Glagov Remodeling of the Atherosclerotic Aorta Demonstrated by Cardiovascular Magnetic Resonance: The CORDA Asymptomatic Subject Plaque Assessment Research (CASPAR) Project

Abstract

Cardiovascular magnetic resonance detects subclinical aortic atherosclerosis, can follow plaque burden over time, and confirms the presence of Glagov remodeling with preservation of the lumen despite progression of plaque. Cardiovascular magnetic resonance is well suited for the longitudinal follow-up of the general population with atherosclerosis, may help in the understanding of the natural history of atherosclerosis, and in particular may help determine factors to retard disease progression at an early stage.

Atherosclerosis imaging as a benchmark in the development of novel cardiovasular drugs

“…Cardiovascular MRI noninvasively visualizes arterial walls in all dimensions [64][65][66][67][68] (Fig. 3), follows atherosclerosis progression over time, and detects the benefit of lipid-modifying drugs on atherosclerosis in relatively small sample sizes [69][70][71][72][73][74][75].…”

Métodos por imagem da aterosclerose em estudos de progressão/regressão: marcador substituto ou janela direta para o processo patológico da aterosclerose?

“…Studies with carotid MRI demonstrated an interstudy reproducibility of 4.4% 85 . A number of serial studies in humans have assessed CMR in the longitudinal measurement of aortic and carotid atheroma [86][87][88][89][90] .…”

The Use of Statins in Pediatrics: Knowledge Base, Limitations, and Future Directions

“…9 The risk of thrombotic events is most often related to qualitative properties of the atherosclerotic plaque itself that make it prone either to rupture and release the highly thrombogenic contents or to suffer an erosion of its intimal surface and potentially precipitate a clot. 3,10,11 Lastly, it has been appreciated that whereas the early atherosclerotic stages are reversible, the advanced stages are not. However, new data suggest that once established, advanced plaque can vary considerably in its inherent risk to precipitate an infarction, and it can evolve into a high-risk state or alternatively regress into a lower-risk one.…”