Gitelman′s syndrome with panhypopituitarism: Reno-endocrine interplay

Abstract

Gitelman's syndrome is an inherited tubulopathy affecting thiazide-sensitive sodium chloride cotransporter, which manifests with hypokalemic alkalosis, hypomagnesemia, and hypocalciuria. Recently few cases have been described having an association of Gitelman's syndrome with pituitary abnormalities on imaging, though with normal hormonal status. We describe the first case of an adult patient having Gitelman's syndrome and hypopituitarism with abnormal pituitary imaging. She presented to us with hypotension, hypokalemia, hypomagnesemia with alkalosis, hypothyroidism, hypocortisolism, and hypogonadism. She was treated with replacement of electrolytes and hormones, to which she showed an excellent response.

Novel Compound Heterozygous Mutations of the SLC12A3 Gene in Gitelman Syndrome with Growth Hormone Deficiency and Hypothyroidism

“…So, the relationship between C. 1456G>A on the SCL12A3 gene and thyroid function needs further analysis. Another report (12) showed an adult patient with GS complicated with clinical biochemical manifestations of GS and hypothyroidism. Because of the clinical symptoms of short stature in this case, it is suggested that the causes of short stature in this child may be GS, partial GHD, and thyroid insufficiency.…”