Glaucoma: Current treatment and impact of advanced drug delivery systems

Yadav, Khushwant S.; Rajpurohit, Rahul; Sharma, Sushmita

doi:10.1016/j.lfs.2019.02.029

Cited by 141 publications

(105 citation statements)

References 100 publications

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“…In a recent article written by Yadav et al (2019), it was highlighted how pre-corneal factors lead to the low absorption of ocular active ingredients used to treat glaucoma, administered as eye drops. These factors, such as tear turnover rate and the drainage of the formulation from the administration site, result in a 70-80% loss of the amount of drug which is administered.…”

Section: Current Commercial Formulations Utilized For the Delivery Ofmentioning

confidence: 99%

See 1 more Smart Citation

Hydrogel Biomaterials for Application in Ocular Drug Delivery

Lynch

Kondiah

Choonara

et al. 2020

Front. Bioeng. Biotechnol.

148

103

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Section: Current Commercial Formulations Utilized For the Delivery Ofmentioning

confidence: 99%

“…The consideration of ointments has been made, as these formulations have a higher viscosity and are not as rapidly drained from the eye as a liquid formulation. However, ointments are known to cause blurred vision when administered which leads to poor patient compliance (Yadav et al, 2019).…”

Section: Current Commercial Formulations Utilized For the Delivery Ofmentioning

confidence: 99%

Hydrogel Biomaterials for Application in Ocular Drug Delivery

Lynch

Kondiah

Choonara

et al. 2020

Front. Bioeng. Biotechnol.

148

103

View full text Add to dashboard Cite

“…Although the various dynamic and static barriers of the eye helps to prevent the invasion of pathogens, these protective barriers can lead to the low systemic bioavailability of useful drugs for the injured or diseased eye (2). This leads to the more frequent use of drugs with a low therapeutic index, which ultimately causes the deposition of concentrated solutions on the surface and inside of the eye, resulting in the production of toxic effects and damage to the ocular cells and tissues (3). To overcome these problems, nano-scaled drug delivery systems have been rapidly developed.…”

Section: Introductionmentioning

confidence: 99%

Are PAMAM dendrimers safe for ocular applications? -- Toxicological evaluation in ocular cells and intraocular tissues

Chen

Tang

Wen

et al. 2020

Preprint

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Backgrounds: The human eye is a sophisticated and sensitive sensory organ. Due to its dynamic and static barriers, efficient drug therapy for eye diseases is problematic. Polymeric delivery systems have been rapidly developed to overcome this problem, where polymeric dendrimers have received much attention for their unique structures. However, there is insufficient research on whether dendrimer nanomaterials could be used in ophthalmology. Poly (amidoamine) (PAMAM) is a kind of commercialized and extensively used dendrimer. Herein the ocular cytotoxicity and biosafety of PAMAM dendrimers were deeply evaluated by conducting in vitro and in vivo experiments on ocular systems. The effects of generation (G4.0, G5.0, and G6.0) and concentration on cell metabolism, apoptosis, and oxidative damage were carried out. Ocular irritation and intravitreal injection effects were also measured. Results: The results showed that the cytotoxicity of PAMAM increased with increasing generation number. PAMAM at a concentration that below 50 μg/mL was less harmful to the ocular tissues, whereas it caused apparent damage when above 50 μg/mL in the investigated situation. Moreover, singlet oxygen generation was detected in the cells after 50 μg/mL (and above) PAMAM treatment. The in vivo results show that there is no macroscopic structural change observed from fundus and histopathological section images, whereas it shows more functional impairment according to optical coherence tomography (OCT) and electroretinogram (ERG) when treated by 100 μg/mL PAMAM. Conclusion: Overall, a higher concentration of PAMAM, such as above 50 μg/mL, may cause ocular functional damage. The concentrations that are (or lower than) 50 μg/mL showed good biocompatibility and biosafety in human ocular cells and tissues.

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“…At low stress, it is likely that the elastin component allows for an initially large volume change formed by the distending ONH and, as pressure increases and the extended collagen fibers limit further deformation, the ONH becomes progressively stiffer. 6 Elevated intraocular pressure (IOP) is the most important risk factor for glaucoma progression, 7 which distorts the tissues of the ONH, and LC within, triggering events, such as compromised axoplasmic flow, vascular perfusion, and astrocyte activation that eventually lead to optic nerve axon degeneration and RGC death. 7,8 An improved understanding of the ONH biomechanical environment and of the dependence of this environment on the biomechanical properties of the ONH tissues is necessary to understand better how biomechanical effects may play a role in glaucomatous optic neuropathy.…”

Section: Introductionmentioning

confidence: 99%

“…6 Elevated intraocular pressure (IOP) is the most important risk factor for glaucoma progression, 7 which distorts the tissues of the ONH, and LC within, triggering events, such as compromised axoplasmic flow, vascular perfusion, and astrocyte activation that eventually lead to optic nerve axon degeneration and RGC death. 7,8 An improved understanding of the ONH biomechanical environment and of the dependence of this environment on the biomechanical properties of the ONH tissues is necessary to understand better how biomechanical effects may play a role in glaucomatous optic neuropathy. 9 There are several experimental techniques currently being used to investigate changes in the mechanical compliance of the ONH and posterior scleral surface.…”

Section: Introductionmentioning

confidence: 99%

Quantitative confocal optical coherence elastography for evaluating biomechanics of optic nerve head using Lamb wave model

Qian

et al. 2019

Neurophoton.

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The mechanosensitivity of the optic nerve head (ONH) plays a pivotal role in the pathogenesis of glaucoma. Characterizing elasticity of the ONH over changing physiological pressure may provide a better understanding of how changes in intraocular pressure (IOP) lead to changes in the mechanical environment of the ONH. Optical coherence elastography (OCE) is an emerging technique that can detect tissue biomechanics noninvasively with both high temporal and spatial resolution compared with conventional ultrasonic elastography. We describe a confocal OCE system in measuring ONH elasticity in vitro, utilizing a pressure inflation setup in which IOP is controlled precisely. We further utilize the Lamb wave model to fit the phase dispersion curve during data postprocessing. We present a reconstruction of Young's modulus of the ONH by combining our OCE system with a Lamb wave model for the first time. This approach enables the quantification of Young's modulus of the ONH, which can be fit using a piecewise polynomial to the corresponding IOP.

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Glaucoma: Current treatment and impact of advanced drug delivery systems

Cited by 141 publications

References 100 publications

Hydrogel Biomaterials for Application in Ocular Drug Delivery

Hydrogel Biomaterials for Application in Ocular Drug Delivery

Are PAMAM dendrimers safe for ocular applications? -- Toxicological evaluation in ocular cells and intraocular tissues

Quantitative confocal optical coherence elastography for evaluating biomechanics of optic nerve head using Lamb wave model

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