Glassy Polymersomes: Polymersomes: Breaking the Glass Ceiling? (Small 46/2018)

Chidanguro, Tamuka; Ghimire, Elina; Liu, Cheyenne H.; Simon, Yoan C.

doi:10.1002/smll.201870216

Cited by 1 publication

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“…Advances in precise block copolymer synthesis (i.e., molecular weight control, end-group fidelity, monomer selection) have led to tailorable interfacial curvature and block copolymer asymmetry that generate predictable morphologies and nanostructure organization. 13 For a given amphiphilic block copolymer system, adjustments in block volume fraction and nature (i.e., glassy 14,15 vs. soft) can generate a plethora of morphologies in dilute aqueous environments-including spherical or cylindrical micelles, 16,17 network phase and bilayers/vesicles. 18 The introduction of stimuli-responsive motifs to these self-assembled systems, such as photoresponsive functional groups (i.e., azobenzene, 19,20 o-nitrobenzene, 21 ) temperature-responsive blocks (i.e., poly(N-isopropylacrylamides), 22,23 or even so-called rigid-flexible blocks, 24 grant access to incredibly versatile and responsive nanoobjects.…”

Section: Introductionmentioning

confidence: 99%

Self‐assembly and degradation of photolabile diblock bottlebrushes

Liu,

Dugas,

Dishner

et al. 2024

Journal of Polymer Science

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Aqueous self‐assembly of amphiphilic block copolymers form diverse nanostructured morphologies depending on block volume fraction and solvophilicity. Stimuli‐responsive motifs have been combined with self‐assembled micelles to afford spatiotemporal, on‐demand encapsulation and payload release. However, the role of modular polymer architecture (i.e., bottlebrushes) in stimuli‐responsive aqueous self‐assembly is not fully understood. The synthesis, aqueous self‐assembly, and photoirradiation of photolabile, amphiphilic bottlebrush block copolymers is presented herein. Specifically, the efficient photoscission of o‐nitrobenzene motifs at the junction of a poly(norbornene o‐nitrobenzene polystyrene)‐block‐poly(norbornene polyethylene glycol) diblock bottlebrush side chain and backbone cleaved away hydrophobic polystyrene side chains and artificially increased the volume fraction of poly(ethylene glycol) (fPEG). In doing so, self‐assembled micelles readily degrade to micelle‐to‐micelle and micelle‐to‐aggregate structures after photoirradiation. Finally, this bottlebrush micelle system is used to demonstrate the efficient encapsulation and stimuli‐responsive release of Nile Red that is monitored by fluorescence spectroscopy and dynamic light scattering. The contribution of this work expands the utility of amphiphilic bottlebrush systems as highly efficient and responsive, hierarchically assembled nanomaterials.

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