Glioblastoma multiforme in the adult conus medullaris

Sanborn, Matthew R.; Pramick, Michelle; Brooks, John S.; Welch, William C.

doi:10.1016/j.jocn.2010.08.037

Cited by 11 publications

(5 citation statements)

References 11 publications

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“…Consequently, some authors argue that aggressive surgical management is unwarranted in spinal GBM. 64 For intramedullary GBM, extensive resection is often difficult because of ill- defined tumor margins from the spinal cord and adjacent tissues, with an overall poor prognosis regardless of the therapeutic intervention. Many institutions have resorted to diagnostic biopsy or limited resection followed by radiation and adjuvant chemotherapy given the risk of serious postoperative neurological complications.…”

Section: Prognosis and Treatmentmentioning

confidence: 99%

Leptomeningeal spinal metastases from glioblastoma multiforme: treatment and management of an uncommon manifestation of disease

Lawton

Nagasawa

Yang

et al. 2012

SPI

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Glioblastoma multiforme (GBM) is one of the most common and aggressive primary brain tumors, composing 12%–20% of all intracranial tumors in adults. Average life expectancy is merely 12–14 months following initial diagnosis. Patients with this neoplasm have one of the worst 5-year survival rates among all cancers despite aggressive multimodal treatment consisting of maximal tumor resection, radiation therapy, and adjuvant chemotherapy. With recent advancements in management strategies, there has been improvement in the overall trend in patient outcomes; however, recurrence remains nearly inevitable. While most tumors recur locally, metastases to distal locations have become more common. Specifically, the last decade has seen an increased incidence of spinal metastases, representing an emerging complication in patients with intracranial GBM. However, the literature regarding prevention strategies and the presentation of spinal metastases has remained scarce. As local control of primary lesions continues to improve, more cases of spinal metastases are likely to be seen. In this review the authors present a new case of metastatic GBM to the L-5 nerve root, and they summarize previous cases of intracranial GBM with leptomeningeal spinal metastatic disease. They also characterize key features of this disease presentation and discuss areas of future investigation necessary for enhanced prevention and treatment of this complication.

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Section: Prognosis and Treatmentmentioning

confidence: 99%

Leptomeningeal spinal metastases from glioblastoma multiforme: treatment and management of an uncommon manifestation of disease

Lawton

Nagasawa

Yang

et al. 2012

SPI

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“…In a literature review in 2011, the author found that conus medullaris is also a location where spinal GBM may generate, although it is not that usual. [21] A study retrospect 128 cases from 1938 to 2015 performed that 42.2% of spinal GBM were located in thoracic spine and 29.7% were in cervical spine. Meanwhile, tumors located in the conus level only accounted for 14%, according to this study.…”

Section: Discussionmentioning

confidence: 99%

Glioblastoma multiforme in conus medullaris with intracranial metastasis after postoperative adjuvant therapy

et al. 2017

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Spinal glioblastoma multiforme is not common among spinal cord tumors. According to our literature review, only 27 cases originating from the conus medullaris were reported. We herein reported a case of a 10-year-old child diagnosed with glioblastoma multiforme. The patient received adjuvant radiotherapy and standard temozolomide chemotherapy after total excision. Intracranial lesions were found 1 month after postoperative adjuvant therapy. We described the clinical characteristics and postoperative therapy of the patient, and reviewed all of the published cases of conus medullaris glioblastoma. Location, age, leptomeningeal spread, and secondary hydrocephalus may be predictive factors. Immunohistochemical factors such as p53 and Ki-67 are also important. Combined treatment of surgery and postoperative adjuvant therapy is commonly used, but is controversial.

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“…The high radiation doses required to obtain whole neural axis control for GBM, however, is a cause for concern. Two previous cases in the literature have received temozolomide for conus GBM and another received a combination of procarbazine, lomustine and vincristine [4,8,12]. This latter patient survived for a prolonged period (67 months) perhaps casting doubt on the accuracy of the original histological diagnosis.…”

Section: Accepted Manuscript -4 -mentioning

confidence: 95%

Primary glioblastoma multiforme of the conus medullaris with leptomeningeal metastasis

Nunn

Polyzoidis

Piechowski-Jóźwiak

et al. 2017

Journal of the Neurological Sciences

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Glioblastoma multiforme in the adult conus medullaris

Cited by 11 publications

References 11 publications

Leptomeningeal spinal metastases from glioblastoma multiforme: treatment and management of an uncommon manifestation of disease

Leptomeningeal spinal metastases from glioblastoma multiforme: treatment and management of an uncommon manifestation of disease

Glioblastoma multiforme in conus medullaris with intracranial metastasis after postoperative adjuvant therapy

Primary glioblastoma multiforme of the conus medullaris with leptomeningeal metastasis

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