Gleason’s Grading of Carcinoma Prostate with PSA Correlation

Jose, Dr Lovely

doi:10.18535/jmscr/v5i9.44

Cited by 2 publications

(3 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Abu Farsakh and Abu Farsakh, observed no definite relationship between PSA and GS, [7] but we found similar results in cases with PSA value of <40 ng/ml. However, in cases of PSA above 40, an elevated serum PSA level is more likely to be correlating with higher grade of carcinoma, similar to study of Jose et al [6] We also noticed an interesting correlation of PSA level with GG2 and GG3, as majority of GG3 patients showed values above 20 and majority of GG2 patients were below 20.…”

Section: Discussionsupporting

confidence: 89%

“…Abu Farsakh and Abu Farsakh found 11% of PC patients with normal serum PSA whereas 6.8% of our patients belonged to this group. [7] The patients with PSA values between 0 and 4 ng/ml: 6.8%; 4-10 ng/ml: 13.6%; 10-20 ng/ml: 9%, and above 20 ng/ml: 70.4% were comparable with another study of Jose et al, where these were 3.6%, 13.3%, 16.6% and 66.5% respectively, [6] indicating around 80% patients show elevated PSA above 10 ng/ml. The histopathological Gleason grading system is a very significant prognostic factor used in risk stratification of PC patients while deciding management.…”

Section: Discussionsupporting

confidence: 76%

“…This goes well with another study where peak age incidence of PC was 7 th decade. [6] The intensity of raised PSA does not appear to be proportional to increasing age as older patients are distributed randomly in the PSA range of 20 to 100 ng/ml. Abu Farsakh and Abu Farsakh found 11% of PC patients with normal serum PSA whereas 6.8% of our patients belonged to this group.…”

Section: Discussionmentioning

confidence: 97%

See 2 more Smart Citations

Relation of Serum Prostate-Specific Antigen with Histological Features and Grading of Prostate Adenocarcinoma in Prostatic Biopsies

Fatima

Adiga

Haider

et al. 2020

Indian Journal of Medical and Paediatric Oncology

View full text Add to dashboard Cite

Introduction:The present study was undertaken on cases of prostate carcinoma and we tried to determine the relationship of elevated prostate specific antigen (PSA) level to histopathologic features associated with cancer in prostate biopsies and their relation to newest grade groups. Materials and Methods: The study was conducted in a tertiary health care center over a span of 3 years on patients with prostatic adenocarcinoma. The hematoxylin and eosin sections were reviewed as per World Health Organization 2016 new grading system and various other associated histopathological findings in the tissue noted. We tried to analyse correlation between serum PSA levels and histopathological features. Results: The majority of patients were in the age group of 70-80. Many patients (9/44) had the PSA in the range of 20-40 ng/ml and 10 patients (22.7%) had 80-100 ng/ml. There were three patients with normal PSA level and six patients with borderline level. Nine of 10 patients with marked increase in PSA level had higher grade groups. Histological subtyping showed 42 cases of acinar adenocarcinoma and 2 cases of ductal carcinoma. A number of associated findings were seen like benign prostatic hyperplasia (BPH): 13 cases, prostatitis: 28 cases, prostatic intraepithelial neoplasia: 7 cases -Low grade (1 case) and high grade (6 cases), and atrophy: 9 cases. Conclusions: We noticed majority of patients with grade group (GG) 3 and above had PSA value of more than 40 ng/ml, but PSA of <40 ng/ml did not correlate with the histologic grade groups. There was significant cut off value of PSA level 20 ng/ml between GG2 and GG3, differentiation of which is of clinical and histopathological significance. Histological subtyping showed acinar adenocarcinoma has no significant correlation with PSA levels however ductal carcinoma was associated with PSA levels <20 ng/ml. BPH association was seen to have PSA level of <40 ng/ml in majority of cases. The intensity of inflammation did not correlate with either degree of PSA level or histologic GG. We concluded serum PSA assay has prognostic application in the evaluation of patients undergoing prostate biopsies.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

Relation of Serum Prostate-Specific Antigen with Histological Features and Grading of Prostate Adenocarcinoma in Prostatic Biopsies

Fatima

Adiga

Haider

et al. 2020

Indian Journal of Medical and Paediatric Oncology

View full text Add to dashboard Cite

show abstract

Correlation between Total PSA Level and the Histoprognostic Gleason Score

Senghor,

Thiam,

Ndiaye

et al. 2024

OJPathology

View full text Add to dashboard Cite

Prostate cancer is a public health problem in Senegal. It is one of the most common cancers in men and can be detected early by PSA measurement and confirmed by the pathological study which specifies the histological type and evaluates the histoprognostic scores (Gleason and pTNM). We did not find any anatomopathological study highlighting a link between the PSA t rate and histoprognostic Gleason scores in Senegal. Objective: We carried out this work aimed at determining whether there is a correlation between the PSA t rate and the histoprognostic Gleason score, in our context. Methodology: This is a retrospective, descriptive and analytical study conducted from January 2013 to October 2021, based on histologically proven prostate cancer cases with a specified PSA level, diagnosed in the pathological anatomy and cytology laboratory of Aristide Le Dantec hospital. Results: We identified 654 cases of prostate cancer. The average age was 68.59 ± 5.8 years with extremes of 40 years to 92 years. More than half of our cohort presented a clinical stage T2c, i.e. 56.94%. The average prostate volume on ultrasound was 81.81 ± 66 cc. The median PSA t was 110.5 ng/ml, with extremes ranging from 2 ng/ml to 74,770 ng/ml. Prostatic adenocarcinoma was the only histological type found in our patients. There was a predominance of Gleason score 6 (PICU grade group 1) observed in 35.17% of patients. Well-differentiated cancers were predominant and represented 35.17%. There was a statistically significant positive correlation between PSA t level and Gleason score (Spearman's Rho = 0.305, p = 0.000). Conclusion: This study shows that in the Senegalese population, in patients with prostate cancer, the higher the PSA t level rises above normal, the higher the Gleason score tends to be.

show abstract

Gleason’s Grading of Carcinoma Prostate with PSA Correlation

Abstract: ABSTRACT

Cited by 2 publications

References 5 publications

Relation of Serum Prostate-Specific Antigen with Histological Features and Grading of Prostate Adenocarcinoma in Prostatic Biopsies

Relation of Serum Prostate-Specific Antigen with Histological Features and Grading of Prostate Adenocarcinoma in Prostatic Biopsies

Correlation between Total PSA Level and the Histoprognostic Gleason Score

Contact Info

Product

Resources

About