Glial Changes in Pigs With Porto‐caval Anastomosis and Temporary or Total Hepatic Artery Clamping

Diemer, Nils Henrik; Tønnesen, K. H.

doi:10.1111/j.1699-0463.1977.tb00464.x

Cited by 4 publications

(2 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Diemer and Tonnesen investigated glial changes following portocaval anastomosis (PCA) and either total or partial hepatic artery clamping/devascularization [ 103 ]. Utilizing H&E staining, they reported no astrocyte changes following PCA and total hepatic devascularization.…”

Section: Previous Investigations Of Porcine Astrocytes In Neurotrauma...mentioning

confidence: 99%

Porcine Astrocytes and Their Relevance for Translational Neurotrauma Research

Purvis,

Fedorczak,

Prah

et al. 2023

Biomedicines

View full text Add to dashboard Cite

Astrocytes are essential to virtually all brain processes, from ion homeostasis to neurovascular coupling to metabolism, and even play an active role in signaling and plasticity. Astrocytic dysfunction can be devastating to neighboring neurons made inherently vulnerable by their polarized, excitable membranes. Therefore, correcting astrocyte dysfunction is an attractive therapeutic target to enhance neuroprotection and recovery following acquired brain injury. However, the translation of such therapeutic strategies is hindered by a knowledge base dependent almost entirely on rodent data. To facilitate additional astrocytic research in the translatable pig model, we present a review of astrocyte findings from pig studies of health and disease. We hope that this review can serve as a road map for intrepid pig researchers interested in studying astrocyte biology.

show abstract

Section: Previous Investigations Of Porcine Astrocytes In Neurotrauma...mentioning

confidence: 99%

Porcine Astrocytes and Their Relevance for Translational Neurotrauma Research

Purvis,

Fedorczak,

Prah

et al. 2023

Biomedicines

View full text Add to dashboard Cite

show abstract

“…However, with the exception of horses, the formation of AIIA is generally less frequent in animals than in humans 2 . AIIA have also been reported in porcine brains after devascularisation of the liver by experimental portocaval anastomosis and clamping of the hepatic artery 5 . AIIA karyomegaly is reported to occur only in brains fixed by immersion, with no significant enlargement in perfusion‐fixed material 6 .…”

mentioning

confidence: 98%

Alzheimer type II astrocytes in the brains of pigs with salt poisoning (water deprivation/intoxication)

Finnie

Blumbergs

Williamson³

2010

Aust Veterinary J

View full text Add to dashboard Cite

show abstract

Quantitation and karyometry of cerebral neuroglia and endothelial cells in liver cirrhosis and in the hepatosplenic schistosomiasis mansoni

Brasileiro-Filho¹,

Guimarães

Pittella³

1989

Acta Neuropathol

View full text Add to dashboard Cite

A morphological, karyometric, and quantitative study of cerebral neuroglia and endothelial cells of blood capillaries was done in cirrhotic and in hepatosplenic schistosomotic human autopsied cases. Cluster analysis applied to them revealed three subgroups (cirrhosis and schistosomiasis polar groups and one intermediate). The comparison of these three groups with a control revealed increased numbers of astrocytes, oligodendrocytes and endothelial cells, but no nuclear enlargement in the schistosomiasis group; the cirrhosis group exhibited a pronounced nuclear enlargement of both astrocyte and oligodendrocytes but no increase in cell numbers. The intermediate group, which encompasses the majority of pathological cases, is heterogeneous but on average behave as the cirrhosis group in that nuclear enlargement, but no increase in cell numbers, was noted. Such changes could represent a response of the nervous system to the metabolic disturbances present in hepatic and/or portal-systemic encephalopathy. There was a positive correlation between glial and endothelial cell numbers in cerebral cortex, suggesting a functional relationship between the glial cells and the capillary bed. This study points out the importance of clustering the cases, because the physiopathological status of individuals belonging to the same nosological condition can be different. Comparisons considering this aspect should be useful in understanding the progression of the pathological process.

show abstract

Glial Changes in Pigs With Porto‐caval Anastomosis and Temporary or Total Hepatic Artery Clamping

Cited by 4 publications

References 22 publications

Porcine Astrocytes and Their Relevance for Translational Neurotrauma Research

Porcine Astrocytes and Their Relevance for Translational Neurotrauma Research

Alzheimer type II astrocytes in the brains of pigs with salt poisoning (water deprivation/intoxication)

Quantitation and karyometry of cerebral neuroglia and endothelial cells in liver cirrhosis and in the hepatosplenic schistosomiasis mansoni

Contact Info

Product

Resources

About