Glial cell line-derived neurotrophic factor receptor α1 availability regulates glial cell line-derived neurotrophic factor signaling: evidence from mice carrying one or two mutated alleles

Tomac, Andreas C.; Grinberg, Alexander; Huang, Shuhong; Nosrat, Christopher A.; Wang, Y.; Borlongan, Cesario V.; Lin, Shinn‐Zong; Chiang, Yung Hsiao; Olson, Lar̀s; Westphal, Heiner; Hoffer, Barry J.

doi:10.1016/s0306-4522(99)00503-5

Cited by 99 publications

(58 citation statements)

References 48 publications

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“…The ureteric bud, kidney and enteric neurons are absent Pichel et al, 1996;Sanchez et al, 1996). The Ret and Gfrα-1 receptors have also been knocked out and show the same phenotypes, indicating that Gdnf signals through the Gfrα-1/Ret-receptor complex and is essential for postnatal survival in the mouse (Schuchardt et al, 1994;Enomoto et al, 1998;Cacalano et al, 1998;Tomac et al, 2000). Interestingly, the testicular morphology of mice lacking Gdnf, Gfrα-1 and Ret is normal before birth.…”

Section: Role Of Gdnf In the Mammalian Testismentioning

confidence: 99%

Gdnf signaling pathways within the mammalian spermatogonial stem cell niche

Hofmann

2008

Molecular and Cellular Endocrinology

203

178

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SummaryMammalian spermatogenesis is a complex process in which male germ-line stem cells develop to ultimately form spermatozoa. Spermatogonial stem cells, or SSCs, are found in the basal compartment of the seminiferous epithelium. They self-renew to maintain the pool of stem cells throughout life, or they differentiate to generate a large number of germ cells. A balance between SSC self-renewal and differentiation in the adult testis is therefore essential to maintain normal spermatogenesis and fertility. Maintenance and self-renewal are tightly regulated by extrinsic signals from the surrounding microenvironment, called the spermatogonial stem cell niche. By physically supporting the SSCs and providing them with growth factors, the Sertoli cell is the main component of the niche. In addition, adhesion molecules that connect the SSCs to the basement membrane and cellular components of the interstitium between the seminiferous tubules are important regulators of the niche function. This review mainly focuses on glial cell line-derived neurotrophic factor (Gdnf), which is produced by Sertoli cells to maintain SSCs self-renewal, and the downstream signaling pathways induced by this crucial growth factor. Interactions between Gdnf and other signaling pathways that maintain self-renewal, as well as the role of novel SSC-and Sertoli cell-specific transcription factors, are also discussed.

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Section: Role Of Gdnf In the Mammalian Testismentioning

confidence: 99%

Gdnf signaling pathways within the mammalian spermatogonial stem cell niche

Hofmann

2008

Molecular and Cellular Endocrinology

203

178

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“…Mutations of any of these three genes result in renal agenesis [24][25][26]. Mutations of transcription factor genes that regulate expression of GDNF (e.g., Eya1 or Hox11) or Ret (e.g., Gata3) also cause renal agenesis or hypoplasia [27][28][29].…”

Section: Mammalian Kidney Developmentmentioning

confidence: 99%

Planar Cell Polarity Pathway in Kidney Development and Function

Rocque

Torban

2015

Advances in Nephrology

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The evolutionarily conserved planar cell polarity (PCP) signaling pathway controls tissue polarity within the plane orthogonal to the apical-basal axis. PCP was originally discovered in Drosophila melanogaster where it is required for the establishment of a uniform pattern of cell structures and appendages. In vertebrates, including mammals, the PCP pathway has been adapted to control various morphogenetic processes that are critical for tissue and organ development. These include convergent extension (crucial for neural tube closure and cochlear duct development) and oriented cell division (needed for tubular elongation), ciliary tilting that enables directional fluid flow, and other processes. Recently, strong evidence has emerged to implicate the PCP pathway in vertebrate kidney development. In this review, we will describe the experimental data revealing the role of PCP signaling in nephrogenesis and kidney disease.

