“…Interestingly, similar to the findings of the present study, post-mortem studies in schizophrenia subjects have revealed smaller volumes of frontal, parietal, and temporal cortices (Pakkenberg, 1993;Selemon et al, 2002), lower glial cell (area 24) (Stark et al, 2004) and oligodendrocyte number (area 9) (Hof et al, 2003), higher neuron density in the dorsolateral prefrontal (area 9), anterior cingulate (area 24), and primary visual (area 17) cortices (Chana et al, 2003;Selemon et al, 1995), and no change in total neuron number in the prefrontal (Thune et al, 2001) or total neocortex (Pakkenberg, 1993) relative to normal comparison subjects. However, whereas treatment with typical antipsychotics has been reported to lead to smaller volumes in certain cortical areas in subjects with schizophrenia (Dazzan et al, 2005;Lieberman et al, 2005), atypical antipsychotics might preserve cortical volume (Dazzan et al, 2005) or slow the rate of volume decreases (Lieberman et al, 2005).…”