GLC of mycophenolic Acid and Related Compounds

Gainer, Frank E.; Wesselman, Harold J.

doi:10.1002/jps.2600590821

Cited by 11 publications

(1 citation statement)

References 11 publications

(7 reference statements)

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“…e different analytical methods that are reported for its determination include HPLC [1][2][3][4][5][6][7][8][9][10][11][12][13][14], LC/MS [15], HPTLC [16], spectrophotometry [17], and gas chromatography [18]. e aim of the present work is to develop and validate for the estimation of Mycophenolate in bulk and pharmaceutical formulations by derivative spectrophotometry [19] and to validate as per the ICH guidelines [20].…”

Section: Introductionmentioning

confidence: 99%

Validated Spectrophotometric Methods for the Determination of Mycophenolate: An Anti‐Neoplastic Agent in Bulk and Pharmaceutical Dosage Forms

Narendra

Deepika²,

Annapurna

2012

Journal of Chemistry

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ree simple, precise and cost-effective spectrophotometric methods have been developed for the determination of Mycophenolate in bulk and its pharmaceutical formulations. Mycophenolate shows max at 250.0 nm in zero-derivative spectrum (method A), 258.0 nm in �rst-derivative spectrum (method B) and method C is based on the calculation of area under curve (A�C) for analysis of Mycophenolate in the wavelength range of 240.0-260.0 nm. e drug follows the Beer-Lambert's law in the concentration range of 1.0-150.0 g/mL for all the methods. e methods were validated by following the analytical performance parameters suggested by the International Conference on Harmonization. All validation parameters were within the acceptable range. e developed methods were successfully applied to estimate the amount of Mycophenolate in bulk and pharmaceutical dosage forms.

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Section: Introductionmentioning

confidence: 99%

Validated Spectrophotometric Methods for the Determination of Mycophenolate: An Anti‐Neoplastic Agent in Bulk and Pharmaceutical Dosage Forms

Narendra

Deepika²,

Annapurna

2012

Journal of Chemistry

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Determination of Mycophenolic Acid and Its Glucuronide Metabolite in Plasma

Bopp

Schirmer

Meyers

1972

Journal of Pharmaceutical Sciences

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Biological Activities and Identification of Bioactive Metabolite from Endophytic Aspergillus flavus L7 Isolated from Aegle marmelos

Patil

Maheshwari

2015

Curr Microbiol

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Aegle marmelos, a well-known Indian plant with medicinal and religious importance, has been extensively used in Indian traditional medicine. The present study aimed to isolate, identify, and evaluate the biological activities of endophytic fungi from A. marmelos. One of the isolates, labeled as L7, was identified as Aspergillus flavus using morphology and ITS gene sequence. Total phenolic and flavonoid contents in the culture filtrate were found to be 65.77 mg GAE/ml and 158.33 mg quercetin/ml of crude extract, respectively. The extract showed excellent antimicrobial activity against common human bacterial and fungal pathogens. The test extract at 700 µg/ml, which notably reduced the concentration of DPPH-free radical as percent DPPH scavenging activity, was found to be the highest (64.53 %). The extract, at the concentration of 2 mg/ml, produced 70 % inhibition of hemolysis of RBCs compared to 78 % produced by standard drug (Ibuprofen). Chemical profiling of the fermented extract using TLC followed by UV and FTIR revealed the presence of flavonoids. The HPLC analysis confirmed the presence of bioflavonoid rutin in the extract. To the best of our knowledge, this is the first report on production of bioactive flavonoid by endophytic Aspergillus flavus obtained from A. marmelos and its pharmaceutical potential. In conclusion, the endophytic Aspergillus flavus obtained from the A. marmelos could be explored as an economic and potential natural resource with diverse pharmaceutical and biological activities.

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GLC of mycophenolic Acid and Related Compounds

Cited by 11 publications

References 11 publications

Validated Spectrophotometric Methods for the Determination of Mycophenolate: An Anti‐Neoplastic Agent in Bulk and Pharmaceutical Dosage Forms

Validated Spectrophotometric Methods for the Determination of Mycophenolate: An Anti‐Neoplastic Agent in Bulk and Pharmaceutical Dosage Forms

Determination of Mycophenolic Acid and Its Glucuronide Metabolite in Plasma

Biological Activities and Identification of Bioactive Metabolite from Endophytic Aspergillus flavus L7 Isolated from Aegle marmelos

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