Glioblastoma multiforme of the medulla oblangata

Queiróz, Luciano de Souza; Neto, Joaquim N. da Cruz; Faria, J. Lopes de

doi:10.1007/bf00685488

Cited by 7 publications

(16 citation statements)

References 11 publications

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“…Although in the early report by Queiroz Lde et al ., there is mention of few other cases of GBM of medulla oblongata, but none of those cases are histologically documented. [6]…”

Section: Discussionmentioning

confidence: 99%

“…[910] Queiroz L de et al . [6] and Abbott et al . [3] has not commented on the histological type of GBM; however, the pathological findings described by Kyoshima et al .…”

Section: Discussionmentioning

confidence: 99%

“…[36] In their series, Abbott et al . reported six pediatric patients with intrinsic gliomas’ of the medulla oblongata, who underwent radical excision, one of them had a GBM, and died from tumor progression three months postoperatively.…”

Section: Discussionmentioning

confidence: 99%

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Primary glioblastoma multiforme of medulla oblongata: Case report and review of literature

et al. 2012

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Glioblastoma multiforme (GBM) is the most common glial tumor of the adult brain. However, the primary GBM of medulla oblongata is a rarity. To the best of our knowledge, only four cases of GBM of medulla oblongata have been reported so far in the literature, and this is the second report of conventional GBM of the medulla oblongata in adults. We describe a case of 51-year-old female, who presented with a heterogeneous mass with exophytic feature located in the caudal brain stem that was approached and a near total tumor removal was achieved by median suboccipital route. A literature review with emphasis on anatomical location, radiological and histopathological findings, extent of tumor resectibility, and outcome is included.

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“…Although in the early report by Queiroz Lde et al ., there is mention of few other cases of GBM of medulla oblongata, but none of those cases are histologically documented. [6]…”

Section: Discussionmentioning

confidence: 99%

“…[910] Queiroz L de et al . [6] and Abbott et al . [3] has not commented on the histological type of GBM; however, the pathological findings described by Kyoshima et al .…”

Section: Discussionmentioning

confidence: 99%

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Primary glioblastoma multiforme of medulla oblongata: Case report and review of literature

et al. 2012

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“…Primary gms of the pons and medulla are seldom encountered (Queiroz et al 1974), but secondary glioblastomatous change is a frequent occurrence in the brain-stem gliomas in children (Rubinstein 1972, Miiller 1973. The cerebellum and spinal cord are rare sites; one example of each location was observed in a personal series of about 800 glioblastomas confirmed by biopsy or autopsy, or by both.…”

Section: Sites: Multiplicitymentioning

confidence: 96%

Glioblastoma multiforme: Morphology and biology

Jellinger

1978

Acta neurochir

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Glioblastoma multiforme, representing about 50% of all gliomas, encompasses a group of intrinsic tumours of the brain in later years (age peak around 50 years), the morphological hallmarks of which are an ensemble of variations in tumour cell and tissue structure featuring its biological malignancy. Glioblastoma, while sometimes appearing as a distinct "primary" tumour type, is usually accepted as an extreme manifestation of anaplasia and dedifferentiation of glia, mostly astrocytic. The astrocytic nature of most glioblastomas has been confirmed by ultrastructural studies and progressive differentiation of tumours maintained in organotypic tissue culture. Reproducible experimental models are particularly induced by oncogenic RNA (oncorna) viruses. The cell kinetic parameters are similar to those of other solid malignant tumours except for a comparatively low growth fraction of glioblastoma. The frequent occurrence of giant cells as well as of regressive changes with necrosis and vascular responses are indirect (secondary) indicators of malignancy which coincide with histochemical (enzymatic anisochronia) and biochemical data (lower level of glia specific S100 protein than in differentiated gliomas). Vascular proliferation, a characteristic feature of glioblastoma, may occasionally progress to sarcomatous transformation with development of gliosarcomas (mixed glial-mesenchymal tumours). While dissemination of glioblastoma through the cerebrospinal pathways is not uncommon, extraneural distant metastatic spread is rare, and usually observed after craniotomy. The results of modern neuro-oncology support the pathogenetic view that glioblastoma results from neoplastic transformation of glial elements with continuing dedifferentiation. This transformation can be experimentally induced by various factors including oncogenic DNA (oncorna) viruses by using a reverse transcriptase, while there is indirect evidence for an oncorna-virus information in human glioblastoma. The significance of immunological factors in the pathogenesis of brain tumours and in the course of neoplastic transformation of glia is not yet understood, but both morphological and immunological data are in favour of a cell mediated immunological reaction against tumour-specific antibodies. Since immunological factors and changes in cytokinetics are apparently active after the transformed tumour cells proliferate, all available therapeutic methods, including radiation, chemotherapy, and immunotherapy of glioblastoma only influence the final stages of neoplastic development with clinical manifestation of the tumour. In spite of modern combination and multimodality therapy schemes the prognosis of glioblastoma is still poor.

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“…[4] To the best of our knowledge, only six cases of glioblastoma affecting the medulla have been described in the literature till now. [45678]…”

Section: Introductionmentioning

confidence: 99%

Dorsally exophytic glioblastoma arising from the medulla oblongata in an adult presenting as 4th ventricular mass

et al. 2017

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Brainstem gliomas are relatively rare in adults (<2% of all gliomas). Exophytic gliomas are focal brainstem lesions, which project into the 4th ventricle or cerebellopontine angles. These exophytic lesions are usually of low-grade histology (pilocytic astrocytoma or ganglioglioma) and have a relatively better outcome compared with brainstem gliomas as a whole. Glioblastoma is the commonest primary glial cell neoplasm and mostly occurs in the supratentorial compartment. It is rather uncommon in the brainstem and seldom has been described as having an exophytic growth pattern. Here we describe an exophytic brainstem glioblastoma arising from the medulla oblongata in a 55-year-old lady who presented with a 4th ventricular mass, and present a brief review of the literature. Till now, six cases of glioblastoma arising from the medulla oblongata have been reported. So, ours is the seventh such report. To the best of our knowledge, it also happens to be the sixth reported case of dorsally exophytic brainstem glioblastoma till date.

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Glioblastoma multiforme of the medulla oblangata

Cited by 7 publications

References 11 publications

Primary glioblastoma multiforme of medulla oblongata: Case report and review of literature

Primary glioblastoma multiforme of medulla oblongata: Case report and review of literature

Glioblastoma multiforme: Morphology and biology

Dorsally exophytic glioblastoma arising from the medulla oblongata in an adult presenting as 4th ventricular mass

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