Glia-Mediated Antigen Presentation In The Retina During Degeneration
Simona Intonti,
Despina Kokona,
Martin S. Zinkernagel
et al.
Abstract:Glia antigen-presenting cells (APCs) are pivotal regulators of immune surveillance within the retina, maintaining tissue homeostasis and promptly responding to insults. The intricate mechanisms underlying their local coordination and activation remain unclear. Our study integrates an animal model of retinal injury, retrospective analysis of human retinas, and in vitro experiments to elucidate insights into the pivotal role of antigen presentation in neuroimmunology during retinal degeneration, uncovering the i… Show more
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