Glandular Congenital Lymphadenoma

Abstract

Cutaneous lymphadenoma is known to occur over a broad age range, from 14 to 72 years of age. We report the unique clinical and histologic presentation of a cutaneous lymphadenoma from the suprapubic abdomen of a neonate which may represent a novel subtype, glandular congenital lymphadenoma. Cutaneous lymphadenoma is a rare tumor with a distinct histologic triad of epithelial nodules, dense fibrous stroma, and intense intranodular lymphocytic infiltrate. Typically, it is a slow growing, skin colored papule, nodule, or plaque, clinically resembling a basal cell carcinoma and often occurring in the head and neck region or lower extremities.

Cutaneous Lymphadenoma: A Case Report and Immunohistochemical Study

“…We describe a case of cutaneous lymphadenoma, which is known to be infiltrated with various types of lymphocytes [1]. In this report, we employed immunohistochemical staining to verify the tumor-composing lymphocytes, especially focusing on the profiles of the T cell subsets.…”

“…Cutaneous lymphadenoma is a rare neoplasm that arises mainly on the skin of the head and neck [1, 2, 3, 4, 5, 6, 7, 8]. The exact pathogenesis remains unknown and the histogenesis is uncertain.…”

“…Previously, several reports suggested that, in cutaneous lymphadenoma, cells within both the lobules and interstitial area consist of CD1a + Langerhans cells, CD30 + T or B cells, and CD3 + T cells [1, 4]. More detailed investigation has not been performed yet.…”

“…Cutaneous lymphadenoma is an uncommon epithelial neoplasm with a prominent lymphoid infiltrate in the epithelial islands [1]. Cutaneous lymphadenoma was first described in 1991 by Santa Cruz et al [2] and has been reported in the literature under various names (e.g.…”

“…benign lymphoepithelial tumor of the skin and adamantinoid trichoblastoma) [3, 4, 5, 6, 7]. Though several reports suggest that tumor-infiltrating lymphocytes (TILs) consist of CD1a + S100 + Langerhans cells and CD3 + T cells, no detailed phenotypical analysis of T cells has been demonstrated yet [1]. …”