Glassy cell carcinoma of the endometrium responsive to megestrol acetate

Dawson, Erin; Belinson, Jerome L.; Lee, Kenneth

doi:10.1016/0090-8258(89)90616-1

Cited by 8 publications

(5 citation statements)

References 5 publications

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“…Whereas cases arised in the endometrium occur mainly in postmenouposal period. Dawson et al published the oldest case, a 96-year-old endometrial GCC case 7 and our patient is the second oldest one after that.…”

Section: Case Reportsupporting

confidence: 49%

Primary adenosquamous carcinoma of the endometrium with glassy cell features. A diagnostic pitfall as a very rare tumour type in the endometrium

et al. 2022

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Summary Primary adenosquamous carcinoma of the endometrium with glassy cell features (ASCGCF) is an extremely rare entity and to date, 16 cases of this entity have been reported in the literature. ASC-GCF is an aggressive histological subtype of cervical carcinoma with rapid growth and early metastases; however, very little is known about those originating from the endometrium as they are limited to only a few case reports. Herein, we report a case of primary adenosquamous carcinoma of the endometrium with extensive glassy cell features which posed a major diagnostic challenge by mimicking many entities with its histological diversity.

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Section: Case Reportsupporting

confidence: 49%

Primary adenosquamous carcinoma of the endometrium with glassy cell features. A diagnostic pitfall as a very rare tumour type in the endometrium

et al. 2022

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“…Another important feature of this malignancy is that, other than stage, there are no apparent pathologic or molecular factors that are consistent prognostic variables in predicting treatment response. One isolated case report [8] described a complete response to a synthetic progestin with antiestrogenic properties in a patient with lung metastasis. This is indirect evidence of the presence of progesterone receptors, which could have been helpful in our case, considering the positive hormonal receptors.…”

Section: Discussionmentioning

confidence: 99%

Glassy Cell Carcinoma of the Endometrium Presenting as an Intracavitary Leiomyoma on Ultrasound

Fox

Schimp

et al. 2019

Am J Case Rep

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Patient: Female, 58 Final Diagnosis: Endometrial poorly differentiated adenosquamous carcinoma • glassy cell carcinoma tumor Symptoms: Postmenopausal spotting Medication: — Clinical Procedure: Endometrial biopsy then robotic total hysterectomy • bilateral salpingooophrectomy • pelvic lymph node mapping and bilateral pelvic lymphadenectomy Specialty: Obstetrics and Gynecology Objective: Rare co-existance of disease or pathology Background: Glassy cell carcinoma of the endometrium is an extremely rare variant of adenosquamous carcinoma, and it has a poor prognosis. In postmenopausal women it typically presents as unprovoked, painless uterine bleeding. Tissue sampling is necessary to establish the diagnosis. Case Report: A 58-year-old postmenopausal woman on no hormone replacement therapy experienced 2 months of intermittent uterine bleeding. An office transvaginal ultrasound discovered a 1.7-cm intracavitary leiomyoma, but because the endometrial stripe was not visualized, an endometrial biopsy was performed. She was found to have a Stage 1 A endometrial poorly-differentiated adenosquamous carcinoma, glassy cell carcinoma tumor of 1.5 cm in greatest dimension. She underwent a robotic total hysterectomy, bilateral salpingo-oophorectomy, pelvic lymph node mapping, and bilateral pelvic lymphadenectomy. Conclusions: Glassy cell carcinoma of the endometrium can present as an intracavitary leiomyoma in postmenopausal women.

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“…The treatment was radiation followed by hysterectomy in 3 cases; radiation alone in 2 cases; hysterectomy and salpingo-oophorectomy alone in 1 case, in 1 case followed by radiation, in 6 cases associated with pelvic node dissection, of which 2 cases were followed by radiotherapy; 2 cases were treated with hormonal therapy, 1 alone and 1 in association with surgery and radiation. In 2 cases [78], hormonal therapy was the choice and the patients were treated successfully with hormonal therapy, suggesting the presence of, at least, progesterone receptors. In our case, similarly to those reported by Ferrandina et al [12] and Mhawech et al [11], estrogen and progesterone receptors were negative.…”

Section: Discussionmentioning

confidence: 99%

“…Despite the fact that cervical GCC is known to be associated with poor prognosis; currently, the specific prognosis of EGCC remains unknown. Particularly, it is not possible to arrive at any conclusion considering the limited data available and the small sample size of the reported studies [678910111213].…”

Section: Discussionmentioning

confidence: 99%

“…Christopherson et al [6] described the first case of endometrial GCC (EGCC) in 1982. EGCC is a very rare occurrence, and to the best of our knowledge, only 14 cases have been reported till date [678910111213]. EGCC accounts for approximately 0.5% of all carcinomas in the endometrium [6] and is frequently considered as a variant of the adenosquamous endometrial carcinoma.…”

Section: Introductionmentioning

confidence: 99%

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A case of endometrial glassy cell carcinoma: a rare entity which necessitates of better understanding

et al. 2019

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Endometrial glassy cell carcinoma (EGCC) is a rare neoplasm, accounting for 0.5% of the carcinomas in the endometrium, composed of cells with granular eosinophilic or amphophilic cytoplasm, giving it a ground glass appearance. Till date, only 14 cases of this carcinoma have been reported. In this report, we have described a case of EGCC to help define standard diagnostic criteria and better understand the course, ideal treatment, and accurate prognosis of this disease. We report a case of a 64-year-old woman diagnosed with EGCC after an abnormal pap smear. She underwent a hysteroscopy, which led to the histological diagnosis. Laparotomic total hysterectomy and bilateral salpingo-oophorectomy were performed with pelvic lymphadenectomy and peritoneal and omental biopsies. Final pathological examination confirmed the initial diagnosis. Pelvic nodes removed during surgery and peritoneal and omental biopsies were negative for tumor cells. Treatment was considered appropriate and the patient did not require additional therapies. She was subsequently assigned to clinical follow-up and is alive, with no evidence of the disease.

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Glassy cell carcinoma of the endometrium responsive to megestrol acetate

Cited by 8 publications

References 5 publications

Primary adenosquamous carcinoma of the endometrium with glassy cell features. A diagnostic pitfall as a very rare tumour type in the endometrium

Primary adenosquamous carcinoma of the endometrium with glassy cell features. A diagnostic pitfall as a very rare tumour type in the endometrium

Glassy Cell Carcinoma of the Endometrium Presenting as an Intracavitary Leiomyoma on Ultrasound

A case of endometrial glassy cell carcinoma: a rare entity which necessitates of better understanding

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