Abstract:IntroductionEvidence suggests a role for Central nervous system glia in pain transmission and in augmenting maladaptive opioid effects. Identification of drugs that modulate glia has guided the evaluation of glial suppression as a pain management strategy. This planned systematic review will describe evidence of the efficacy and adverse effects of glial-modulating drugs in pain management.Methods and analysisA detailed search will be conducted on the Cochrane Central Register of Controlled Trials, Medline, and… Show more
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