Glia Signaling and Brain Microenvironment in Migraine

Amani, Hanieh; Khaboushan, Alireza Soltani; Terwindt, Gisela M.; Tafakhori, Abbas

doi:10.1007/s12035-023-03300-3

Cited by 6 publications

(3 citation statements)

References 281 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, direct neuron–glia communication is facilitated through two-way calcium signaling, primarily via purinergic P2 receptors (notably P2X7) and gap junctions ( 39 ). This intricate neuron–glia dialogue intensifies pain signaling and contributes to central sensitization ( 41 , 42 ).…”

Section: Neuroinflammation In Migrainementioning

confidence: 99%

Neuroimmunological effects of omega-3 fatty acids on migraine: a review

Chen,

Yang,

Tsai

et al. 2024

Front. Neurol.

View full text Add to dashboard Cite

Migraine is a highly prevalent disease worldwide, imposing enormous clinical and economic burdens on individuals and societies. Current treatments exhibit limited efficacy and acceptability, highlighting the need for more effective and safety prophylactic approaches, including the use of nutraceuticals for migraine treatment. Migraine involves interactions within the central and peripheral nervous systems, with significant activation and sensitization of the trigeminovascular system (TVS) in pain generation and transmission. The condition is influenced by genetic predispositions and environmental factors, leading to altered sensory processing. The neuroinflammatory response is increasingly recognized as a key event underpinning the pathophysiology of migraine, involving a complex neuro-glio-vascular interplay. This interplay is partially mediated by neuropeptides such as calcitonin gene receptor peptide (CGRP), pituitary adenylate cyclase activating polypeptide (PACAP) and/or cortical spreading depression (CSD) and involves oxidative stress, mitochondrial dysfunction, nucleotide-binding domain-like receptor family pyrin domain containing-3 (NLRP3) inflammasome formation, activated microglia, and reactive astrocytes. Omega-3 polyunsaturated fatty acids (PUFAs), particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), crucial for the nervous system, mediate various physiological functions. Omega-3 PUFAs offer cardiovascular, neurological, and psychiatric benefits due to their potent anti-inflammatory, anti-nociceptive, antioxidant, and neuromodulatory properties, which modulate neuroinflammation, neurogenic inflammation, pain transmission, enhance mitochondrial stability, and mood regulation. Moreover, specialized pro-resolving mediators (SPMs), a class of PUFA-derived lipid mediators, regulate pro-inflammatory and resolution pathways, playing significant anti-inflammatory and neurological roles, which in turn may be beneficial in alleviating the symptomatology of migraine. Omega-3 PUFAs impact various neurobiological pathways and have demonstrated a lack of major adverse events, underscoring their multifaceted approach and safety in migraine management. Although not all omega-3 PUFAs trials have shown beneficial in reducing the symptomatology of migraine, further research is needed to fully establish their clinical efficacy and understand the precise molecular mechanisms underlying the effects of omega-3 PUFAs and PUFA-derived lipid mediators, SPMs on migraine pathophysiology and progression. This review highlights their potential in modulating brain functions, such as neuroimmunological effects, and suggests their promise as candidates for effective migraine prophylaxis.

show abstract

Section: Neuroinflammation In Migrainementioning

confidence: 99%

Neuroimmunological effects of omega-3 fatty acids on migraine: a review

Chen,

Yang,

Tsai

et al. 2024

Front. Neurol.

