Gliadin-mediated green preparation of hybrid zinc oxide nanospheres with antibacterial activity and low toxicity

Abstract

The development of inorganic antibacterial agents that impart antibacterial properties to biomaterials has attracted wide attention. The paper introduced a kind of hybrid nanosphere antibacterial agent composed of wheat gliadin (WG) and zinc oxide (ZnO), with antibacterial efficacy and low toxicity. The ZnO/WG hybrid nanospheres were environment-friendly integrated by molecular self-assembly co-precipitating and freeze-drying transformation, and were characterized using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), atomic absorption spectroscopy (AAS), specific surface and pore size analysis, bacteriostasis test, reactive oxygen species (ROS) determination and safety evaluation. It was found that the prepared hybrid nanospheres were composed of two components, WG and ZnO, with a diameter scope of 100–200 nm; the content of ZnO in the hybrid nanospheres can reach 46.9–70.2% (w/w); the bacteriostasis tests proved that the prepared ZnO/WG nanospheres generating ROS, have a significant inhibitory effect on E. coli and S. aureus; furthermore, the ZnO/WG nanospheres are relatively safe and highly biocompatible in cells and mice. Therefore, the prepared novel ZnO/WG hybrid nanospheres were supposed to apply in the preparation of anti-infective wound dressings, tissue engineering skin scaffold materials, food, and cosmetics preservatives, and so on.

The Antibacterial Activities and Characterizations of Biosynthesized Zinc Oxide Nanoparticles, and Their Coated with Alginate Derived from Fucus vesiculosus

“…The sodium alginate contains evenly dispersed nano-ZnO [ 69 ]. The shapes of ZnO/WG (wheat gliadin) nanospheres were nearly spherical [ 70 ].…”

Fabrication of Carbon and Related Materials/Metal Hybrids and Composites

“…As presented in Table 3, and as stated by the different reports, all hybrid systems showed higher surface areas than those of bare metal oxides. Highly dispersed ZnO NPs supported on the silica gel matrix 245 [89] Cellulose/ZnO hybrid aerogel (CA/ZnO) 352.82 [90] Wheat gliadin/ZnO hybrid nanospheres 523.88 [91] 3.5. AFM Topographical Analysis of the Synthesized Carbopol/ZnO Hybrid Nanoparticles Gel Figure 6a-d shows the non-contact mode topographical AFM 2D images and the corresponding 3D images for the synthesized Carbopol/ZnO hybrid nanoparticles gel.…”