Glassy cell carcinoma of the cervix: a literature review

Żółciak-Siwińska, Agnieszka; Jońska-Gmyrek, Joanna

doi:10.1016/j.ejogrb.2014.03.035

Cited by 23 publications

(37 citation statements)

References 38 publications

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“…Previous studies have found a strong association between cervical GCC and high-risk HPV infection [3, 7–12], which would be consistent with the findings in the present study. According to an accumulation of the present and previous data, the overall prevalence of high-risk HPV infection would be 51.3% (20/39; Table 2).…”

Section: Discussionsupporting

confidence: 94%

“…It has been documented that GCC does not have a distinctive cytological appearance [2, 3, 17]. In the present study, a pretreatment cytological diagnosis of GCC was made in only 1 case examined.…”

Section: Discussionmentioning

confidence: 64%

“…Glassy cell carcinoma (GCC) of the uterine cervix is a rare pathological form of cervical carcinoma that occurs in 1-2% of all cases [1–3]. The World Health Organization Classification currently considers this tumor to be a subtype of “other epithelial tumors” [4].…”

Section: Introductionmentioning

confidence: 99%

“…Two decades later, Littman et al [2] described GCC tumors in detail, redefining and amplifying the histological criteria. Since then, interest in GCC has expanded and a number of studies have been conducted [1–3, 7–22]. However, cervical GCC is not yet widely recognized.…”

Section: Introductionmentioning

confidence: 99%

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Cytomorphological characteristics of glassy cell carcinoma of the uterine cervix: histopathological correlation and human papillomavirus genotyping

2016

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A retrospective analysis was performed to describe the cytomorphological and histopathological findings and human papillomavirus (HPV) genotypes for glassy cell carcinoma (GCC) of the uterine cervix. Five cases of cervical GCC, in which the glassy cell features constituted at least 95% of the specimen, were included. Four patients had stage IIB GCCs and one had stage IIIB GCC. All patients underwent concurrent chemoradiation therapy. Based on pretreatment cytology, only 1 of the 5 cases was correctly diagnosed as GCC. The remaining cases were diagnosed as carcinoma of undetermined type, adenocarcinoma, poorly differentiated carcinoma, or unsatisfactory for evaluation. Cytological specimens had moderate cellularity and contained small clusters of tumor cells admixed with amphophilic, granular tumor diathesis. The tumor cells possessed large, round to oval nuclei and abundant, granular, ground-glass cytoplasm. The nuclei exhibited prominent eosinophilic nucleoli. The cytoplasm displayed sharp margins and molding, resulting in “intercellular windows” between neighboring attached cells. HPV genotyping revealed that high-risk HPV types 18, 16, and 31 were detected in 3, 1, and 1 cases, respectively. Consistent with this finding, all cases exhibited block p16 positivity, confirming the association of HPV infection with GCC. In conclusion, a distinct cytoplasmic margin, the characteristic histopathological feature of GCC, was observed in liquid-based cytological preparations. We suggest that sharp cytoplasmic outlines with molding and intercellular windows are characteristic cytomorphological features of GCC. Detection of high-risk HPV in all cases strongly supported the notion that high-risk HPV is involved in the pathogenesis of GCC.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cytomorphological characteristics of glassy cell carcinoma of the uterine cervix: histopathological correlation and human papillomavirus genotyping

2016

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“…Glassy cell carcinoma of the uterine cervix, accounting for approximately 1–2% of all cervical carcinomas, is a very rare form of cervical carcinoma [1–3]. According to the 2014 revised World Health Organization Classification of Tumours of Female Reproductive Organs, cervical glassy cell carcinoma is classified as a subtype of “other epithelial tumors” [4].…”

Section: Introductionmentioning

confidence: 99%

Clinical outcomes of advanced-stage glassy cell carcinoma of the uterine cervix: a need for reappraisal

Yoon

Kim

2016

Oncotarget

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We performed a retrospective analysis of the clinical features and patient outcomes for advanced-stage glassy cell carcinoma of the uterine cervix. The study was restricted to cases in which the glassy cell features constituted at least 95% of the biopsied specimen. During the study period, 675 patients were diagnosed with primary cervical carcinoma. Five (0.7%) of the 675 patients had cervical glassy cell carcinoma; of these, three were premenopausal, and two were postmenopausal. Abnormal vaginal bleeding was the most frequent presenting symptom. Glassy cell carcinoma presented as a fungating, exophytic, or infiltrative mass. The greatest tumor dimension ranged from 3 to 9 cm. All patients had parametrial extension. Four patients had stage IIB tumors, and one had a stage IIIB tumor. All patients received concurrent chemoradiation therapy. The patient with a stage IIIB tumor died of hypovolemic shock caused by upper gastrointestinal bleeding during radiation therapy. Three patients with stage IIB tumors survived for more than 8 years without tumor recurrence or metastasis. One of these three patients died of pelvic recurrence 10 years after the initial diagnosis. Cervical glassy cell carcinoma has traditionally been considered an aggressive, highly malignant tumor with poor prognosis, but our data suggest that patient survival is not significantly decreased compared with other histological types of cervical carcinoma. It will be necessary to analyze patient outcomes using a larger number of cervical glassy cell carcinoma cases to confirm our findings.

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Other Cervical Neoplasms

Chang

Colgan

2017

Pathology of the Cervix

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Glassy cell carcinoma of the cervix: a literature review

Cited by 23 publications

References 38 publications

Cytomorphological characteristics of glassy cell carcinoma of the uterine cervix: histopathological correlation and human papillomavirus genotyping

Cytomorphological characteristics of glassy cell carcinoma of the uterine cervix: histopathological correlation and human papillomavirus genotyping

Clinical outcomes of advanced-stage glassy cell carcinoma of the uterine cervix: a need for reappraisal

Other Cervical Neoplasms

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