Glaucoma in penetrating keratoplasty: risk factors, management and outcome

Huber, K. K.; Maier, Anna-Karina B.; Klamann, Matthias K. J.; Rottler, Jessica; Özlügedik, Sevil; Rosenbaum, Katja; Gonnermann, Johannes; Winterhalter, Sibylle; Joussen, Antonia M.

doi:10.1007/s00417-012-2065-x

Cited by 57 publications

(65 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The prevalence of traumatic IOP elevation and glaucoma after PKP is known to be elevated, ranging between 11 and 48%, [20][21][22][23][24] and is perhaps particularly elevated in eyes after penetrating eye injury. 25 Mechanisms for IOP elevation after PKP include postoperative edema and inflammation compromising the trabecular meshwork, angle scarring, peripheral anterior synechiae, retained viscoelastics, and steroid response.…”

Section: Discussionmentioning

confidence: 99%

Incidence and risk factors for traumatic intraocular pressure elevation and traumatic glaucoma after open-globe injury

Bojikian

Stein

Slabaugh

et al. 2015

Eye

View full text Add to dashboard Cite

Purpose To examine traumatic intraocular pressure (IOP) elevation and glaucoma after open-globe injury. Design Retrospective, observational case series. Methods Review of patients with open-globe repair at the University of Washington from May 1997 through July 2010. Traumatic IOP elevation and glaucoma were defined respectively as intraocular pressure (IOP) ≥ 22 mm Hg at 41 visit or need for glaucoma medication, and long-term (at least 3 months) glaucoma medication use or glaucoma surgery. Results We included 515 eyes (515 patients). The mean follow-up was 12.6 ± 20.1 months. One hundred twenty eyes (23.3%) developed traumatic IOP elevation, of which 32 (6.2%) developed glaucoma; six eyes (1.2%) required glaucoma surgery. The mean time to development of traumatic IOP elevation was 1.5 ± 3.4 months (range 1 day to 2 years). Kaplan-Meier 6-and 12-month estimates for development of traumatic IOP elevation were 27.2 and 32.4%, respectively, and for development of traumatic glaucoma were 7.1 and 11.0%, respectively. Multivariate regression revealed associations between traumatic IOP elevation and older age, and traumatic glaucoma and prior penetrating keratoplasty, initial vitreous hemorrhage, Zone II injury, and penetrating keratoplasty after open-globe repair. Traumatic glaucoma was controlled (IOP o22 mm Hg) in 78.1% of eyes at final follow-up, with mean IOP of 18.2 mm Hg on 1.7 medications. Conclusions Traumatic IOP elevation and glaucoma were common after visually salvageable open-globe injury. Most cases developed within 6 months, although longer follow-up remains important for case detection. Penetrating keratoplasty before or after repair, and vitreous hemorrhage were notable risk factors.

show abstract

Section: Discussionmentioning

confidence: 99%

Incidence and risk factors for traumatic intraocular pressure elevation and traumatic glaucoma after open-globe injury

Bojikian

Stein

Slabaugh

et al. 2015

Eye

View full text Add to dashboard Cite

show abstract

“…The incidence of ITC (11-29%) was less than in other studies after PK (56%, 96.8%) [16,21,22], but in these studies not only cases of FED and BK were analysed. Nonetheless, our data showed that PAS in cases of FED are significantly associated with the development of post-keratoplasty glaucoma, not only in eyes after PK but also in eyes after DSEK (p = 0.01) [7,17,18,19,20,21].…”

Section: Discussionmentioning

confidence: 85%

“…- Post-keratoplasty glaucoma, iatrogenic-induced secondary glaucoma, was defined as a durable elevated IOP ≥22 mm Hg at different time points that resulted in the introduction of anti-glaucoma medication or surgical intervention [14,16,17]. In patients with pre-existing glaucoma, worsening of the IOP control requiring additional medication or surgery was necessary for the diagnosis of post-keratoplasty glaucoma [14,16].…”

Section: Methodsmentioning

confidence: 99%

“…In patients with pre-existing glaucoma, worsening of the IOP control requiring additional medication or surgery was necessary for the diagnosis of post-keratoplasty glaucoma [14,16]. The definition was independent of associated visual field loss and optic nerve head changes.…”

Section: Methodsmentioning

confidence: 99%

“…Multiple studies found a high correlation between PAS and IOP elevation after PK and post-PK glaucoma [7,16,17,18,19,20,21,22]. After DSEK, steroid-related ocular IOP elevation was identified as a major cause [1,13].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Anterior Segment Analysis and Intraocular Pressure Elevation after Penetrating Keratoplasty and Posterior Lamellar Endothelial Keratoplasty

et al. 2014

Self Cite

View full text Add to dashboard Cite

Background: Peripheral anterior synechiae (PAS) is a common problem after penetrating keratoplasty (PK) and leads to intraocular pressure (IOP) elevation. This study examines the risk factors for IOP elevation and post-keratoplasty glaucoma. Methods: A retrospective analysis was performed of 47 eyes following PK and of 65 eyes following Descemet's stripping endothelial keratoplasty (DSEK) between 2009 and 2011. The assessment included preoperative history of corneal disease and glaucoma, response to treatment, IOP, and visual acuity. Irido-trabecular contacts (ITC), the angle opening distance (AOD 500) and the anterior chamber angle (ACA 500) were calculated. Results: The incidences of IOP elevation and post-keratoplasty glaucoma were 27-36% and 10-29%, respectively. The incidence did not differ significantly between both procedures. Pre-existing glaucoma increased the risk for developing IOP elevation and post-DSEK glaucoma. Eyes with bullous keratopathy (BK) developed significantly more IOP elevation (p = 0.01, d.f. = 1, χ² = 6.11) and post-keratoplasty glaucoma (p = 0.01, d.f. = 1, χ² = 6.22) than eyes with Fuchs' endothelial dystrophy. Eyes with ITC developed post-keratoplasty glaucoma significantly more often than eyes without ITC (p = 0.01, d.f. = 1, χ² = 6.63). Conclusion: IOP elevation and post-keratoplasty glaucoma showed a high incidence. Risk factors like pre-existing glaucoma, BK and PAS elevated the rate of IOP elevation and post-keratoplasty glaucoma for both procedures. © 2014 S. Karger AG, Basel

show abstract

Keratoplasty and Glaucoma

Stein

McDonnell

et al. 2022

Albert and Jakobiec's Principles and Practice of Ophthalmology

View full text Add to dashboard Cite

Glaucoma in penetrating keratoplasty: risk factors, management and outcome

Cited by 57 publications

References 44 publications

Incidence and risk factors for traumatic intraocular pressure elevation and traumatic glaucoma after open-globe injury

Incidence and risk factors for traumatic intraocular pressure elevation and traumatic glaucoma after open-globe injury

Anterior Segment Analysis and Intraocular Pressure Elevation after Penetrating Keratoplasty and Posterior Lamellar Endothelial Keratoplasty

Keratoplasty and Glaucoma

Contact Info

Product

Resources

About