Glaucome cortisonique : étude épidémiologique, clinique et thérapeutique

Afrit, M.A. El; Mazlout, H.; Trojet, S.; Larguech, L.; Megaieth, K.; Belhaj, S.; Khémiri, N.; Kraiem, A.

doi:10.1016/s0181-5512(07)89550-7

Cited by 10 publications

(3 citation statements)

References 5 publications

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“…Present pharmacological treatment for uveitis primarily includes corticosteroids and non-steroidal anti-inflammatory drugs. However, these drugs do not completely control the disease in many patients and, with long-term application, they may result in many adverse effects such as cataract, glaucoma, susceptibility to microbial infection and nephrotoxicity (McGhee et al, 2002;Nguyen et al, 2006;El Afrit et al, 2007). Hence, there is a need for therapeutic agents with safer modes of action.…”

Section: Introductionmentioning

confidence: 99%

Treatment with melatonin after onset of experimental uveitis attenuates ocular inflammation

Sande

Dorfman

Fernandez

et al. 2014

British J Pharmacology

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BACKGROUND AND PURPOSEUveitis is a prevalent intraocular inflammatory disease and one of the most damaging ocular conditions. Pretreatment with melatonin prevented ocular inflammation induced by an intravitreal injection of bacterial LPS in the Syrian hamster. Here, we have assessed the anti-inflammatory effects of melatonin administered after the onset of ocular inflammation. EXPERIMENTAL APPROACHThe eyes of male Syrian hamsters were intravitreally injected with vehicle or LPS. Melatonin was injected i.p. every 24 h, starting 12 or 24 h after the LPS injection. A clinical evaluation (with a score index based on clinical symptoms), the number of infiltrating cells, protein concentration and PGE2 and PGF2α levels in the aqueous humour, as well as retinal NOS activity, lipid peroxidation and TNF-α levels were assessed. Retinal function was assessed by scotopic electroretinography, and light microscopy and immunohistochemistry were used to evaluate the state of the retinal structure. KEY RESULTSBoth treatment regimens with melatonin decreased clinical symptoms, reduced the leakage of cells and proteins, and decreased PG levels in aqueous humour from eyes injected with LPS. In addition, melatonin treatment blocked the decrease in scotopic electroretinogram a-and b-wave amplitude, protected the retinal structure and reduced the increase in NOS activity, lipid peroxidation and TNF-α levels, induced by LPS. CONCLUSIONS AND IMPLICATIONSThese results indicate that treatment with melatonin, starting after the onset of uveitis, attenuated ocular inflammation induced by LPS in the Syrian hamster and support the use of melatonin as a therapeutic resource for uveitis treatment. AbbreviationsBOB, blood-ocular barrier; EIU, endotoxin-induced uveitis; ERG, electroretinogram; GFAP, glial fibrillary acidic protein; MDA, malondialdehyde bis-dimethyl acetal; TBARS, thiobarbituric acid reactive substances BJP British Journal of Pharmacology

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Section: Introductionmentioning

confidence: 99%

Treatment with melatonin after onset of experimental uveitis attenuates ocular inflammation

Sande

Dorfman

Fernandez

et al. 2014

British J Pharmacology

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“…Les caractéristiques cliniques du glaucome cortisonique sont similaires au GPAO, à l'exception d'antécédents de corticothérapie dans le premier cas. Le délai de réponse hypertensive est en corrélation particulièrement avec la durée et l'intensité de la corticothérapie [4,5].…”

Section: Discussionunclassified

Problématique Du Traitement De La Limbo-Conjonctivite Endémique Des Tropiques (Lcet)

Diane.¹

2022

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Corticosteroid is an iatrogenic secondary open-angle glaucoma induced by corticosteroids administered locally or systematically for chronic condition, most often inflammatory. It clinically resembles primary open -angle glaucoma (POAG), characterized by a progressive inrease in ocular pressure secondary to increased resistance to aqueous humor out flow, papillary cupping, and visual field alterations. It is estimated that about 30 to 40% of the general population would be likely to present with ocular hypertension lied to the intake of corticosteroids , but that this proportion increases to 90%in a population of individuals also presenting with primary open-angle glaucoma.The best treatment at the present remains prevention, ensuring adequate monitoring with any local or systemic corticosteroid therapy. We report the case of cortisonic glaucoma in children about a case. The purpose of our work is to present a bilateral case that is already very advanced during the initial treatment and to clarify the issue.

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“…La pathogénie du glaucome induite par les corticoïdes est encore mal connue. L'augmentation de la résistance trabécu-laire par différents mécanismes, notamment par une accumulation de mucopolysaccharides au niveau du trabéculum, et une modification de taille et d'adhésion cellulaire, semble déter-minante [18,19]. La durée d'exposition aux corticoïdes et la dose palier sont deux facteurs de risques encore débattus.…”

Section: Glaucome Cortisoniqueunclassified