximal safe resection for glioblastoma patients, even those with advanced age and/or with low KPS scores.

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Section: Discussionmentioning

confidence: 94%

Effectiveness of Maximal Safe Resection for Glioblastoma Including Elderly and Low Karnofsky Performance Status Patients: Retrospective Review at a Single Institute

Uzuka

Aoki

Natsumeda

et al. 2012

Neurol. Med. Chir.(Tokyo)

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“…It is found most commonly as a primary tumor, with secondary tumor characteristics as result of transformation from low-grade glioma. [1][2][3][4][5][6][7][8] Intraventricular tumors represent only 10% of central nervous system neoplasms. Of those, the reported malignancy rate is 13% of all cases.…”

Section: Introductionmentioning

confidence: 99%

Third Ventricular Glioblastoma Multiforme: Case Report and Literature Review

Hariri¹,

Farr²,

Corsino³

et al. 2014

J Neurol Surg B

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BackgroundGBM is an intra-axial mass, localized to the frontotemporal region that accounts for 50 to 60% of astrocytomas and 12 to 15% of intracranial tumors. It is found most commonly as a primary tumor, with secondary tumor characteristics as result of transformation from low-grade glioma. 1-8 Intraventricular tumors represent only 10% of central nervous system neoplasms. Of those, the reported malignancy rate is 13% of all cases. Lee and Manzano enumerated the most frequently found ventricular system tumors, presented in ►Table 1. 9 The rarest lesions of the intraventricular region are GBM, ependymomas, gangliocytomas, and gliosarcomas. 10 Ependymomas occur at a frequency of 0.25% 11 and gangliocytomas with a frequency of 0.1 to 0.5%. 12 When AbstractBackground Glioblastoma multiforme (GBM) typically presents in the supratentorial white matter, commonly within the centrum semiovale as a ring-enhancing lesion with areas of necrosis. An atypical presentation of this lesion, both anatomically as well as radiographically, is significant and must be part of the differential for a neoplasm in this anatomical location. Case Description We present a case of a 62-year-old woman with headaches, increasing somnolence, and cognitive decline for several weeks. Magnetic resonance imaging demonstrated mild left ventricular dilatation with a well-marginated, homogeneous, and nonhemorrhagic lesion located at the ceiling of the third ventricle within the junction of the septum pellucidum and fornix, without exhibiting the typical radiographic features of hemorrhage or necrosis. Final pathology reports confirmed the diagnosis of GBM. Conclusion This case report describes an unusual location for the most common primary brain neoplasm. Moreover, this case identifies the origin of a GBM related to the paracentral ventricular structures infiltrating the body of the fornix and leaves of the septum pellucidum. To our knowledge this report is the first reported case of a GBM found in this anatomical location with an entirely atypical radiographic presentation.

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“…Please note that not all headaches indicate that someone will have a GBM. In fact, most headaches are not indicative of GBM and are likely related to myofascial inflammation of the neck muscles and/ or migraines [5][6][7][8].…”

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confidence: 99%

The human battle with glioblastoma multiforme: A true challenge

Ordookhanian¹

2017

Res Rev Insights

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Glioblastoma multiforme—report of 267 cases treated at a single institution

Cited by 224 publications

References 24 publications

Effectiveness of Maximal Safe Resection for Glioblastoma Including Elderly and Low Karnofsky Performance Status Patients: Retrospective Review at a Single Institute

Effectiveness of Maximal Safe Resection for Glioblastoma Including Elderly and Low Karnofsky Performance Status Patients: Retrospective Review at a Single Institute

Third Ventricular Glioblastoma Multiforme: Case Report and Literature Review

The human battle with glioblastoma multiforme: A true challenge

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