Glioblastoma multiforme in a patient with common variable immunodeficiency and multiple malignancies – a case report

Abstract

A case of glioblastoma multiforme in female patient suffering from common variable immune deficiency syndrome is presented. The patient with history of previously treated due to breast carcinoma and ovarian cancer. The patient underwent craniotomy twice followed by radiotherapy and chemotherapy with temozolomide and finally died after 11 months. Keywords: common variable immune deficiency; glioblastoma multiforme.ABSTRAKT W artykule zaprezentowano przypadek 53-letniej kobiety z glejakiem wielopostaciowym, która leczona była uprzednio z powodu raka przydatków oraz raka przewodowego piersi. Chorą leczono z powodu pospolitego zmiennego niedoboru odporności podawaniem immunoglobuliny. Poddana 2-krotnie resekcji guza mózgu i radioterapii oraz chemioterapii (temozolamid), zmarła po 11 miesiącach. Słowa kluczowe: pospolity zmienny niedobór odporności; glejak wielopostaciowy.

The Pathophysiology of Post-Traumatic Glioma

“…Some researchers argue that they play this role in all gliomas [ 21 , 22 , 23 ]. Our own observations in a female patient with recurrent glioma in the occipital lobe revealed changes in the density of the white matter of the brain, spreading radially from the tumor bed in the period preceding the formation of GBM [ 24 ]. As surgical procedure included all elements of cerebral trauma, it could be considered as stimulating tumor growth.…”