Glaucoma in high myopia and parapapillary delta zone

Jonas, Jost B; Weber, Pascal; Nagaoka, Natsuko; Ohno‐Matsui, Kyoko

doi:10.1371/journal.pone.0175120

Cited by 60 publications

(58 citation statements)

References 24 publications

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“…After adjusting for age, IOP, and AL, their study revealed a significantly smaller radius and greater DA in severe glaucoma which were similar to the corneal deformation responses found in the HM group in our study. Our findings suggest that HM and glaucoma may share some common ocular biomechanical behavior and thus can support the epidemiological findings that show higher prevalence of glaucoma in patients with HM [45,46]. Given that the sclera, cornea, and lamina cribrosa are connected and primarily composed of similar extracellular matrix, corneal biomechanical parameters can be regarded as global properties of the eye [10].…”

Section: Discussionsupporting

confidence: 83%

Comparison of Corneal Biomechanical Properties among Axial Myopic, Nonaxial Myopic, and Nonmyopic Eyes

Tubtimthong

Chansangpetch

Ratprasatporn

et al. 2020

BioMed Research International

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Purpose. To compare corneal deformation characteristics using ultra-high-speed Scheimpflug camera (Corvis ST) in patients with nonmyopic (NM), mild-to-moderate nonaxial myopic (MM), and high axial myopic (HM) eyes. Methods. In this cross-sectional study, normal subjects aged >40 years with no history of ocular laser/surgery were classified according to axial length (AL) and spherical equivalence (SE) into three groups: (1) NM (SE > −0.50 D and AL < 26 mm), (2) MM (SE −6.00 D to −0.50 D and AL < 26 mm), and (3) HM (SE ≤ −6.00 D and AL ≥ 26 mm). Seven parameters including corneal deformation amplitude (CDA), inward/outward corneal applanation length, inward/outward corneal velocity (ICV and OCV), peak distance, and radius were measured. Pearson correlation and linear mixed-effects model were done. Results. A total of 180 eyes were recruited. 98 eyes were NM, 30 eyes were MM, and 52 eyes were HM. There were significant correlations of OCV to the degree of refractive error (r = 0.203, p<0.001) and AL (r = −0.242, p<0.001). After adjusting for age, sex, intraocular pressure, and corneal thickness, there was significantly higher CDA (β = 0.07, p<0.001), faster OCV (β = −0.08, p<0.001), and smaller radius (β = −0.39, p=0.01) in the HM group compared to the NM group. Conclusion. The higher CDA, faster OCV, and smaller radius found in the HM may suggest that these eyes have reduced ocular stiffness and may be less stable and more prone to stress.

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Section: Discussionsupporting

confidence: 83%

Comparison of Corneal Biomechanical Properties among Axial Myopic, Nonaxial Myopic, and Nonmyopic Eyes

Tubtimthong

Chansangpetch

Ratprasatporn

et al. 2020

BioMed Research International

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“…Myopic maculopathy and optic nerve atrophy in association with high axial myopia have become some of the most common causes of irreversible vision impairment and blindness 48‐50 . The most important risk factor for the development and progression of myopic maculopathy and highly myopic optic nerve damage is a long axial length and further elongation 51‐53 . If EGF and its family members are involved in the process of axial elongation and if the intraocular application of EGF (family) antibodies reduces further ocular elongation, progression of myopic maculopathy and optic nerve damage may be halted by the intraocular injection of these antibodies.…”

Section: Discussionmentioning

confidence: 99%

Blockade of epidermal growth factor and its receptor and axial elongation in experimental myopia

Dong

et al. 2020

FASEB j.

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To examine the influence of epidermal growth factor (EGF) and its receptor (EGFR) on axial ocular elongation, we intraocularly injected an EGF antibody and an EGFR antibody into young guinea pigs with lens‐induced axial elongation (myopization). Mean axial elongation was reduced in the eyes injected with the EGF/EGFR‐antibody compared with the contralateral control eyes injected with PBS (phosphate‐buffered solution) (0.43 ± 0.13 mm vs 0.53 ± 0.13 mm; P < .001). The intereye difference in axial length increased (P = .005) as the doses of the EGF antibody and EGFR antibody increased. As a corollary, the thickness of the retina at the posterior pole was dose‐dependently increased in the injected eyes compared to the contralateral control eyes. Immunohistochemical staining for EGF and the relative mRNA expression of EGF and EGFR were the highest in eyes not injected with the EGF antibody or EGFR antibody and decreased (P < .05) as the dose of EGF antibody or EGFR antibody increased. In an in vitro study, EGF had a stimulating effect and the EGF antibody had an inhibitory effect on the proliferation and migration of RPE cells. The findings showed that the intravitreal application of an EGF antibody and EGFR antibody is associated with a dose‐dependent reduction in lens‐induced axial elongation in young guinea pigs. The EGFR family may play a role in axial elongation of the eye and in the development of myopia.