View full text Add to dashboard Cite

show abstract

“…M1 microglia (biomarker: interleukin 1 beta (IL-1β), IL-6, tumor necrosis factor-alpha (TNF-α), etc.) [ 13 , 14 ] are a group of cells that mainly secrete pro-inflammatory cytokines and show pro-inflammatory functions. They can produce TNF-α, IL-1β, IL-6, and other inflammatory mediators, such as glutamic acid and nitric oxide (NO), initiate inflammatory reactions, and lead to apoptosis and secondary injury, showing pronounced neurotoxic effects.…”

Section: Microglia Astrocytes and Migrainesmentioning

confidence: 99%

Astrocyte-Microglia Crosstalk: A Novel Target for the Treatment of Migraine

et al. 2023

View full text Add to dashboard Cite

Migraine is a pervasive neurologic disease closely related to neurogenic inflammation. The astrocytes and microglia in the central nervous system are vital in inducing neurogenic inflammation in migraine. Recently, it has been found that there may be a crosstalk phenomenon between microglia and astrocytes, which plays a crucial part in the pathology and treatment of Alzheimer's disease and other central nervous system diseases closely related to inflammation, thus becoming a novel hotspot in neuroimmune research. However, the role of the crosstalk between microglia and astrocytes in the pathogenesis and treatment of migraine is yet to be discussed. Based on the preliminary literature reports, we have reviewed relevant evidence of the crosstalk between microglia and astrocytes in the pathogenesis of migraine and summarized the crosstalk pathways, thereby hoping to provide novel ideas for future research and treatment.

show abstract

“…All these changes occur with several microglial receptors, TLRs, triggering receptors expressed on myeloid cells, and mannose receptors 39 . Hyperalgesia in migraine is underlined by several aspects, including neurons–glia crosstalk and disturbing the balance of the neurotransmitters in the nervous system by microglia, astrocytes, and satellite cells can induce migraine headaches; 40 however, not all aspects of the involvement of microglia in migraine are clear.…”

Section: Neurons’ Interplay With Microglia In Migraine Pathogenesismentioning

confidence: 99%

Autophagy may protect the brain against prolonged consequences of headache attacks: A narrative/hypothesis review

Fila,

Pawlowska,

Szczepanska

et al. 2023

Headache

View full text Add to dashboard Cite

ObjectiveTo assess the potential of autophagy in migraine pathogenesis.BackgroundThe interplay between neurons and microglial cells is important in migraine pathogenesis. Migraine‐related effects, such as cortical spreading depolarization and release of calcitonin gene–related peptide, may initiate adenosine triphosphate (ATP)‐mediating pro‐nociceptive signaling in the meninges causing headaches. Such signaling may be induced by the interaction of ATP with purinergic receptor P2X 7 (P2X7R) on microglial cells leading to a Ca2+‐mediated pH increase in lysosomes and release of autolysosome‐like vehicles from microglial cells indicating autophagy impairment.MethodsA search in PubMed was conducted with the use of the terms “migraine,” “autophagy,” “microglia,” and “degradation” in different combinations.ResultsImpaired autophagy in microglia may activate secretory autophagy and release of specific proteins, including brain‐derived neurotrophic factor (BDNF), which can be also released through the pores induced by P2X7R activation in microglial cells. BDNF may be likewise released from microglial cells upon ATP‐ and Ca2+‐mediated activation of another purinergic receptor, P2X4R. BDNF released from microglia might induce autophagy in neurons to clear cellular debris produced by oxidative stress, which is induced in the brain as the response to migraine‐related energy deficit. Therefore, migraine‐related signaling may impair degradative autophagy, stimulate secretory autophagy in microglia, and degradative autophagy in neurons. These effects are mediated by purinergic receptors P2X4R and P2X7R, BDNF, ATP, and Ca2+.ConclusionDifferent effects of migraine‐related events on degradative autophagy in microglia and neurons may prevent prolonged changes in the brain related to headache attacks.

show abstract

Glia Signaling and Brain Microenvironment in Migraine

Cited by 6 publications

References 281 publications

Neuroimmunological effects of omega-3 fatty acids on migraine: a review

Neuroimmunological effects of omega-3 fatty acids on migraine: a review

Astrocyte-Microglia Crosstalk: A Novel Target for the Treatment of Migraine

Autophagy may protect the brain against prolonged consequences of headache attacks: A narrative/hypothesis review

Contact Info

Product

Resources

About