Glimpsing the chemical composition and the potential of Myrtaceae plant extracts against the food spoilage fungus Thielaviopsis ethacetica

Duarte, Jorge; Alves-Ribeiro, Gabrielle; Machado, Francisco Paiva; Folly, Diogo; Peñaloza, Evelyn Maribel Condori; Santos, Marcelo Guerra; Ventura, José Aires; Wermelinger, Guilherme Freimann; Robbs, Bruno Kaufmann; Rocha, Leandro; Fiaux, Sorele Batista

doi:10.1016/j.foodcont.2022.109501

Cited by 3 publications

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“…Previous studies described the pharmacological properties of this essential oil with insecticidal and anticholinesterase effects [ 21 , 22 , 23 ]. Other authors described the antiproliferative, antioxidant, antifungal, antibacterial, anti-inflammatory, and antinociceptive effects of different extract fractions from this plant [ 19 , 24 , 25 , 26 ]. Based on this scenario, this work aims to obtain a novel nanoemulsion with molluscicidal and cercaricidal activity from the essential oil of Myrciaria floribunda leaves as an alternative against Biomphalaria glabrata and Schistosoma mansoni to control schistosomiasis.…”

Section: Introductionmentioning

confidence: 99%

Molluscicidal and Cercaricidal Effects of Myrciaria floribunda Essential Oil Nanoemulsion

et al. 2023

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Schistosomiasis is a tropical disease transmitted in an aqueous environment by cercariae from the Schistosoma genus. This disease affects 200 million people living in risk areas around the world. The control of schistosomiasis is realized by chemotherapy, wastewater sanitation, health education, and mollusk control using molluscicidal agents. This work evaluates the effects of a nanoemulsion containing essential oil from Myrciaria floribunda leaves as a molluscicidal and cercaricidal agent against Biomphalaria glabrata mollusks and Schistosoma mansoni cercariae. The Myrciaria floribunda essential oil from leaves showed nerolidol, β-selinene, 1,8 cineol, and zonarene as major constituents. The formulation study suggested the F3 formulation as the most promising nanoemulsion with polysorbate 20 and sorbitan monooleate 80 (4:1) with 5% (w/w) essential oil as it showed a smaller droplet size of approximately 100 nm with a PDI lower than 0.3 and prominent bluish reflection. Furthermore, this nanoemulsion showed stability after 200 days under refrigeration. The Myrciaria floribunda nanoemulsion showed LC50 values of 48.11 µg/mL, 29.66 µg/mL, and 47.02 µg/mL in Biomphalaria glabrata embryos, juveniles, and adult mollusks, respectively, after 48 h and 83.88 µg/mL for Schistosoma mansoni cercariae after 2 h. In addition, a survival of 80% was observed in Danio rerio, and the in silico toxicity assay showed lower overall human toxicity potential to the major compounds in the essential oil compared to the reference molluscicide niclosamide. These results suggest that the nanoemulsion of Myrciaria floribunda leaves may be a promising alternative for schistosomiasis control.

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