Glandular lesions of the cervix—cytological and histological correlation

Jackson, Simona; Hollingworth, Tony; Anderson, Marion C.; Johnson, Joanna; Hammond, R. H.

doi:10.1046/j.1365-2303.1996.37382373.x

Cited by 19 publications

(20 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a study of Raab SS and co-workers [23] an interobserver variability of Papanicolaou smear diagnoses of atypical glandular cells of undetermined significance with a sensitivity of only 63% and a specificity of 58% is reported. Our tissue-proven follow-up findings are summarized in Table 4, and regroup the spectrum of potential pitfalls, that had also been reported by other groups [30,33-38]. So 31 of our AGC-cases were associated with tissue-proven endocervical squamous lesions, 28 corresponding to squamous intraepithelial lesions and 3 to invasive squamous carcinomas and benign lesions such as irritated endocervical and endometrial polyps or glandular hyperplasia.…”

Section: Discussionsupporting

confidence: 63%

See 1 more Smart Citation

Atypical glandular cells in conventional cervical smears: Incidence and follow-up

et al. 2004

View full text Add to dashboard Cite

BackgroundAtypical glandular cells on cervical smears are often associated with clinically significant uterine lesions. The frequency and accuracy of AGC-NOS (i.e. atypical glandular cells, not otherwise specified) diagnoses, regardless of the gland cell type or the degree of suspicion, and their outcome were investigated.MethodsFrom January 1, 1990 to December 31, 1999 a total of 261 patients had an AGC-NOS diagnosis made by conventional cervical Papanicolaou smear interpretation representing 0.05% of all Pap-smears analyzed at the national level. 191 (73.2%) patients had a subsequent histological examination, 8 samples were not representative by origin and were excluded.ResultsOut of 183 AGC-NOS diagnosed, 56.3% (103/183) were associated with tissue-proven precancerous and/or cancerous lesions, 44% being of endocervical and 56% of endometrial origin. 75% of all AGC-patients were asymptomatic. 66.7% (6/9) of the patients with subsequent invasive endocervical adenocarcinoma (AC) and 56% (28/50) of those patients with invasive endometrial AC were without clinical symptoms. 3 patients out of 9 with an invasive endocervical AC were 35 years of age or less. 10.1% and 12.3% of all 'new' tissue-proven invasive endocervical or endometrial AC respectively recorded by the national Morphologic Tumour Registry (MTR) were first identified by a cytological AGC-NOS diagnosis.ConclusionOur findings emphasize the importance of the cytological AGC-category even in the absence of a precise origin or cell type specification. 56% of the AGC-diagnoses being associated with significant cancerous or precancerous conditions, a complete and careful evaluation is required.

show abstract

Section: Discussionsupporting

confidence: 63%

“…All of there 15 endometrial AC were symptomatic. Jackson et al [30] reported a series of 34 asymptomatic cases giving a final outcome of cervical glandular neoplasia in 45% including just one case of invasive disease.…”

Section: Discussionmentioning

confidence: 99%

Atypical glandular cells in conventional cervical smears: Incidence and follow-up

et al. 2004

View full text Add to dashboard Cite

show abstract

“…The stroma between glands is minimal to absent, giving a cribriform pattern, and hence the worry that the lesion is malignant. Vacuolated and occasionally clear cells may be present, and hence the lesion may be confused with clear cell invasive adenocarcinoma (31) .…”

Section: Pathology Of Cervical Glandular Neoplasiamentioning

confidence: 99%

The pathology and management of endocervical glandular neoplasia

El‐Ghobashy¹,

Shaaban²,

Herod³

et al. 2005

Int J Gynecol Cancer

View full text Add to dashboard Cite

The incidence of cervical glandular intraepithelial neoplasia and adenocarcinoma is rising, and our limited knowledge about these lesions presents the gynecologist with a management dilemma. Recently, pathologists have paid increasing attention to the diagnosis and pathogenesis of adenocarcinoma of the cervix. Although there is no uniformity in the management of these lesions, nonradical surgery appears to give satisfactory results especially in young women who want to preserve their fertility. This review focuses on the issues surrounding the histologic diagnosis of endocervical glandular abnormalities, including their classification, and discusses the management of cervical preinvasive glandular disease, including follow-up after treatment.

show abstract

“…Cytology plays an important role in the diagnosis and follow-up of endocervical lesions since these cellular changes do not frequently have clinical diagnostic symptoms or characteristic colposcopic features. 3,8,15,28 Though better detection has led to an increase in the identification of AC and its precursors, endocervical lesions may still be overlooked: their cytologic criteria are not well known or completely reproducible. Moreover, benign cervical changes, such as Arias-Stella reaction, microglandular hyperplasia, tubal or endometrial metaplasia, cervical endometriosis and mesonephric remnants, may be potential pitfalls in the cytologic diagnosis of adenocarcinoma in situ (AIS) or even AC.…”

Section: Objective: To Determine Whether Evaluating Morphologic Featumentioning

confidence: 99%