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“…Myopia is a common yet insidious condition, with each dioptre increasing the burden associated with the condition. Particularly, high myopia (≤−5.00D) increases the risk of vision impairment due to complications such as myopic macular degeneration, chorio‐retinal atrophy and glaucoma . Given the substantially high prevalence of myopia in many East Asian countries and rising prevalence elsewhere, its impact on eye health and the associated economic burden is significant …”

Section: Introductionmentioning

confidence: 99%

Myopia control with novel central and peripheral plus contact lenses and extended depth of focus contact lenses: 2 year results from a randomised clinical trial

Sankaridurg

Bakaraju

Naduvilath

et al. 2019

Ophthalmic Physiologic Optic

116

155

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PurposeWe aimed to determine myopia control efficacy with novel contact lenses (CL) that (1) reduced both central and peripheral defocus, and (2) provided extended depth of focus with better global retinal image quality for points on, and anterior to, the retina and degraded for points posterior to the retina.MethodsChildren (n = 508, 8–13 years) with cycloplegic spherical equivalent (SE) −0.75 to −3.50D were enrolled in a prospective, double blind trial and randomised to one of five groups: (1) single vision, silicone hydrogel (SH) CL; (2) two groups wearing SH CL that imposed myopic defocus across peripheral and central retina (test CL I and II; +1.00D centrally and +2.50 and +1.50 for CL I and II at 3 mm semi‐chord respectively); and (3) two groups wearing extended depth of focus (EDOF) hydrogel CL incorporating higher order aberrations to modulate retinal image quality (test CL III and IV; extended depth of focus of up to +1.75D and +2.50D respectively). Cycloplegic autorefraction and axial length (AL) measurements were conducted at six monthly intervals. Compliance to lens wear was assessed with a diary and collected at each visit. Additionally, subjective responses to various aspects of lens wear were assessed. The trial commenced in February 2014 and was terminated in January 2017 due to site closure. Myopia progression over time between groups was compared using linear mixed models and where needed post hoc analysis with Bonferroni corrections conducted.ResultsMyopia progressed with control CL −1.12 ± 0.51D/0.58 ± 0.27 mm for SE/AL at 24 months. In comparison, all test CL had reduced progression with SE/AL ranging from −0.78D to −0.87D/0.41–0.46 mm at 24 months (AL: p < 0.05 for all test CL; SE p < 0.05 for test CL III and IV) and represented a reduction in axial length elongation of about 22% to 32% and reduction in spherical equivalent of 24% to 32%. With test CL, a greater slowing ranging from 26% to 43% was observed in compliant wearers (≥6 days per week; Control CL: −0.64D/0.30 mm and −1.14D/0.58 mm vs test CL: −0.42D to −0.47D/0.12–0.18 mm and −0.70 to −0.81D/0.19–0.25 mm at 12 and 24 months respectively).ConclusionsContact lenses that either imposed myopic defocus at the retina or modulated retinal image quality resulted in a slower progression of myopia with greater efficacy seen in compliant wearers. Importantly, there was no difference in the myopia control provided by either of these strategies.

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Glaucoma in high myopia and parapapillary delta zone

Cited by 60 publications

References 24 publications

Comparison of Corneal Biomechanical Properties among Axial Myopic, Nonaxial Myopic, and Nonmyopic Eyes

Comparison of Corneal Biomechanical Properties among Axial Myopic, Nonaxial Myopic, and Nonmyopic Eyes

Blockade of epidermal growth factor and its receptor and axial elongation in experimental myopia

Myopia control with novel central and peripheral plus contact lenses and extended depth of focus contact lenses: 2 year results from a randomised clinical trial

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