Abstract:TBI heterogeneity is recognized as a major impediment to successful translation of therapies that could improve morbidity and mortality after injury. This heterogeneity exists on multiple levels including primary injury, secondary injury/host-response, and recovery. One widely accepted type of primary-injury related heterogeneity is pathoanatomic—the intracranial compartment that is predominantly affected, which can include any combination of subdural, subarachnoid, intraparenchymal, diffuse axonal, intraventr… Show more
“…This approach represents a promising current and future direction for TBI research (12). For example, IV glyburide may reduce the volume of edema and hemorrhage following contusional TBI (13). The Antagonizing SUR1-TRPM4 to Reduce the progression of intracerebral hematoma And edema surrounding Lesions (ASTRAL) multicenter phase II clinical trial, therefore, sought to evaluate its effect on patients with the pathoanatomical endophenotype of brain contusion (14).…”
“…This approach represents a promising current and future direction for TBI research (12). For example, IV glyburide may reduce the volume of edema and hemorrhage following contusional TBI (13). The Antagonizing SUR1-TRPM4 to Reduce the progression of intracerebral hematoma And edema surrounding Lesions (ASTRAL) multicenter phase II clinical trial, therefore, sought to evaluate its effect on patients with the pathoanatomical endophenotype of brain contusion (14).…”
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