Glassy cell carcinoma of the cervix

Littman, Philip; Clement, Philip B.; Henriksen, Birgit; Wang, C. C.; Robboy, Stanley J.; Taft, Priscilla D.; Ulfelder, Howard; Scully, Robert E.

doi:10.1002/1097-0142(197605)37:5<2238::aid-cncr2820370513>3.0.co;2-d

Cited by 111 publications

(74 citation statements)

References 6 publications

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“…Other poorly differentiated and possibly closely related cervical carcinomas have some but not all the characteristics of glassy cell carcinoma, and still other cervical carcinomas contain minor components of glassy cell carcinoma; tumors in both these groups should be excluded from the category of glassy cell carcinoma as originally defi ned. 5 Glassy cell carcinoma was found in the present patient by cervical cyto-screening performed during pregnancy. Glassy cell carcinoma generally affects younger women, as described above, and its association with pregnancy has been indicated.…”

Section: Discussionmentioning

confidence: 51%

“…4 The prognosis of patients with glassy cell carcinoma is considered to be poor because of its rapid progression, resistance to radiation therapy and chemotherapy, and metastatic/recurrent nature. 5 Histologically characterized by solid alveolar growth of tumor cells with abundant glassy cytoplasm, glassy cell carcinoma is a poorly differentiated cancer lacking glandular structures, plasmodesma, or keratinocytes. Intercellular boundaries are clear, and distinct nucleoli are present.…”

Section: Discussionmentioning

confidence: 99%

“…Scant stroma and numerous small round cells, as well as substantial eosinophilic infi ltration, have been described. 1,4,5,6 The differential diagnosis of glassy cell carcinoma from large-cell, nonkeratinizing squamous cell carcinoma or other poorly differentiated carcinoma is often diffi cult. 4 Histologic features that are often seen in nonkeratinizing squamous cell carcinoma, but very rarely seen in glassy cell carcinoma, include intercellular bridges, abundant intracellular glycogen, and squamous differentiation in the form of dyskeratotic cells.…”

Section: Discussionmentioning

confidence: 99%

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Glassy cell carcinoma of the uterine cervix responsive to neoadjuvant intraarterial chemotherapy

Nagai

Okubo²,

Sakaguchi³

et al. 2008

Int J Clin Oncol

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Described as a poorly differentiated adenosquamous cancer, glassy cell carcinoma of the uterine cervix is a rare disease considered to have an extremely poor prognosis. Saitama Medical Center has been offering neoadjuvant intraarterial chemotherapy (NAC) to cervical cancer patients as a means of avoiding postoperative radiation therapy, achieving downstaging, and improving prognosis. We report a patient with glassy cell carcinoma of the uterine cervix who responded to NAC, and we discuss this case with reference to reports in the literature. A 28-year-old gravida 1, para 0 patient was referred to the Department of Obstetrics and Gynecology at Saitama Medical Center for concurrent cervical cancer at 23.5 gestational weeks. The patient was admitted to our center following the diagnosis of stage IIb cervical cancer (glassy cell carcinoma), to await fetal development, and an elective cesarean section was performed at slightly more than 29 gestational weeks. Three cycles of NAC with carboplatin (CBDCA)/etoposide/epirubicin, started 3 days after the operation, shrank the tumor remarkably. An extended radical hysterectomy was subsequently performed. It has been 6 years, to date, since the initial treatment, and our patient is alive and disease/recurrence free.

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Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Glassy cell carcinoma of the uterine cervix responsive to neoadjuvant intraarterial chemotherapy

Nagai

Okubo²,

Sakaguchi³

et al. 2008

Int J Clin Oncol

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“…The World Health Organization Classification currently considers this tumor to be a subtype of “other epithelial tumors” [4]. The mean patient age of those with GCC is ~10 years less than that of patients with squamous cell carcinoma or adenocarcinoma of the cervix [1, 2, 5]. GCC was first described by Cherry and Glucksmann [6] in 1956 as a specific and distinctive entity of the most poorly differentiated adenosquamous carcinoma.…”

