Glenn circulation causes early and progressive shunting in a surgical model of pulmonary arteriovenous malformations
Tina Wan,
Henry Rousseau,
Carol Mattern
et al.
Abstract:Background: Pulmonary arteriovenous malformations (PAVMs) universally develop in patients with single ventricle congenital heart disease (CHD). Single ventricle PAVMs have been recognized for over 50 years, yet they are poorly understood, and we lack any medical therapies. To improve our understanding of single ventricle PAVM initiation and progression, we developed a surgical rat model of Glenn circulation and characterized PAVM physiology over multiple time points. Methods: Using adult rats, we performed a l… Show more
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