Glandular and extraglandular expression of costimulatory molecules in patients with Sjogren's syndrome

Matsumura, Ryutaro; Umemiya, K; Goto, Tetsuhisa; Nakazawa, Takahiro; Kagami, M; Tomioka, Hisao; Tanabe, E; Sugiyama, Toshiro; Sueishi, Makoto

doi:10.1136/ard.60.5.473

Cited by 63 publications

(65 citation statements)

References 32 publications

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“…Interestingly, controversy also exists on the role of apoptosis in patients with Sjögren's syndrome. Although apoptosis has been proposed as an important mechanism in the effector phase of the disease (Kong et al, 1997(Kong et al, , 1998aManganelli et al, 1997;Matsumura et al, 1998), Fas-induced apoptosis was recently reported to be rare in minor salivary glands of patients with Sjögren's sydrome, despite expression of Fas and FasL (Ohlsson et al, 2001). Because fixation and pretreatment of the sections may influence the outcome of the TUNEL staining (Labat-Moleur et al, 1998;Negoescu et al, 1996), careful comparison with the control tissue is critical in the evalutation of TUNELstained sections.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, epithelial cells expressed high levels of the apoptosis receptor Fas and the deathinducing molecule Fas ligand (FasL). Infiltrating lymphocytes were shown to express FasL and bcl-2, enabling these cells to induce apoptosis, while themselves being protected from the induction of apoptotic cell death (Kong et al, 1997(Kong et al, , 1998aManganelli et al, 1997;Matsumura et al, 1998).…”

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confidence: 99%

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Apoptosis and Apoptosis-Related Molecules in the Submandibular Gland of the Nonobese Diabetic Mouse Model for Sjögren's Syndrome: Limited Role for Apoptosis in the Development of Sialoadenitis

Blokland

Helden-Meeuwsen

Wierenga‐Wolf

et al. 2003

Laboratory Investigation

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SUMMARY:Sjögren's syndrome is an autoimmune disease in which lymphocytic infiltrates develop in the exocrine glands.Pathogenetic aspects of the disease can be studied in the nonobese diabetic (NOD) mouse strain, a spontaneous model for Sjögren's syndrome. Apoptosis may play a role in the initation phase and in the effector phase of autoimmune diseases. Here, we have examined the role of apoptosis in the development of sialoadenitis in the NOD mouse. Apoptotic cells and the expression of apoptosis-related molecules were studied in submandibular glands (SMG) of NOD and NOD-scid mice before and after the onset of sialoadenitis. Numbers of apoptotic cells were not increased as compared with control mice, at any age. By immunohistochemistry, we demonstrated increased expression of Fas, Fas ligand (FasL), and bcl-2 on SMG epithelial cells of NOD and NOD-scid mice, as early as 3 days of age. mRNA expression of Fas and FasL was also examined in SMG by RQ-PCR. Low-level expression of Fas and FasL mRNA was observed in all mouse strains, from 1 day of age onward. We conclude that increased protein expression of Fas and FasL on SMG epithelial cells of NOD and NOD-scid mice probably indicates a genetically programmed abnormality in these cells that may form a trigger for the development of sialoadenitis in NOD mice. Because increased numbers of apoptotic cells were not observed, a role for actual apoptosis in the initiation or effector phase of sialoadenitis in the NOD mouse is unlikely. (Lab Invest 2003, 83:3-11).

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Apoptosis and Apoptosis-Related Molecules in the Submandibular Gland of the Nonobese Diabetic Mouse Model for Sjögren's Syndrome: Limited Role for Apoptosis in the Development of Sialoadenitis

Blokland

Helden-Meeuwsen

Wierenga‐Wolf

et al. 2003

Laboratory Investigation

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“…Several studies indicate the involvement of uncontrolled apoptosis in the pathogenesis of SS (27,28,45). Furthermore, enhanced apoptosis has been related to the impairment of secretory function and generation of autoantigens (17).…”

Section: Discussionmentioning

confidence: 99%

ALX/FPR2 receptor for RvD1 is expressed and functional in salivary glands

Nelson

Leigh

Mellas

et al. 2014

American Journal of Physiology-Cell Physiology

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“…Several studies have reported increased ductal epithelial cell turnover and consequent cell death (apoptosis) in the salivary glands of SS patients [36±40], although one study did not corroborate these observations [41]. The combination of a pro-inflammatory microenvironment and the increased exposure of`self-proteins' could lead to immunogenicity thereby explaining the presence in 70±80% of PSS patients of high titres of serum antibodies directed against the Ro (60kd and 52kd) and La (48kd) ribonucleoproteins [33] and other SS associated autoantibodies [34,35].…”

Section: Role Of Epithelial Cellsmentioning

confidence: 99%

Chemokines and Cell Trafficking in Sjögren's Syndrome

Amft

Bowman

2001

Scand J Immunol

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Sjögren's syndrome is a chronic inflammatory condition affecting exocrine glands, manifested clinically as dry eyes and dry mouth. It arises secondary to systemic immune‐mediated diseases such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), scleroderma or ‘primary’ Sjögren's syndrome. Histologically it is characterized by peri‐ductal aggregates of CD4 T lymphocytes, the frequent occurrence of ectopic germinal centres and, in some patients, B‐cell infiltration of ductal epithelium (myoepithelial sialadenitis). This latter lesion is the precursor for the development of low grade (MALT) B‐cell lymphoma. The identification over recent years of chemokines and their receptors enables us to address the specific processes involved in the migration of inflammatory cells into exocrine glands, the development of their secondary structures and patterns of retention within the glands and potentially the subsequent transformation of B cells into mucosa associated lymphoid tissue (MALT) lymphoma.

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Glandular and extraglandular expression of costimulatory molecules in patients with Sjogren's syndrome

Abstract: Objectives-To investigate the expression and regulation of CD80, CD86, and CD28 costimulatory molecules in sialoadenitis and interstitial nephritis in patients with Sjögren's syndrome (SS). Methods-Expression

Cited by 63 publications

References 32 publications

Apoptosis and Apoptosis-Related Molecules in the Submandibular Gland of the Nonobese Diabetic Mouse Model for Sjögren's Syndrome: Limited Role for Apoptosis in the Development of Sialoadenitis

Apoptosis and Apoptosis-Related Molecules in the Submandibular Gland of the Nonobese Diabetic Mouse Model for Sjögren's Syndrome: Limited Role for Apoptosis in the Development of Sialoadenitis

ALX/FPR2 receptor for RvD1 is expressed and functional in salivary glands

Chemokines and Cell Trafficking in Sjögren's Syndrome

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