Glia Connect Inflammation and Neurodegeneration in Multiple Sclerosis

Sun, Ye; Yu, Hao; Guan, Yangtai

doi:10.1007/s12264-023-01034-9

Cited by 14 publications

(5 citation statements)

References 146 publications

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“…Так, очаги при РС в определенных случаях могут быть ошибочно приняты за накапливающие КВ гематогенные метастазы, а также за первичные опухоли головного мозга (при так называемой псевдотуморозной форме РС). При этом для опухолевых поражений более характерным считается «кольцевидный» тип их контрастирования, а для очагов демиелинизации при РС -«кольцевидно-разрывной» [23].…”

Section: критерии магнитно-резонансных проявлений поражений при рассе...unclassified

Modern possibilities of MRI-based diagnosis of multiple sclerosis. Literature review

Degtyarev,

Zavadovskaya,

Kurazhov

et al. 2024

Bûll. sib. med.

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Multiple sclerosis remains the most common demyelinating disease of the central nervous system and ranks first among neurological diseases that lead to disability in young people. The most important diagnostic and prognostic marker, especially at an early stage of the disease, is magnetic resonance imaging (MRI), which currently remains the only method that allows to explore the entire central nervous system in vivo.The review presents literature data on modern achievements in MRI-based diagnosis of multiple sclerosis. Key attention is paid to such promising methods as assessment of brain and spinal cord atrophy, brain perfusion MRI, and diffusion tensor imaging. Implementation of these approaches in MRI can help solve the problem of early diagnosis of multiple sclerosis and determine more reliable markers of a response to ongoing therapy.

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Section: критерии магнитно-резонансных проявлений поражений при рассе...unclassified

Modern possibilities of MRI-based diagnosis of multiple sclerosis. Literature review

Degtyarev,

Zavadovskaya,

Kurazhov

et al. 2024

Bûll. sib. med.

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“…The necessity of including immune cells in brain MPS became more indisputable as evidence of the role of immune responses in neurodegenerative diseases emerged, as reviewed by many. [55][56][57][58] An initial model containing central nervous system axons and one glia type, oligodendrocytes, was fabricated by Taylor et al in 2005. 59 This platform consisted of two compartments: a large well that allowed for the growth of soma, and narrow tunnels that allowed for CNS axon isolation and addition of oligodendrocytes.…”

Section: The Innate Immune System and The Central Nervous Systemmentioning

confidence: 99%

Section: The Innate Immune System and The Central Nervous Systemmentioning

confidence: 99%

Modelling the innate immune system in microphysiological systems

Rupar,

Hanson,

Rogers

et al. 2024

Lab Chip

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“…Cerutti et al [ 230 ] developed an in vitro technique for studying the interaction between BMECs with human leukocytes in a microfluidic model, which was coupled with live-cell imaging that could also be advantageous for leukocyte extravasation into the CNS in MS in vitro studies. It appears to be impossible to create a universal in vitro model for neuroinflammation in MS due to the reliance of adaptive and innate immune cells on the disease’s development, as well as due to the specific region of the brain that is affected [ 192 ].…”

Section: Disease-specific Modeling Of Neuroinflammationmentioning

confidence: 99%

Blood–Brain Barrier Breakdown in Neuroinflammation: Current In Vitro Models

Brandl,

Reindl

2023

IJMS

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The blood–brain barrier, which is formed by tightly interconnected microvascular endothelial cells, separates the brain from the peripheral circulation. Together with other central nervous system-resident cell types, including pericytes and astrocytes, the blood–brain barrier forms the neurovascular unit. Upon neuroinflammation, this barrier becomes leaky, allowing molecules and cells to enter the brain and to potentially harm the tissue of the central nervous system. Despite the significance of animal models in research, they may not always adequately reflect human pathophysiology. Therefore, human models are needed. This review will provide an overview of the blood–brain barrier in terms of both health and disease. It will describe all key elements of the in vitro models and will explore how different compositions can be utilized to effectively model a variety of neuroinflammatory conditions. Furthermore, it will explore the existing types of models that are used in basic research to study the respective pathologies thus far.

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Glia Connect Inflammation and Neurodegeneration in Multiple Sclerosis

Cited by 14 publications

References 146 publications

Modern possibilities of MRI-based diagnosis of multiple sclerosis. Literature review

Modern possibilities of MRI-based diagnosis of multiple sclerosis. Literature review

Modelling the innate immune system in microphysiological systems

Blood–Brain Barrier Breakdown in Neuroinflammation: Current In Vitro Models

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