Gland cell carcinoma (adenocarcinoma) of the uterine cervix

Abell, Murray R.; Gosling, John

doi:10.1016/0002-9378(62)90694-4

Cited by 97 publications

(26 citation statements)

References 27 publications

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“…The designation villoglandular papillary adenocarcinoma is rendered primarily on the basis of the appearance of the surface exophytic component of the tumor because when it invades the cervical wall, the papillary pattern typically is absent or inconspicuous and an elongated, branching glandular pattern predominates, a feature also noted by others. 27 The excellent prognosis in our series raises the consideration of a conservative surgical approach in young women with villoglandular papillary adenocarcinoma of the cervix with a view to preservation of reproductive function. One of our patients underwent only a cone biopsy.…”

Section: Vol 63mentioning

confidence: 99%

Villoglandular papillary adenocarcinoma of the uterine cervix. A clinicopathologic analysis of 13 cases

Young

Scully

1990

Cancer

129

108

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The clinical and pathologic features of 13 cervical papillary adenocarcinomas of villoglandular type were reviewed. They occurred in patients 23 to 54 years of age, with ten patients younger than 40 years of age. Microscopic examination revealed surface papillae that ranged from tall and thin to short and broad and contained central fibrous cores typically containing numerous inflammatory cells. The papillae were usually lined by stratified epithelial cells with slight to moderate nuclear atypicality and mitotic activity and no more than a minor degree of cellular budding. The deeper portions of the tumors were composed of branching tubular glands separated by a fibrous or fibromatous stroma and were more or less sharply demarcated from the adjacent cervical stroma. A hysterectomy was performed in 12 cases and only a cone biopsy in one case. The cone biopsy specimen and four of the hysterectomy specimens contained no residual carcinoma. In six uteri adenocarcinoma was confined to the inner third of the cervical wall whereas in two there was deep invasion. Follow-up of 2 to 14 years' duration including more than 5 years in ten cases has revealed no evidence of recurrent tumor. The excellent prognosis of the patients in this small series and the young age of many of them suggest that this tumor may be managed by a procedure less radical than a hysterectomy provided the tumor is superficial, has been completely excised, does not exhibit vascular space invasion, and close follow-up examination is possible.

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Section: Vol 63mentioning

confidence: 99%

Villoglandular papillary adenocarcinoma of the uterine cervix. A clinicopathologic analysis of 13 cases

Young

Scully

1990

Cancer

129

108

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“…Although most adenocarcinomas of the uterine cervix contain some amounts of intra‐ and extracellular mucus, neoplasms that form numerous mucous nodules and are histopathologically similar to colloid carcinoma of the stomach or large intestine are encountered in the cervix only very rarely, especially in its pure form 1,2 . Early histopathological descriptions of this variant of adenocarcinoma in the cervix were published in articles by Abell and Gosling, 4 Lewis, 3 and Hurt et al. 5 These latter two authors and Fu et al.…”

Section: Discussionmentioning

confidence: 99%

Colloid carcinoma of the intestinal type in the uterine cervix: Mucin immunohistochemistry

Shintaku

Kushima²,

Abiko

2010

Pathology International

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A case of colloid carcinoma (gelatinous carcinoma) of the intestinal type in the uterine cervix is reported along with the findings of an immunohistochemical study of intracytoplasmic mucus of the neoplastic cells. The patient was a 69-year-old woman with a circumferential uterine cervical tumor measuring about 4 cm. Histopathological examination of the hysterectomy specimen demonstrated typical features of colloid carcinoma. The tumor consisted of numerous mucous nodules, and low-columnar or cuboidal cells with intracytoplasmic mucus lined the margins of the mucous nodules or floated within them. The cytoplasm of neoplastic cells was immunoreactive for both cytokeratins 7 and 20, and the intracytoplasmic mucus was immunoreactive for MUC2 but negative for MUC5AC and MUC6. Nuclei of tumor cells were immunoreactive for CDX2. Colloid carcinoma is a very rare variant of mucus-producing adenocarcinoma of the uterine cervix and probably a heterogeneous group that consists of neoplasms of different histogeneses, that is, neoplasms of endocervical, gastric, and intestinal origins. Results of the immunohistochemical studies in the present case showed that neoplastic cells produced mucus of the large intestine type, thus verifying the presence of a distinct subtype of colloid carcinoma of the cervix that shows the intestinal phenotype.

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“…It is frequently associated with dysplasias or malignancies of the adjacent squamous epithelium and with the presence of atypical reserve cells. Patients with adenocarcinoma in situ are younger (mean age 39.1 years in thisseries) than the patients with invasive adenocarcinomas, which is most frequently diagnosed in the early part of the sixth decade (Abell & Gosling 1962, Rombaut et al 1966.…”

Section: Discussionmentioning

confidence: 99%

The morphogenesis of adenocarcinoma of the cervix—a complex pathological entity

Boon¹,

Kirk²,

Rietveld-Scheffers³

1981

Histopathology

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The cytological and histological features of 20 cases of adenocarcinoma of the cervix are presented of which 14 cases were in situ and two were microinvasive. The frequent association of atypia with malignancies of the cervical squamous epithelium is stressed. Abnormal reserve or stem cells were found in many of these cases. This study demonstrates the importance of the proper identification of these cells in cytological material and gives support to the theory that these cells play a role as a precursor cell to squamous and glandular neoplasms.

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Gland cell carcinoma (adenocarcinoma) of the uterine cervix

Cited by 97 publications

References 27 publications

Villoglandular papillary adenocarcinoma of the uterine cervix. A clinicopathologic analysis of 13 cases

Villoglandular papillary adenocarcinoma of the uterine cervix. A clinicopathologic analysis of 13 cases

Colloid carcinoma of the intestinal type in the uterine cervix: Mucin immunohistochemistry

The morphogenesis of adenocarcinoma of the cervix—a complex pathological entity

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