Glioblastoma Multiforme in Children: Report of 13 Cases and Review of the Literature

Mahvash, Mehran; Hugo, Heinz-Hermann; Maslehaty, Homajoun; Mehdorn, H. Maximilian; Stark, Andreas M.

doi:10.1016/j.pediatrneurol.2011.05.004

Cited by 43 publications

(46 citation statements)

References 12 publications

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“…The survival time after GBM was 38 weeks (1-100) in the present study. This duration is shorter than de novo GBMs (119 weeks) (18). The mean radiation dose was 2058 cGy (1200-4800).…”

Section: Literature Reviewmentioning

confidence: 87%

Glioblastoma after radiotherapy for childhood acute lymphoblastic leukemia: Review

Kuzhan¹

2015

Gaziantep Med J

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Induction of neoplasia after therapeutic irradiation is well recognized. The development of the glioblastoma has been documented less frequently in association with radiation therapy. Pediatric patients with acute lymphoblastic leukemia are more susceptible to radiation-induced complications than adult patients. Postradiation glioblastomas in childhood acute lymphoblastic leukemia have poor prognosis. Treating postradiation glioblastomas are challenging for pediatric neuro-oncologists because of their more aggressive course than primary glioblastomas. To improve survival ratios and quality of life new researches are required in this treatment field. The goal of this review is to discuss the possible risk factors for radiation-induced tumorgenesis and histopathological characteristics.

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“…The survival time after GBM was 38 weeks (1-100) in the present study. This duration is shorter than de novo GBMs (119 weeks) (18). The mean radiation dose was 2058 cGy (1200-4800).…”

Section: Literature Reviewmentioning

confidence: 87%

Glioblastoma after radiotherapy for childhood acute lymphoblastic leukemia: Review

Kuzhan¹

2015

Gaziantep Med J

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“…A cutoff score of 80 generally differentiates good performance status from the poorly performing patients. In addition, neurological function scale (NFS) is another similar assessment tool in children (10). In our own study, the prognostic significance of preoperative performance status of these patients on the postoperative outcome was clearly demonstrated (4).…”

Section: Clinical Featuresmentioning

confidence: 95%

“…The OS in p-GBM varies from 10 to 73 months (2,4,6,(9)(10)(11)(12). Majority of the studies emphasize on improved survival figures in p-GBM compared with the adults (4, 9-11).…”

Section: Factors Affecting Outcomementioning

confidence: 99%

“…Nevertheless, GBM remains an equally devastating disease in children with substantial morbidity and mortality. The reported median survival in p-GBM ranges from 13 to 73 months with a 5-year survival of less than 20% (2,4,6,(9)(10)(11)(12)(13). A few reports, however, reveal a relatively better prognosis and long-term survival figures in p-GBM as compared with adults (4,(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

“…In fact, no such standard exists in children although a similar management policy is employed by most neurosurgeons across the globe. While there is sufficient evidence for the prognostic impact of maximal surgical excision of the visible tumor mass (4,9,10,14), the concerns of irradiation on the developing brain and contradictory results of various chemotherapy regimens in p-GBM make the treatment decisions rather complicated and difficult in children.…”

Section: Introductionmentioning

confidence: 99%

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Pediatric Glioblastoma

Das¹,

Kumar²

2017

Glioblastoma

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Glioblastoma in children, when compared with adults, is relatively rare. Despite this rarity, it is apparent from the limited number of publications that pediatric glioblastoma is quite distinct from their adult counterparts. The differences pertain to the molecular genetics, effectiveness of the adjuvant therapies, and possibly the prognosis after treatment. With a plethora of path-breaking translational research coming through in recent times, a host of new information is now available on pediatric glioblastomas that holds great promise as far as the future treatment options are concerned. This chapter is an attempt to highlight the key clinical aspects of pediatric glioblastoma in the light of the emerging clinical and laboratory evidence.

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Extent of Tumor Resection and Survival in Pediatric Patients With High-Grade Gliomas

et al. 2022

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IMPORTANCE Pediatric patients with high-grade gliomas have a poor prognosis. The association among the extent of resection, tumor location, and survival in these patients remains unclear.OBJECTIVE To ascertain whether gross total resection (GTR) in hemispheric, midline, or infratentorial pediatric high-grade gliomas (pHGGs) is independently associated with survival differences compared with subtotal resection (STR) and biopsy at 1 year and 2 years after tumor resection.DATA SOURCES PubMed, EBMR, Embase, and MEDLINE were systematically reviewed from inception to June 3, 2022, using the keywords high-grade glioma, pediatric, and surgery. No period or language restrictions were applied.STUDY SELECTION Randomized clinical trials and cohort studies of pHGGs that stratified patients by extent of resection and reported postoperative survival were included for study-level and individual patient data meta-analyses. DATA EXTRACTION AND SYNTHESISStudy characteristics and mortality rates were extracted from each article. Relative risk ratios (RRs) were pooled using random-effects models. Individual patient data were evaluated using multivariate mixed-effects Cox proportional hazards regression modeling. The PRISMA reporting guideline was followed, and the study was registered a priori. MAIN OUTCOMES AND MEASURESHazard ratios (HRs) and RRs were extracted to indicate associations among extent of resection, 1-year and 2-year postoperative mortality, and overall survival. RESULTSA total of 37 studies with 1387 unique patients with pHGGs were included. In study-level meta-analysis, GTR had a lower mortality risk than STR at 1 year (RR, 0.69; 95% CI, 0.56-0.83; P < .001) and 2 years (RR, 0.74; 95% CI, 0.67-0.83; P < .001) after tumor resection. Subtotal resection was not associated with differential survival compared with biopsy at 1 year (RR, 0.82; 95% CI, 0.66-1.01; P = .07) but had decreased mortality risk at 2 years (RR, 0.89; 95% CI, 0.82-0.97; P = .01). The individual patient data meta-analysis of 27 articles included 427 patients (mean [SD] age at diagnosis, 9.3 [5.9] years), most of whom were boys (169 of 317 [53.3%]), had grade IV tumors (246 of 427 [57.7%]), and/or had tumors that were localized to either the cerebral hemispheres (133 of 349 [38.1%]) or midline structures (132 of 349 [37.8%]). In the multivariate Cox proportional hazards regression model, STR (HR, 1.91; 95% CI, 1.34-2.74; P < .001) and biopsy (HR, 2.10; 95% CI, 1.43-3.07; P < .001) had shortened overall survival compared with GTR but no survival differences (continued) Key Points Question Is the extent of tumor resection associated with survival in pediatric patients with highgrade gliomas? Findings In this systematic review and meta-analysis of 37 studies involving 1387 unique pediatric patients with high-grade gliomas, gross total resection was independently associated with better overall survival compared with subtotal resection and biopsy, especially in patients with hemispheric and infratentorial tumors. Meaning Findings of this study suggest that m...

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Glioblastoma Multiforme in Children: Report of 13 Cases and Review of the Literature

Cited by 43 publications

References 12 publications

Glioblastoma after radiotherapy for childhood acute lymphoblastic leukemia: Review

Glioblastoma after radiotherapy for childhood acute lymphoblastic leukemia: Review

Pediatric Glioblastoma

Extent of Tumor Resection and Survival in Pediatric Patients With High-Grade Gliomas

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