Glioblastoma Multiforme in the Left Frontal Lobe Subsequent to Malignant Lymphoma in the Right Orbit —Case Report—

Abstract

A 62-year-old male presented with glioblastoma multiforme in the left frontal lobe manifesting as motor aphasia, subsequent to a malignant lymphoma in the right orbit. He underwent subtotal removal of the right orbital mass presenting as right exophthalmos which was shown by histological examination to be non-Hodgkin's lymphoma. He received 30 Gy Lineac irradiation to the right orbit. His post-operative course was satisfactory. Magnetic resonance (MR) imaging with gadolinium-diethylenetriaminepenta-acetic acid (Gd-DTPA) 7 months later demonstrated a small spotty enhanced lesion in the left frontal lobe. He developed motor aphasia 1 year after irradiation. MR imaging disclosed an enhanced mass in the left frontal lobe, which was totally removed. Histological examination revealed glioblastoma multiforme. Patients with malignant lymphoma may develop a subsequent second malignant tumor. MR imaging with Gd-DTPA is quite useful for early detection of a second brain tumor.

Multicystic oligodendroglioma with calvarial destruction

“…Calvarial destruction with pre-existing glial tumor has been described in the presence of prior surgery and irradiation, often along iatrogenic violations of natural barrier to tumoral growth. [4][5][6][7][8][9][10] To our knowledge, invasion and destruction of the Calvaria from a oligodendroglioma, without prior surgery or radiation, and without macroscopic destruction of the dura mater, has not been described previously. Calvarial destruction with associated intraaxial lesion on imaging may prompt the diagnosis of extra-axial tumors such as aggressive meningioma, metastasis, and lymphoma.…”