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“…They play important roles in the survival, proliferation, and differentiation of different subtypes of neurons, and in the development of other types of tissues and cells such as the kidney and spermatogonia (Airaksinen and Saarma, 2002). The phenotype of the nervous system of mice lacking GFLs or their receptors indicated that (1) GDNF plays an essential role in the development of the enteric nervous system and may also play a role in the development of sympathetic and sensory neurons (Moore et al, 1996;Pichel et al, 1996;Sanchez et al, 1996;Cacalano et al, 1998;Enomoto et al, 1998;Tomac et al, 2000); (2) neurturin plays an important role in the development of subpopulations of parasympathetic, sensory, and enteric neurons (Heuckeroth et al, 1999;Rossi et al, 1999;Hiltunen et al, 2000); and (3) artemin plays a role in the development of sympathetic ganglia (Nishino et al, 1999;Honma et al, 2002). In vitro studies of peripheral neurons have shown that GDNF promotes the proliferation of enteric neural precursors and the survival and differentiation of enteric, sympathetic, parasympathetic, and sensory neurons (Trupp et al, 1995;Chalazonitis et al, 1998;Hearn et al, 1998;Heuckeroth et al, 1998;Forgie et al, 1999;Taraviras et al, 1999;Thang et al, 2000;Worley et al, 2000); neurturin promotes the survival and differentiation of sympathetic, parasympathetic, enteric, and sensory neurons (Kotzbauer et al, 1996;Matheson et al, 1997;Milbrandt et al, 1998;Forgie et al, 1999;Taraviras et al, 1999;Thang et al, 2000); and artemin supports the survival of sensory and sympathetic neurons Andres et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Developmental changes in neurite outgrowth responses of dorsal root and sympathetic ganglia to GDNF, neurturin, and artemin

Yan

Newgreen

Young

2003

Developmental Dynamics

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The ability of glial cell line-derived neurotrophic factor (GDNF), neurturin, and artemin to induce neurite outgrowth from dorsal root, superior cervical, and lumbar sympathetic ganglia from mice at a variety of development stages between embryonic day (E) 11.5 and postnatal day (P) 7 was examined by explanting ganglia onto collagen gels and growing them in the presence of agarose beads impregnated with the different GDNF family ligands. Artemin, GDNF, and neurturin were all capable of influencing neurite outgrowth from dorsal root and sympathetic ganglia, but the responses of each neuron type to the different ligands varied during development. Neurites from dorsal root ganglia responded to artemin at P0 and P7, to GDNF at E15.5 and P0, and to neurturin at E15.5, P0, and P6/7; thus, artemin, GDNF, and neurturin are all capable of influencing neurite outgrowth from dorsal root ganglion neurons. Neurites from superior cervical sympathetic ganglia responded significantly to artemin at E15.5, to GDNF at E15.5 and P0, and to neurturin at E15.5. Neurites from lumbar sympathetic ganglia responded to artemin at all stages from E11.5 to P7, to GDNF at P0 and P7 and to neurturin at E11.5 to P6/7. Combined with the data from previous studies that have examined the expression of GDNF family members, our data suggest that artemin plays a role in inducing neurite outgrowth from young sympathetic neurons in the early stages of sympathetic axon pathfinding, whereas GDNF and neurturin are likely to be important at later stages of sympathetic neuron development in inducing axons to enter particular target tissues once they are in the vicinity or to induce branching within target tissues. Superior cervical and lumbar sympathetic ganglia showed temporal differences in their responsiveness to artemin, GDNF, and neurturin, which probably partly reflects the rostrocaudal development of sympathetic ganglia and the tissues they innervate.

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Glial cell line-derived neurotrophic factor receptor α1 availability regulates glial cell line-derived neurotrophic factor signaling: evidence from mice carrying one or two mutated alleles

Cited by 99 publications

References 48 publications

Gdnf signaling pathways within the mammalian spermatogonial stem cell niche

Gdnf signaling pathways within the mammalian spermatogonial stem cell niche

Planar Cell Polarity Pathway in Kidney Development and Function

Developmental changes in neurite outgrowth responses of dorsal root and sympathetic ganglia to GDNF, neurturin, and artemin

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