Glandular odontogenic cyst: a case report

Abstract

The glandular odontogenic cyst (GOC) is a rare developmental lesion considered a distinct entity because of its uncommon histopathological characteristics. It has morphological similarities to other lesions, which makes its histopathological diagnosis challenging for some pathologists. This lesion can involve either jaws, but the anterior region of the mandible is the most affected area. It strikes distinct age groups, with an average patient age of 50 years. It can exhibit a tendency towards recurrence when conservative treatment is administered. It is believed that the low prevalence of GOC in the literature is because of not only its rarity, but principally to the fact that its main characteristics are also found in other pathological entities, thereby generating controversial diagnoses. The aim of the present article is to report a case of GOC in a 40‐year‐old female patient exhibiting an intrabone cyst in the anterior mandibular region. The initial diagnostic hypothesis by means of radiographic imaging was of a traumatic bone cyst. After histological analysis, the lesion was diagnosed as GOC. The specimen was stained with haematoxylin and eosin, and then with the Periodic Acid Schiff (PAS) method. Through immunohistochemical analysis, the cyst tested positively for the Ki‐67 and p53 antibodies as well as high molecular pan‐cytokeratin.

Glandular odontogenic cyst: a challenge in diagnosis and treatment

“…To date, a total of 111 cases of GOC have been reported in 48 articles in the English language literature, approximately half of these in the last 7 years (Padayachee and Van Wyk, 1987; Gardner et al , 1988; Ficarra et al , 1990; Lindh and Larsson, 1990; Patron et al , 1991; Sadeghi et al , 1991; Van Heerden et al , 1992; Gardner and Morency, 1993; De Carvalho et al , 1994; Semba et al , 1994; Takeda, 1994; Toida et al , 1994; Economopoulou and Patrikiou, 1995; Hussain et al , 1995; High et al , 1996; Ide et al , 1996; Savage et al , 1996; Baliga et al , 1997; Machade de Sousa et al , 1997; Magnusson et al , 1997; Manojlovic et al , 1997; Ramer et al , 1997; Koppang et al , 1998; Chavez and Richter, 1999; Damm and Fantasia, 2000; Jose et al , 2000; Lin et al , 2000; Tosios et al , 2000; Barreto et al , 2001; Bhatt et al , 2001; Babburi et al , 2003; Ertas et al , 2003; Geist et al , 2003; Manor et al , 2003; Ferreira et al , 2004; Pires et al , 2004; Tran et al , 2004; Abu‐Id et al , 2005; Demetriades et al , 2005; Kaplan et al , 2005a; Lo Muzio et al , 2005; Qin et al , 2005; Velez, 2006; Kasaboglu et al , 2006; Shen et al , 2006; Sittitavornwong et al , 2006).…”