Glaucoma With the Oculocerebrorenal Syndrome of Lowe

Abstract

A primary X-linked infantile glaucoma is a defining and frequent component of OCRL and is secondary to expression of a primary filtration angle anomaly. Goniotomy was unsuccessful in all (8) operated eyes. The adverse effects of cataract surgery on the filtration angle structures may influence the results of goniotomy surgery by superimposing a secondary aphakic glaucoma component that may explain the need for alternative glaucoma surgery.

Inherited cerebrorenal syndromes

“…Biopsies performed past the age of 10 years show interstitial disease of increased severity with secondary glomerulo sclerosis. 6,15 the mechanism of renal failure is not known. norden and colleagues 17 observed that in lowe and similar tubulo pathies, the lowmolecularweight proteins excreted in excess include chemokines and other bioactive proteins, and have speculated that these proteins contribute to interstitial inflammation and fibrosis.…”

“…5 although goniotomy would be expected to lead to improvement in these patients, such improvements seldom occur, and increased intraocular pressure is rarely relieved by surgical intervention. 6 loss of vision progresses, often to blindness. thus, although glaucoma screening every reviews severe to profound handicap and only about 10% in the range of low to normal intellectual function.…”

Multiple Epidermal Cysts in Lowe Syndrome

“…At birth, congenital cataract is the most common finding, with other ocular diseases such as glaucoma, corneal cheloid, corneal opacity, nystagmus, and amblyopia also seen 3,8,9 . In the nervous system, neonatal hypotonia and loss or decrease of deep tendon reflexes are frequent initial symptoms with motor development retardation, mental retardation, seizures and growth and development delays also reported 1,10 .…”

Developmental and childhood glaucoma

“…Possibly the early surgical removal of cataract introduces the complexities of aphakic open-angle glaucoma into the clinical picture. 285 This syndrome must be distinguished from the Zellweger (hepatocerebrorenal) syndrome, a lethal peroxisomal biogenesis disorder that causes infantile hypotonia, seizures, and death within the first year. Ophthalmic manifestations include corneal opacification, cataract, glaucoma, pigmentary retinopathy, and optic atrophy.…”