Section: Introductionmentioning

confidence: 99%

“…They defined the histological diagnostic criteria and indicated that this tumor was uncommon and associated with poor prognosis. Two decades later, Littman et al [2] described GCC tumors in detail, redefining and amplifying the histological criteria. Since then, interest in GCC has expanded and a number of studies have been conducted [1–3, 7–22].…”

Section: Introductionmentioning

confidence: 99%

Cytomorphological characteristics of glassy cell carcinoma of the uterine cervix: histopathological correlation and human papillomavirus genotyping

2016

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A retrospective analysis was performed to describe the cytomorphological and histopathological findings and human papillomavirus (HPV) genotypes for glassy cell carcinoma (GCC) of the uterine cervix. Five cases of cervical GCC, in which the glassy cell features constituted at least 95% of the specimen, were included. Four patients had stage IIB GCCs and one had stage IIIB GCC. All patients underwent concurrent chemoradiation therapy. Based on pretreatment cytology, only 1 of the 5 cases was correctly diagnosed as GCC. The remaining cases were diagnosed as carcinoma of undetermined type, adenocarcinoma, poorly differentiated carcinoma, or unsatisfactory for evaluation. Cytological specimens had moderate cellularity and contained small clusters of tumor cells admixed with amphophilic, granular tumor diathesis. The tumor cells possessed large, round to oval nuclei and abundant, granular, ground-glass cytoplasm. The nuclei exhibited prominent eosinophilic nucleoli. The cytoplasm displayed sharp margins and molding, resulting in “intercellular windows” between neighboring attached cells. HPV genotyping revealed that high-risk HPV types 18, 16, and 31 were detected in 3, 1, and 1 cases, respectively. Consistent with this finding, all cases exhibited block p16 positivity, confirming the association of HPV infection with GCC. In conclusion, a distinct cytoplasmic margin, the characteristic histopathological feature of GCC, was observed in liquid-based cytological preparations. We suggest that sharp cytoplasmic outlines with molding and intercellular windows are characteristic cytomorphological features of GCC. Detection of high-risk HPV in all cases strongly supported the notion that high-risk HPV is involved in the pathogenesis of GCC.

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Glassy cell carcinoma of the uterine cervix

Piura

Rabinovich

Meirovitz

et al. 1999

Journal of Surgical Oncology

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Background and Objectives Glassy cell carcinoma (GCC) of the uterine cervix is a rare and highly malignant tumor, accounting for only 1%–2% of all cervical carcinomas. The purpose of this study was to investigate the clinical findings, treatment, and outcome of patients with cervical GCC in the south of Israel. Methods Data from the files of 5 patients with cervical GCC who were managed at the Soroka Medical Center, Beer‐Sheva, Israel, between January 1961 and June 1999 were evaluated. Results Age at diagnosis ranged from 32 to 84 years, with 1 patient pregnant at the time of diagnosis. Vaginal bleeding was the prevailing presenting symptom. The cervical lesion was exophytic in 4 patients and endophytic (“barrel‐shaped”) in 1 patient. Mean tumor size was 3.9 cm. Three patients with stage IB1 disease had radical hysterectomy and bilateral pelvic lymph node dissection followed by either external pelvic radiotherapy or brachytherapy or both. All 3 patients were alive without disease 4, 12, and 18 months after initial diagnosis, respectively. One patient with stage IIIB disease had external pelvic radiotherapy alone and died of disease 12 months after initial diagnosis. One patient with stage IVB disease refused treatment and died of disease 3 months after initial diagnosis. Conclusions Cervical GCC is a rare variant of cervical cancer with distinct histologic features and an alleged aggressive clinical behavior. For early‐stage disease, the treatment of choice seems to be radical surgery followed by chemoradiotherapy. J. Surg. Oncol. 1999;72:206–210. © 1999 Wiley‐Liss, Inc.

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Glassy cell carcinoma of the cervix

Cited by 111 publications

References 6 publications

Glassy cell carcinoma of the uterine cervix responsive to neoadjuvant intraarterial chemotherapy

Glassy cell carcinoma of the uterine cervix responsive to neoadjuvant intraarterial chemotherapy

Cytomorphological characteristics of glassy cell carcinoma of the uterine cervix: histopathological correlation and human papillomavirus genotyping

Glassy cell carcinoma of the uterine cervix

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