GLC Determination of Meperidine in Blood Plasma

Meperidine and Other Basic Drugs: General Method for Their Determination in Plasma

“…A common triangular feature among certain antimalarial cinchona alkaloids, aminoalcohols, and 2-(p-chlorophenyl)-2-(4-piperidyl)tetrahydrofuran was recently proposed from this laboratory (1). The components as well as parameters involved in this pharmacophore are interestingly similar to those proposed for a-adrenergic receptor features ( 2 ) .…”

Clinical Pharmacokinetics Pethidine

“…In contrast, many gas liquid chromatographic techniques using flame ionisation detection have been described over the past 5 years (e.g. Goehl and Davison, 1973;Chan et al, 1974;Klotz et al, 1974;Mather and Tucker, 1974;Stambaugh and Wainer, 1974;Shih et aI., 1976;Evans and Harbison, 1977). A significant improvement in the sensitivity and selectivity may be gained through a nitrogen sensitive flame ionisation detector.…”

High Pressure Liquid Chromatographic Determination of Pethidine in Plasma

“…Procedures available for the analysis of pethidine in plasma include the colourimetric technique of Burns et al (1955), fluorimetric assay (Dal Cortivo et al, 1970) and the gas chromatographic (GC) methods (Beckett & Tayler, 1967;Goehl & Davison, 1973;Knowles e f al., 1973;Szeto & Inturrisi, 1976). Many of these procedures are associated with problems of one kmd or another.…”

“…Either they are complex, lengthy, nonspecific or lack internal standard techniques. Goehl & Davison (1973) have presented a brief account of these methods and their limitations. Most GC procedures, though sensitive, are complicated due to the derivatization reactions.…”