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Ng, Kee Peng; Saw, T.L.; Na, S.L.; Soo-Hoo, Tuck Soon

doi:10.1023/a:1007283211220

Cited by 28 publications

(7 citation statements)

References 17 publications

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“…Compatible with the study of Mohamed and Al-Ahmadey 49 and Sabatelli et al, 52 , most of the detected resistant strains belong to nonalbicans species (25%), emphasizing, its greatest potential to acquire resistance to fluconazole. Also, in accord with the finding of Ng et al, 23 who reported, amphotericin B and ketoconazole susceptibility data and showed that all yeast isolates were susceptible. The possibility of an increase in the percentage of the resistance to antifungal agents among Candida species might be due to widespread use of antifungal drugs, long-term use of suppressive azoles, and the use of short courses of antifungal drugs 23 .…”

Section: Discussionsupporting

confidence: 91%

Biofilm Formation and Antifungal Susceptibility of Candida Isolates From Oral Cavity After the Introduction of Fixed Orthodontic Appliances

et al. 2020

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Background and aims: Fixed Orthodontic Appliances (FOA) act as diverse impact zones and modify microbial adherence and colonization, acting as unfamiliar reserves and potential sources of infection This study was conducted to inspect the effect of the introduction of fixed orthodontic appliances on the growth and adherence (biofilm formation) of Candida species. And also to reveal the species distribution and antifungal sensitivity to isolated Candida species. Material and methods: The trial group was chosen from orthodontic patients whom were inspected clinically as soon as to get baseline information prior to active treatment. The group included 210 patients; 165 females, and 45 males, (mean age 21.6 ± 4.5 years). Clinical, demographic, and risk factor data were collected in a standard questionnaire and then each individual was directed to perform an oral rinse with phosphate-buffered saline, which was expectorated and processed proposed for the isolation and identification of Candida species by standard methods. After that, the isolated Candida species were tested for biofilm production by the phenotypic method i.e. Tissue culture palate methods (TCPM). Finally, antibiogram susceptibility pattern of oral Candida species was done by Kirby-Bauer disc diffusion method for amphotericin B, ketoconazole, and fluconazole. Results: The most common yeast colonized oral cavity after the introduction of FOA was C. albicans (72.5%), followed by C. glabrata and C. tropicalis (12.5%), while Candida parapsilosis only was 2.5%. The rate of formation of biofilms was 52.5% for all types of Candida, and it was found that biofilm formation occurs more frequently among C. tropicals and C. glabrata (60%) than C. albicans (48.3%). All Candida species isolates were sensitive to amphotericin B and ketoconazole while resistance to fluconazole was found in 40% of C. tropicalis and 20% in C. glabrata and 13.8% in C. albicans. Conclusion: The present study proved that C. albicans is still the major isolate from the oral cavity after the introduction of FOA, but non-albicans species colonization is raised and FOA might be a factor for biofilm formation. The C. tropicalis and C. glabrata were more– biofilm-producers compared to C. albicans. The isolated species in the current study are less susceptible to fluconazole and drug resistant factor in the Candida species isolates was found to be associated with biofilm formation. Peer Review History: Received 24 July 2020; Revised 13 August; Accepted 4 September, Available online 15 September 2020 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 6.5/10 Average Peer review marks at publication stage: 8.0/10 Reviewer(s) detail: Name: Dr. Wadhah Hassan Edrees Affiliation: Hajjah University, Yemen E-mail: edress2020@gmail.com Name: Dr. Muhammad Zahid Iqbal Affiliation: AIMST University, Kedah Darul Aman, Malaysia E-mail: drmmziqbal@gmail.com Comments of reviewer(s): Similar Articles: ORAL CANDIDA ALBICANS COLONIZATION RATE IN FIXED ORTHODONTICS PATIENTS ORAL C. ALBICANS COLONIZATION AND NON-CANDIDA ALBICANS CANDIDA COLONIZATION AMONG UNIVERSITY STUDENTS, YEMEN PREVALENCE AND ASSOCIATED FACTORS OF ORAL NON-CANDIDA ALBICANS CANDIDA CARRIAGE IN DENTURE WEARERS IN SANA'A CITY- YEMEN

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Section: Discussionsupporting

confidence: 91%

Biofilm Formation and Antifungal Susceptibility of Candida Isolates From Oral Cavity After the Introduction of Fixed Orthodontic Appliances

et al. 2020

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“…All resistant Candida species to fluconazole were biofilm producers. In a study conducted by Punithavathy, [47] biofilm forming cells showed increased resistance to fluconazole. A study conducted by Ramage et al [7] showed that biofilms from all C. albicans strains tested were intrinsically resistant to fluconazole.…”

Section: Discussionmentioning

confidence: 99%

Exoenzymes Activity and Biofilm Production in Candida Species Isolated from Various Clinical Specimens in Benha University Hospital, Egypt

Khater

2014

BMRJ

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This work was carried out in collaboration between both authors. Author ESK planned and designed the study, wrote the protocol, collected the samples, performed the practical laboratory activities, participated in the interpretation of the results and analysis, drafted and critically revised the manuscript. Author MHAN participated in planning and designing the study, sample collection, participated in the interpretation of the results. Both authors read and approved the final manuscript.

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“…During the past decade there has been an increasing trend of systemic and fatal infections with non albicans species such as Candida tropicalis , Candida glabrata, Candida parapsilosis , Candida lusitaniae and Candida lipolytica . Identification of these species is essential for effective therapy in view of the emergence of resistance to antifungal drugs in these species [14]. Candida parapsilosis is a major emerging human pathogen that has dramatically increased in significance and prevalence over the past two decades, and is now one of the leading causes of invasive candidal disease.…”

Section: Discussionmentioning

confidence: 99%