Glial-derived neurotrophic factor in human adult and fetal intestine and in Hirschsprung's disease

Bär, Karl Jürgen; Facer, P.; Williams, Norman S.; Tam, Paul Kwong‐Hang; Anand, Praveen

doi:10.1016/s0016-5085(97)70154-9

Cited by 60 publications

(33 citation statements)

References 1 publication

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“…It serves as chemoattractant to guide NCSC along the gut and maintains a suitable environment for the survival and differentiation [64,65]. In tissue samples from patients with HSCR, a reduced GDNF immunoreactivity in the aganglionated bowel was described [33,34,63]. Usually, these studies are based on immunohistochemical staining and low patient numbers.…”

Section: Discussionmentioning

confidence: 99%

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The microenvironment in the Hirschsprung's disease gut supports myenteric plexus growth

Hagl

Rauch²,

Klotz³

et al. 2012

Int J Colorectal Dis

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The amount of the factors varied considerably between the individual segments and also from patient to patient. Four major expression patterns could be detected. While all extracts tested lead to a significant increase in neurite outgrowth compared to the control, extracts from proximal segments tended to have more prominent effects. In one experiment, extracts from all individual segments of a single patient were tested. Neurite outgrowth, neuronal survival, and branching pattern varied from segment to segment, but all HSCR-muscle-protein extracts increased neuronal survival and network formation. Smooth muscle protein from aganglionic bowel supports the survival and outgrowth of myenteric neurons and NCSCs and is so an appropriate target for neural stem cell treatment.

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Section: Discussionmentioning

confidence: 99%

“…Mutations of the tyrosine kinase RET, the common signaling receptor of all GDNF related ligands, account for 50% of familial HSCR [30]. A lack of GDNF itself leads to the complete absence of enteric neurons in mice [31,32], while its role in HSCR is not clear up to now [30,33,34].…”

Section: Introductionmentioning

confidence: 99%

The microenvironment in the Hirschsprung's disease gut supports myenteric plexus growth

Hagl

Rauch²,

Klotz³

et al. 2012

Int J Colorectal Dis

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“…Loss or dysfunction of EGCs leads to substantial degeneration of myenteric neurons, which may be due to loss of trophic or neuroprotective functions; for example, EGC produce glial-derived neurotrophic factor 55. Also, enteric neurons, like CNS neurons, are vulnerable to glutamate-mediated excitotoxicity,56 and in the CNS, disruption of glutamate uptake by astrocytes causes excitotoxic neuronal death 57.…”

Section: Discussionmentioning

confidence: 99%

The brain to gut pathway: a possible route of prion transmission

Lawson

Furness

Klemm

et al. 2010

Gut

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The present work shows that PrP(Sc) can be transmitted from the brain to the intestine. This causes pathological changes in enteric glia and neurons. We conclude that PrP(Sc) of brain origin finds a substrate in the naturally occurring PrP(C) of EGCs and neurons. This results in a reservoir of PrP(Sc) in the intestine, which may represent a source of prion disease transmission through surgical procedures and environmental contamination.

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“…25 Moreover, it has been shown that mature EGC produce GDNF. 26 So far, it has not been demonstrated that glial expression of trophic factors contributes to the maintenance of enteric neurons in man. However, several such lines of evidence are available for animal models.…”

Section: Putative Mechanisms For Egc Influence On Gastrointestinal Momentioning

confidence: 99%

Enteric glial cells: new players in gastrointestinal motility?

Bassotti

Villanacci

Antonelli

et al. 2007

Laboratory Investigation

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The enteric glial cells, in addition to being support structures for the enteric nervous system, have many other additional roles, such as modulators for the homeostasis of enteric neurons, cells involved in enteric neurotransmission and antigenpresenting cells. Moreover, in the last years, data have been accumulating that demonstrate a possible active role of these cells in the pathophysiology of gastrointestinal motor activity. Thus, as also shown by recent evidence in both experimental animal models, and in some human diseases, alterations of enteric glial cells might have some role in the development of intestinal motor abnormalities.

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Glial-derived neurotrophic factor in human adult and fetal intestine and in Hirschsprung's disease

Cited by 60 publications

References 1 publication

The microenvironment in the Hirschsprung's disease gut supports myenteric plexus growth

The microenvironment in the Hirschsprung's disease gut supports myenteric plexus growth

The brain to gut pathway: a possible route of prion transmission

Enteric glial cells: new players in gastrointestinal motility?

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